Results 51 to 60 of about 84,756 (126)

Osteoarthritis Bone Marrow MSCs Retain Regenerative Competence and Chemokine Responsiveness for Drug‐Based In Situ Tissue Engineering

Stem Cells International, Volume 2025, Issue 1, 2025.
Background Mesenchymal stromal cells (MSCs) support tissue repair in osteoarthritis (OA), with migration to damaged tissue being a key strategy in in situ tissue engineering. Their regenerative potential depends on factors such as differentiation, level of senescence, and responsiveness to signaling molecules.
Julia Sonnleitner, Katja Gulich, Axel Pruss, Carsten Perka, Angelika Gursche, Daniel Kendoff, Michael Sittinger, Shabnam Hemmati-Sadeghi, Tilo Dehne, Yuriy Petrenko   +9 more
wiley   +1 more source

Alzheimer’s disease master regulators analysis: search for potential molecular targets and drug repositioning candidates

Alzheimer’s Research & Therapy, 2018
Background Alzheimer’s disease (AD) is a multifactorial and complex neuropathology that involves impairment of many intricate molecular mechanisms. Despite recent advances, AD pathophysiological characterization remains incomplete, which hampers the ...
D. M. Vargas, M. A. De Bastiani, E. R. Zimmer, F. Klamt   +3 more
doaj   +1 more source

Admixture mapping of cognitive function in diverse Hispanic and Latino adults: Results from the Hispanic Community Health Study/Study of Latinos

Alzheimer's &Dementia, Volume 20, Issue 9, Page 6070-6081, September 2024.
Abstract INTRODUCTION We conducted admixture mapping and fine‐mapping analyses to identify ancestry‐of‐origin loci influencing cognitive abilities. METHODS We estimated the association of local ancestry intervals across the genome with five neurocognitive measures in 7140 diverse Hispanic and Latino adults (mean age 55 years).
Rui Xia, Xueqiu Jian, Amanda L. Rodrigue, Jan Bressler, Eric Boerwinkle, Biqi Cui, Martha L. Daviglus, Charles DeCarli, Linda C. Gallo, David C. Glahn, Emma E. M. Knowles, Jee‐Young Moon, Thomas H. Mosley, Claudia L. Satizabal, Tamar Sofer, Wassim Tarraf, Fernando Testai, John Blangero, Sudha Seshadri, Hector M. González, Myriam Fornage   +20 more
wiley   +1 more source

Identification of genes associated with technological properties of cow milk using GWA analysis and gene ontology

Аграрная наука Евро-Северо-Востока
In recent years, there has been a significant development of technologies in the field of genetics and breeding of cattle, which opens new opportunities for increasing productivity and quality of dairy products.
M. V. Levchenko, G. G. Karlikova, G. K. Petryakova, I. A. Lashneva, A. A. Sermyagin   +4 more
doaj   +1 more source

Extracellular vesicle‐packaged lncRNA from cancer‐associated fibroblasts promotes immune evasion by downregulating HLA‐A in pancreatic cancer

Journal of Extracellular Vesicles, Volume 13, Issue 7, July 2024.
Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterised by immune evasion that contribute to poor prognosis. Cancer‐associated fibroblasts (CAFs) play a pivotal role in orchestrating the PDAC tumour microenvironment. We investigated the role of CAF‐derived extracellular vesicle (EV)‐packaged long non‐coding RNAs (lncRNAs) in immune evasion ...
Hanming Yao, Chengzhi Huang, Jinmao Zou, Weiling Liang, Yue Zhao, Kege Yang, Ziyi Zhong, Shurui Zhou, Jiajia Li, Yaqing Li, Lishu Xu, Kaihong Huang, Guoda Lian   +12 more
wiley   +1 more source

Combined Transcriptome and Proteome Analysis of Immortalized Human Keratinocytes Expressing Human Papillomavirus 16 (HPV16) Oncogenes Reveals Novel Key Factors and Networks in HPV-Induced Carcinogenesis

mSphere, 2019
Although the role of high-risk human papillomaviruses (hrHPVs) as etiological agents in cancer development has been intensively studied during the last decades, there is still the necessity of understanding the impact of the HPV E6 and E7 oncogenes on ...
Ruwen Yang, Jana Klimentová, Elke Göckel-Krzikalla, Regina Ly, Nadine Gmelin, Agnes Hotz-Wagenblatt, Helena Řehulková, Jiří Stulík, Frank Rösl, Martina Niebler   +9 more
doaj   +1 more source

Targeting RNA modifications with pharmacological agents: New frontiers in cancer therapy

Cancer Medicine, Volume 13, Issue 7, April 2024.
The m6A methylation is catalysed by the writer complex and the demethylation is catalysed by the erasers. Different readers proteins determine the fate of m6A modification. These proteins have increasingly been recognised as targets for cancer therapy.
Angel Guan, Justin J.‐L. Wong
wiley   +1 more source

The Alzheimer's Disease Neuroimaging Initiative in the era of Alzheimer's disease treatment: A review of ADNI studies from 2021 to 2022

Alzheimer's &Dementia, Volume 20, Issue 1, Page 652-694, January 2024.
Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) aims to improve Alzheimer's disease (AD) clinical trials. Since 2006, ADNI has shared clinical, neuroimaging, and cognitive data, and biofluid samples. We used conventional search methods to identify 1459 publications from 2021 to 2022 using ADNI data/samples and reviewed 291 impactful ...
Dallas P. Veitch, Michael W. Weiner, Melanie Miller, Paul S. Aisen, Miriam A. Ashford, Laurel A. Beckett, Robert C. Green, Danielle Harvey, Clifford R. Jack Jr., William Jagust, Susan M. Landau, John C. Morris, Kwangsik T. Nho, Rachel Nosheny, Ozioma Okonkwo, Richard J. Perrin, Ronald C. Petersen, Monica Rivera Mindt, Andrew Saykin, Leslie M. Shaw, Arthur W. Toga, Duygu Tosun, for the Alzheimer's Disease Neuroimaging Initiative   +22 more
wiley   +1 more source

Roles of the CCR4‐Not complex in translation and dynamics of co‐translation events

WIREs RNA, Volume 15, Issue 1, January/February 2024.
Not5 ribosome binding ensures co‐translational organellar targeting and protein assembly. Prolonged ribosome pausing leading to post‐translocation ribosomes with empty A and E sites allows Not5 ribosome binding. This Not5 ribosome binding is key for co‐translational events such as organellar targeting or assembly of proteins.
Martine A. Collart, Léna Audebert, Martin Bushell   +2 more
wiley   +1 more source

Maternal mRNA deadenylation is defective in in vitro matured mouse and human oocytes

Nature Communications
Oocyte in vitro maturation is a technique in assisted reproductive technology. Thousands of genes show abnormally high expression in in vitro maturated metaphase II (MII) oocytes compared to those matured in vivo in bovines, mice, and humans.
Yusheng Liu, Wenrong Tao, Shuang Wu, Yiwei Zhang, Hu Nie, Zhenzhen Hou, Jingye Zhang, Zhen Yang, Zi-Jiang Chen, Jiaqiang Wang, Falong Lu, Keliang Wu   +11 more
doaj   +1 more source