Results 21 to 30 of about 84,756 (126)
Acta Neuropathologica Communications, 2021 Although abnormal accumulation of amyloid in the brain is an early biomarker of Alzheimer’s disease (AD), wide variation in cognitive trajectories during life can be seen in the setting of brain amyloidosis, ranging from maintenance of normal function to
Vijay K. Ramanan +13 more
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Advanced Science, Volume 10, Issue 26, September 15, 2023., 2023 The study analyzes transcriptomes, translatomes, and proteomes of mouse and human GV oocytes at the single‐cell level with a focus on conservations and differences in maternal aging between the two species. N6‐methyladenosine (m6A) reader YTHDF3 and alternative splicing factor SRSF6 are associated with the aging‐associated translational control in ...
Jiana Huang +13 more
wiley +1 more source
Cells, 2023 The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression.
Nafiseh Chalabi Hagkarim +6 more
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Epigenetic reprogramming during the maternal‐to‐zygotic transition
MedComm, Volume 4, Issue 4, August 2023., 2023 Graphical Abstract: The DNA methylation, histone modification, chromatin structure, and RNA modification are important epigenetic modifications that are reprogrammed during the maternal‐to‐zygote transition (MZT). Their reprogramming processes are regulated by multiple underlying molecular mechanisms that were discussed in the paper.
Yurong Chen +4 more
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2022 Synthetic mRNAs are rising rapidly as alternative therapeutic agents for delivery of proteins. However, the practical use of synthetic mRNAs has been restricted by their low cellular stability as well as poor protein production efficiency.
Cheuk Yin Li +8 more
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Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta [PDF]
Nature Genetics, 2004 Spermatogenesis is a complex process that involves cooperation of germ cells and testicular somatic cells. Various genetic disorders lead to impaired spermatogenesis, defective sperm function and male infertility. Here we show that Cnot7(-/-) males are sterile owing to oligo-astheno-teratozoospermia, suggesting that Cnot7, a CCR4-associated ...
Takahisa, Nakamura +14 more
openaire +2 more sources
APOBEC3G protects the genome of human cultured cells and mice from radiation‐induced damage
The FEBS Journal, Volume 290, Issue 7, Page 1822-1839, April 2023., 2023 A3G protects mice from IR‐induced damage and promotes accurate DNA double‐strand breaks repair in cultured cells. Transgenic mice expressing A3G successfully survived lethal irradiation, whereas wild‐type controls quickly succumbed to radiation syndrome.
Yelena Britan‐Rosich +11 more
wiley +1 more source
Silencing of CCR4-NOT complex subunits affects heart structure and function
Disease Models & Mechanisms, 2020 The identification of genetic variants that predispose individuals to cardiovascular disease and a better understanding of their targets would be highly advantageous.
Lisa Elmén +13 more
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Open Biology, 2023 Alpha-synuclein (SNCA) accumulation plays a central role in the pathogenesis of Parkinson's disease. Determining and interfering with the mechanisms that control SNCA expression is one approach to limiting disease progression.
Fedon-Giasin Kattan +4 more
doaj +1 more source
Clinical Genetics, Volume 103, Issue 2, Page 156-166, February 2023., 2023 Abstract CNOT2 haploinsufficiency underlies a rare neurodevelopmental disorder named Intellectual Developmental disorder with NAsal speech, Dysmorphic Facies, and variable Skeletal anomalies (IDNADFS, OMIM 618608). The condition clinically overlaps with chromosome 12q15 deletion syndrome, suggesting a major contribution of CNOT2 haploinsufficiency to ...
Marcello Niceta +21 more
wiley +1 more source