Results 41 to 50 of about 84,756 (126)

Abnormal sperm morphology caused by defects in Sertoli cells of Cnot7 knockout mice

Archives of Histology and Cytology, 2004
Cnot7 is a co-factor of transcription regulation, expressed in a variety of tissues including the lung, liver, thyroid gland, and testis. Our previous study (Nakamura et al., 2004) showed that deletion of the Cnot7 gene in mice caused almost no abnormal phenotypes except for male infertility, due to oligo-astheno-teratozoospermia.
Takehiko, Ogawa, Chizuru, Ito, Takahisa, Nakamura, Yoichi, Tamura, Tadashi, Yamamoto, Tetsuo, Noda, Yoshinobu, Kubota, Kiyotaka, Toshimori   +7 more
openaire   +3 more sources

CNOT7 regulates lipid deposition in nonalcoholic fatty liver disease

Biochemical and Biophysical Research Communications
In recent years, the incidence rate of nonalcoholic fatty liver disease (NAFLD) has ascended with the increasing number of metabolic diseases such as obesity and diabetes, which will bring great medical burden to society. At present, multiple scientific experiments have found that the CCR4-NOT complex can participate in regulating obesity and energy ...
Jiahui Li, Weiheng Wen, Jitong Li, Tiancai Liu, Jia Sun, Hong Chen   +5 more
openaire   +2 more sources

Oncogenic Gene CNOT7 Promotes Progression and Induces Poor Prognosis of Glioma

Molecular Biotechnology
Abstract Glioma is the most common malignant brain tumor in the central nervous system with the poor prognosis of patients. The CNOT7 (CCR4-NOT Transcription Complex Subunit 7) is an important functional subunit of CCR4-NOT protein complex that has not been reported in glioma. In this study, we aimed to explore the function of CNOT7 in glioma.
Feng Lu, Xiulong Jiang, Kun Lin, Pengfeng Zheng, Shizhong Wu, Guangming Zeng, De Wei   +6 more
openaire   +2 more sources

Ubiquitination‐Dependent LLGL2 Degradation Drives Colorectal Cancer Progression via THBS3 mRNA Stabilization

Advanced Science, Volume 12, Issue 39, October 20, 2025.
During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang, Tiantian Zhang, Huimin Li, Zidan Li, Shuangshuang Yin, Yiman Liu, Chunze Zhang, Yuling Qiu, Haiyang Yu   +8 more
wiley   +1 more source

Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex

Frontiers in Genetics, 2013
The shortening of the poly(A) tail of cytoplasmic mRNA (deadenylation) is a pivotal step in the regulation of gene expression in eukaryotic cells. Deadenylation impacts on both regulated mRNA decay as well as the rate of mRNA translation.
Gerlof Sebastiaan Winkler, Dario L Balacco   +1 more
doaj   +1 more source

Gestational Valproate Exposure Induces Tissue‐Specific Transcriptomic Changes in the Neonatal Brain and Choroid Plexus in a Rat Model of Epilepsy, GAERS

European Journal of Neuroscience, Volume 61, Issue 10, May 2025.
This study used a rat model of absence epilepsy, Genetic Absence Epilepsy Rat from Strasbourg (GAERS), to investigate the effects of gestational valproate exposure on early postnatal brain cortex and lateral choroid plexus transcriptomes. Results showed distinct differential gene expression patterns between the two tissues, with substantially more ...
Fiona Qiu, Yifan Huang, Katarzyna M. Dziegielewska, Mark D. Habgood, Norman R. Saunders   +4 more
wiley   +1 more source

Pathway Analysis Hints Towards Beneficial Effects of Long-Term Vibration on Human Chondrocytes

Cellular Physiology and Biochemistry, 2018
Background/Aims: Spaceflight negatively influences the function of cartilage tissue in vivo. In vitro human chondrocytes exhibit an altered gene expression of inflammation markers after a two-hour exposure to vibration.
Ronald Lützenberg, Kendrick Solano, Christoph Buken, Jayashree Sahana, Stefan Riwaldt, Sascha Kopp, Marcus Krüger, Herbert Schulz, Kathrin Saar, Norbert Huebner, Ruth Hemmersbach, Johann Bauer, Manfred Infanger, Daniela Grimm, Markus Wehland   +14 more
doaj   +1 more source

Multi‐omics revealed that DCP1A and SPDL1 determine embryogenesis defects in postovulatory ageing oocytes

Cell Proliferation, Volume 58, Issue 3, March 2025.
Construct postovulatory ageing protein map to deeply analyse the dynamic changes of postovulatory ageing proteins. DCP1A accumulation accelerates maternal mRNA decay in postovulatory‐aged oocytes. SPDL1 is crucial for maintaining spindle/chromosome structure and chromosome euploidy in PostOA oocytes.
Li Kong, Yutian Gong, Yongyong Wang, Mengjiao Yuan, Wenxiang Liu, Heyang Zhou, Xiangyue Meng, Xinru Guo, Yongbin Liu, Yang Zhou, Teng Zhang   +10 more
wiley   +1 more source

1‐Hydroxy‐xanthine derivatives inhibit the human Caf1 nuclease and Caf1‐containing nuclease complexes via Mg2+‐dependent binding

FEBS Open Bio, 2019
In eukaryotic cells, cytoplasmic mRNA is characterised by a 3′ poly(A) tail. The shortening and removal of poly(A) tails (deadenylation) by the Ccr4‐Not nuclease complex leads to reduced translational efficiency and RNA degradation.
Blessing Airhihen, Lorenzo Pavanello, Gopal P. Jadhav, Peter M. Fischer, Gerlof Sebastiaan Winkler   +4 more
doaj   +1 more source

Methyltransferase‐Like 3‐Mediated N6‐Methyladenosine Modification on RNAs: A Novel Perspective for the Pathogenesis and Treatment of Bone Diseases

Journal of Cellular and Molecular Medicine, Volume 29, Issue 5, March 2025.
ABSTRACT Osteoarthritis, osteoporosis, and osteosarcoma are prevalent osseous pathologies associated with the aberrant functionality of chondrocytes, osteoclasts, and osteoblasts, respectively. These conditions frequently exhibit therapeutic resistance and possess a high mortality risk, thus representing substantial health threats.
Dongqiong Xiao, Deshuang Zhang, Yi Qu, Xiaojuan Su   +3 more
wiley   +1 more source