Results 11 to 20 of about 84,756 (126)

CCR4‐NOT subunit CCF‐1/CNOT7 promotes transcriptional activation to multiple stress responses in Caenorhabditis elegans

Aging Cell, 2023
AbstractCCR4‐NOT is a versatile eukaryotic protein complex that controls multiple steps in gene expression regulation from synthesis to decay. In yeast, CCR4‐NOT has been implicated in stress response regulation, though this function in other organisms remains unclear. In a genome‐wide RNAi screen, we identified a subunit of the CCR4‐NOT complex, ccf‐1,
Hadi Tabarraei, Brandon M. Waddell, Kelly Raymond, Sydney M. Murray, Ying Wang, Keith P. Choe, Cheng‐Wei Wu   +6 more
openaire   +3 more sources

hCAF1/CNOT7 regulates interferon signalling by targeting STAT1 [PDF]

The EMBO Journal, 2013
Stringent regulation of the interferon (IFN) signalling pathway is essential for maintaining the immune response to pathogens and tumours. The transcription factor STAT1 is a crucial mediator of this response. Here, we show that hCAF1/CNOT7 regulates class I and II IFN pathways at different crucial steps.
Clément, Chapat, Chloé, Kolytcheff, Muriel, Le Romancer, Didier, Auboeuf, Pierre, De La Grange, Kamel, Chettab, Stéphanie, Sentis, Laura, Corbo   +7 more
openaire   +4 more sources

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity. [PDF]

FEBS Open Bio
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Soeda S, Montrose M, Takahashi A, Ishida R, Burriel S, Ohmine N, Natsume T, Adachi S, Kim M, Yamamoto T.   +9 more
europepmc   +2 more sources

DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity [PDF]

Nucleic Acids Research, 2019
Abstract The CCR4–NOT complex plays an important role in the translational repression and deadenylation of mRNAs. However, little is known about the specific roles of interacting factors. We demonstrate that the DEAD-box helicases eIF4A2 and DDX6 interact directly with the MA3 and MIF domains of CNOT1 and compete for binding. Furthermore,
Hedda A Meijer, Tobias Schmidt, Sarah L Gillen, Claudia Langlais, Rebekah Jukes-Jones, Cornelia H de Moor, Kelvin Cain, Ania Wilczynska, Martin Bushell   +8 more
openaire   +3 more sources

Alternative splicing of CNOT7 diversifies CCR4–NOT functions [PDF]

Nucleic Acids Research, 2017
The CCR4-associated factor CAF1, also called CNOT7, is a catalytic subunit of the CCR4-NOT complex, which has been implicated in all aspects of the mRNA life cycle, from mRNA synthesis in the nucleus to degradation in the cytoplasm. In human cells, alternative splicing of the CNOT7 gene yields a second CNOT7 transcript leading to the formation of a ...
Chapat, Clément, Chettab, Kamel, Simonet, Pierre, Wang, Peng, de La Grange, Pierre, Le Romancer, Muriel, Corbo, Laura   +6 more
openaire   +4 more sources

The CNOT4 Subunit of the CCR4‐NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis

Advanced Science, 2021
The CCR4‐NOT complex is a major mRNA deadenylase in eukaryotes, comprising the catalytic subunits CNOT6/6L and CNOT7/8, as well as CNOT4, a regulatory subunit with previously undetermined functions.
Xing‐Xing Dai, Yu Jiang, Jia‐Hui Gu, Zhi‐Yan Jiang, Yun‐Wen Wu, Chao Yu, Hao Yin, Jue Zhang, Qing‐Hua Shi, Li Shen, Qian‐Qian Sha, Heng‐Yu Fan   +11 more
doaj   +1 more source

Identification of Key Circulating Exosomal microRNAs in Gastric Cancer

Frontiers in Oncology, 2021
Exosomal miRNAs (EmiRs) can be used for prediction of gastric cancer (GC) development. Supposedly, both plasma and urinary microRNAs can also be potential biomarkers for screening, but the diagnostic values of EmiRs in blood and urine are not fully ...
Xiaoqing Qian, Xiaoqing Qian, Feng Xie, Huabing Wei, Daxiang Cui   +4 more
doaj   +1 more source

CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex

Journal of Molecular Biology, 2022
The CCR4-NOT deadenylase complex is a major post-transcriptional regulator of eukaryotic gene expression. CNOT7 and CNOT8 are both vertebrate homologs of the yeast CCR4-NOT catalytic subunit Caf1. They are highly similar and are sometimes considered redundant, but Cnot7 and Cnot8 knockout mice exhibit different phenotypes, implying distinct ...
Patrick N, Stoney, Akiko, Yanagiya, Saori, Nishijima, Tadashi, Yamamoto   +3 more
openaire   +2 more sources

Integrated Deadenylase Genetic Association Network and Transcriptome Analysis in Thoracic Carcinomas

Molecules, 2022
The poly(A) tail at the 3′ end of mRNAs determines their stability, translational efficiency, and fate. The shortening of the poly(A) tail, and its efficient removal, triggers the degradation of mRNAs, thus, regulating gene expression.
Athanasios Kyritsis, Eirini Papanastasi, Ioanna Kokkori, Panagiotis Maragozidis, Demetra S. M. Chatzileontiadou, Paschalina Pallaki, Maria Labrou, Sotirios G. Zarogiannis, George P. Chrousos, Dimitrios Vlachakis, Konstantinos I. Gourgoulianis, Nikolaos A. A. Balatsos   +11 more
doaj   +1 more source

CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development

Cell Reports, 2021
Summary: CCR4-NOT deadenylase is a major regulator of mRNA turnover. It contains two heterogeneous catalytic subunits CNOT7/8 and CNOT6/6L in vertebrates. The physiological function of each catalytic subunit is unclear due to the gene redundancy. In this
Xing-Xing Dai, Zhi-Yan Jiang, Yun-Wen Wu, Qian-Qian Sha, Yang Liu, Jia-Yi Ding, Wen-Dong Xi, Jing Li, Heng-Yu Fan   +8 more
doaj   +1 more source