Results 31 to 40 of about 84,756 (126)
Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability [PDF]
RNA Biology, 2020 Shortening of mRNA poly(A) tails (deadenylation) to trigger their decay is mediated mainly by the CCR4-NOT deadenylase complex. While four catalytic subunits (CNOT6, 6L 7, and 8) have been identified in the mammalian CCR4-NOT complex, their individual biological roles are not fully understood.
Dina Mostafa +10 more
openaire +3 more sources
Chimeric RNA-binding protein-based killing switch targeting hepatocellular carcinoma cells
Molecular Therapy: Nucleic Acids, 2021 Cancer cell-specific killing switches are synthetic circuits developed as an intelligent weapon to specifically eliminate malignant cells. RNA-delivered synthetic circuits provide safer means to control oncolytic functions, in which proteolysis ...
Jiong Yang, Shigang Ding
doaj +1 more source
Development of 14‐gene signature prognostic model based on metastasis for colorectal cancer
Journal of Clinical Laboratory Analysis, Volume 37, Issue 1, January 2023., 2023 A 14‐gene signature prognostic model was constructed by analyzing genes specifically expressed in metastatic colorectal tumors. This model can be used to predict the survival rates of CRC patients. We also preliminarily examined the immunology‐based mechanisms controlling colorectal tumor metastasis.
Tong Li +11 more
wiley +1 more source
WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023 Genetic oscillators play crucial roles in development. The hairy/Enhancer of split gene family (Hes/her) undergo cell‐autonomous genetic oscillations to regulate the timing of vertebrate segmentation and neural cell proliferation and differentiation. mRNA stability and translation are tightly regulated to maintain oscillatory expression.
Monica C. Blatnik +2 more
wiley +1 more source
Chemistry – A European Journal, Volume 28, Issue 42, July 26, 2022., 2022 Oligonucleotide mRNA poly(A) tail analogs containing various nucleotide modifications were evaluated as binders for poly(A) binding protein (PABP) using a microscale thermophoresis‐based assay. Their susceptibility to specific degradation by CNOT7 deadenylase was also examined in order to identify best stabilizing modifications.
Olga Perzanowska +3 more
wiley +1 more source
Post-transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity
Cell Reports, 2015 Uncoupling protein 1 (Ucp1) contributes to thermogenesis, and its expression is regulated at the transcriptional level. Here, we show that Ucp1 expression is also regulated post-transcriptionally.
Akinori Takahashi +6 more
doaj +1 more source
The Ccr4–Not Deadenylase Subunits CNOT7 and CNOT8 Have Overlapping Roles and Modulate Cell Proliferation [PDF]
Molecular Biology of the Cell, 2009 Accurate gene expression requires the precise control of mRNA levels, which are determined by the relative rates of nuclear (pre-)mRNA synthesis and processing, and cytoplasmic mRNA turnover. A key step in mRNA degradation is the removal of the poly(A) tail, which involves several deadenylases including components of the Ccr4–Not complex.
Aslam, A. +4 more
openaire +3 more sources
Pervasive yet nonuniform contributions of Dcp2 and Cnot7 to maternal
Genes to Cells, 2017 mRNA degradation is a fundamental biological process that erases transcribed genetic information from cells. During maternal‐to‐zygotic transition of animal development, thousands of maternal mRNAs are degraded by multiple mechanisms including microRNAs and codon‐mediated decay. Enzymatic requirements for maternal mRNA clearance, however, are not fully
Yuichiro Mishima, Yukihide Tomari
openaire +2 more sources
Cnot7-Null Mice Exhibit High Bone Mass Phenotype and Modulation of BMP Actions
Journal of Bone and Mineral Research, 2007 Abstract Cnot7 is a recently identified regulator of spermatogenesis in adult mice. Because Cnot7 binds to Tob, a BMP inhibitor shown to be involved in bone metabolism, we examined whether Cnot7 is involved in bone mass regulation by using adult Cnot7 deficient mice. Cnot7−/− mice exhibited a high bone mass phenotype.
Kaoru, Washio-Oikawa +9 more
openaire +2 more sources
Methylation recognition protein YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) regulates the proliferation, migration and invasion of osteosarcoma by regulating m6A level of CCR4-NOT transcription complex subunit 7 (CNOT7) [PDF]
Bioengineered, 2022 N6-methyladenosine (m6A) is one of the most significant modifications in human mRNAs. Emerging evidence indicates that m6A participates in the initiation and development of malignant tumors. Nevertheless, the biological roles and mechanism of m6A in osteosarcoma (OS) remain unclear. The purpose of this study was to investigate the role and mechanism of
Wei, Kang +3 more
openaire +2 more sources