Results 1 to 10 of about 84,737 (109)

CNOT7 facilitates radiation resistance in colorectal cancer through TRIM21/XRCC6-mediated non-homologous end joining repair [PDF]

Cell Death and Disease
Radiotherapy is essential in the treatment of colorectal cancer (CRC), but the presence of drug resistance leads to poor prognosis for CRC patients. Identifying targets and mechanisms for regulating radiotherapy resistance has high clinical value.
Yien Li, Luying Cui, Shaoke Wang, Qunye Zhao, Fenqi Du, Songtao Du, Chenfeng Yu, Mingyu Xia, Shihui Zhao, Tian Luan, Yanlong Liu, Binbin Cui   +11 more
doaj   +3 more sources

Discovery of Drug-like Inhibitors of the Human Caf1/CNOT7 poly(A)-Selective Nuclease Using Compound Screening [PDF]

Biomolecules
The human Ccr4–Not complex is a central regulator of post-transcriptional gene regulation, impacting on translation and mRNA degradation. In mRNA degradation, Ccr4–Not participates in the shortening of the mRNA poly(A)-tail via two catalytic subunits ...
Ishwinder Kaur, Lubna Hashmi, Peter M. Fischer, Gerlof Sebastiaan Winkler   +3 more
doaj   +3 more sources

Discovery of Substituted 5-(2-Hydroxybenzoyl)-2-Pyridone Analogues as Inhibitors of the Human Caf1/CNOT7 Ribonuclease [PDF]

Molecules
The Caf1/CNOT7 nuclease is a catalytic component of the Ccr4-Not deadenylase complex, which is a key regulator of post-transcriptional gene regulation. In addition to providing catalytic activity, Caf1/CNOT7 and its paralogue Caf1/CNOT8 also contribute a
Ishwinder Kaur, Gopal P. Jadhav, Peter M. Fischer, Gerlof Sebastiaan Winkler   +3 more
doaj   +4 more sources

CNOT7 depletion reverses natural killer cell resistance by modulating the tumor immune microenvironment of hepatocellular carcinoma [PDF]

FEBS Open Bio, 2020
A major obstacle to effective cancer immunotherapy is the tumor immune microenvironment. Natural killer (NK) cell resistance has been suggested as a primary cause of poor prognosis in hepatocellular carcinoma (HCC), which seemingly correlates with CNOT7 ...
Chongren Ren, Xiaojing Ren, Dujuan Cao, Haichao Zhao, Zhensheng Zhai, Huiyu Li, Yanjun Li, Xifeng Fu, Jiefeng He, Haoliang Zhao   +9 more
doaj   +3 more sources

Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7. [PDF]

PLoS Genetics, 2016
Accumulating evidence supports the role of an aberrant transcriptome as a driver of metastatic potential. Deadenylation is a general regulatory node for post-transcriptional control by microRNAs and other determinants of RNA stability.
Farhoud Faraji, Ying Hu, Howard H Yang, Maxwell P Lee, G Sebastian Winkler, Markus Hafner, Kent W Hunter   +6 more
doaj   +5 more sources

MicroRNA-126-5p Inhibits the Migration of Breast Cancer Cells by Directly Targeting CNOT7 [PDF]

Technology in Cancer Research & Treatment, 2020
Background: To assess the effect of microRNA-126-5p (miR-126-5p) on the migration of the breast cancer MCF7 cell line. Methods: GSE143564 was downloaded from the Gene Expression Omnibus (GEO; http://www.ncbi.nlm.nih.gov/geo ) to identify the ...
Yuying Miao BD, Jiang Lu BD, Baozhen Fan BD, Lecan Sun MD   +3 more
doaj   +3 more sources

Dynamic Control of Dendritic mRNA Expression by CNOT7 Regulates Synaptic Efficacy and Higher Cognitive Function [PDF]

Cell Reports, 2017
Translation of mRNAs in dendrites mediates synaptic plasticity, the probable cellular basis of learning and memory. Coordination of translational inhibitory and stimulatory mechanisms, as well as dendritic transport of mRNA, is necessary to ensure proper
Rhonda L. McFleder, Fernanda Mansur, Joel D. Richter   +2 more
doaj   +4 more sources

The Legionella pneumophila effector PieF modulates mRNA stability through association with eukaryotic CCR4−NOT [PDF]

mSphere
The eukaryotic CCR4−NOT deadenylase complex is a highly conserved regulator of mRNA metabolism that influences the expression of the complete transcriptome, representing a prime target for a generalist bacterial pathogen.
Harley O'Connor Mount, Malene L. Urbanus, Francesco Zangari, Anne-Claude Gingras, Alexander W. Ensminger   +4 more
doaj   +2 more sources

CCR4-NOT Transcription Complex Subunit 7 (CNOT7) Protein and Leukocyte-Associated Immunoglobulin-like Receptor-1 in Breast Cancer Progression: Clinical Mechanistic Insights and In Silico Therapeutic Potential. [PDF]

Int J Mol Sci
Metastatic breast cancer (BC) spread underscores the need for novel prognostic biomarkers. This study investigated CCR4-NOT Transcription Complex Subunit 7 (CNOT7) and leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) in BC progression and natural killer (NK) cell resistance. In the current study, 90 female BC patients (46 non-metastatic, 44
Elanany MM, Mostafa D, Hady AA, Abd Allah MYY, Ahmed NS, Elghazawy NH, Sippl W, Yamamoto T, Hamdy NM.   +8 more
europepmc   +3 more sources

The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.

PLoS ONE, 2012
The human BTG/TOB protein family comprises six members (BTG1, BTG2/PC3/Tis21, BTG3/Ana, BTG4/PC3B, TOB1/Tob, and TOB2) that are characterised by a conserved BTG domain.
Rachel Doidge, Saloni Mittal, Akhmed Aslam, G Sebastiaan Winkler   +3 more
doaj   +3 more sources