Results 11 to 20 of about 529 (83)

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity. [PDF]

FEBS Open Bio
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Soeda S, Montrose M, Takahashi A, Ishida R, Burriel S, Ohmine N, Natsume T, Adachi S, Kim M, Yamamoto T.   +9 more
europepmc   +2 more sources

The CCR4–NOT complex suppresses untimely translational activation of maternal mRNAs

Development (Cambridge), 2023
Shou Soeda, Hiroko Kozuka-Hata, Tadashi Yamamoto   +2 more
exaly   +2 more sources

Differential gene expression of blood-based ABCA9, CNOT8, SESN1, UCP3, MAP2K1 and DDIT4 in Alzheimer’s disease

Neuroscience Research Notes, 2023
This study uncovered differential gene expression in blood to distinguish subjects with probable Alzheimer’s disease (AD) from normal elderly participants (non-demented controls, NDC). The participants were recruited via training (Phase 1) and validation cohorts (Phase 2).
Ainon Zahariah Samsudin, Kalavathy Ramasamy, Siong Meng Lim, Ai Vyrn Chin, Maw Pin Tan, Shahrul Bahyah Kamaruzzaman, Baharudin Ibrahim, Abu Bakar Abdul Majeed   +7 more
openaire   +1 more source

Multi‐Omics Analysis Reveals Translational Landscapes and Regulations in Mouse and Human Oocyte Aging

Advanced Science, Volume 10, Issue 26, September 15, 2023., 2023
The study analyzes transcriptomes, translatomes, and proteomes of mouse and human GV oocytes at the single‐cell level with a focus on conservations and differences in maternal aging between the two species. N6‐methyladenosine (m6A) reader YTHDF3 and alternative splicing factor SRSF6 are associated with the aging‐associated translational control in ...
Jiana Huang, Peigen Chen, Lei Jia, Tingting Li, Xing Yang, Qiqi Liang, Yanyan Zeng, Jiawen Liu, Taibao Wu, Wenqi Hu, Kehkooi Kee, Haitao Zeng, Xiaoyan Liang, Chuanchuan Zhou   +13 more
wiley   +1 more source

Delineation of the clinical profile of CNOT2 haploinsufficiency and overview of the IDNADFS phenotype

Clinical Genetics, Volume 103, Issue 2, Page 156-166, February 2023., 2023
Abstract CNOT2 haploinsufficiency underlies a rare neurodevelopmental disorder named Intellectual Developmental disorder with NAsal speech, Dysmorphic Facies, and variable Skeletal anomalies (IDNADFS, OMIM 618608). The condition clinically overlaps with chromosome 12q15 deletion syndrome, suggesting a major contribution of CNOT2 haploinsufficiency to ...
Marcello Niceta, Simone Pizzi, Francesca Inzana, Angela Peron, Somayeh Bakhtiari, Mathilde Nizon, Jonathan Levy, Cecilia Mancini, Benjamin Cogné, Francesca Clementina Radio, Emanuele Agolini, Dario Cocciadiferro, Antonio Novelli, Mustafa A. Salih, Maria Paola Recalcati, Rosangela Arancio, Marianne Besnard, Anne‐Claude Tabet, Michael C. Kruer, Manuela Priolo, Bruno Dallapiccola, Marco Tartaglia   +21 more
wiley   +1 more source

The CNOT4 Subunit of the CCR4‐NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis

Advanced Science, Volume 8, Issue 10, May 19, 2021., 2021
In the CCR4‐NOT complex, CNOT4 facilitates CNOT7‐mediated deadenylation/degradation of mRNAs from the zygotene to pachytene stage of spermatogenesis through its RNA recognition motif. CNOT4‐dependent mRNA removal in meiotic prophase is required for the appropriate expression of genes involved in the subsequent events of spermatogenesis, DSB repair ...
Xing‐Xing Dai, Yu Jiang, Jia‐Hui Gu, Zhi‐Yan Jiang, Yun‐Wen Wu, Chao Yu, Hao Yin, Jue Zhang, Qing‐Hua Shi, Li Shen, Qian‐Qian Sha, Heng‐Yu Fan   +11 more
wiley   +1 more source

Copy number variations contribute to malignant tumor development in children with serious birth defects. [PDF]

Mol Oncol
Children with birth defects are more likely to develop cancer. We observed strong heterogeneity and uneven distributions of copy number variations (CNVs) in 454 such children, with limited occurrence of cancer predisposition genes. However, consistency of the functional impact of CNVs on pathways, and enrichment of non‐coding RNA, was observed, showing
Liu Y, Glessner J, Qu HQ, Chang X, Qiu H, Wang T, Mentch FD, Hakonarson H.   +7 more
europepmc   +2 more sources

Nonsense‐mediated decay factor SMG7 sensitizes cells to TNFα‐induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1

Molecular Oncology, Volume 14, Issue 10, Page 2420-2435, October 2020., 2020
Yang et al. found that mutation of the nonsense‐mediated decay factor SMG7 enhanced resistance to tumor necrosis factor (TNF)‐induced apoptosis via two oncogenic pathways. Downregulation of CYLD and overexpression of the long noncoding RNA Pvt1 converge to promote NF‐κB activation.
Limeng Yang, Vanessa A. N. Kraft, Susanne Pfeiffer, Juliane Merl‐Pham, Xuanwen Bao, Yu An, Stefanie M. Hauck, Joel A. Schick   +7 more
wiley   +1 more source

Integrated Analysis of a Gene Correlation Network Identifies Critical Regulation of Fibrosis by lncRNAs and TFs in Idiopathic Pulmonary Fibrosis

BioMed Research International, Volume 2020, Issue 1, 2020., 2020
Idiopathic pulmonary fibrosis (IPF), the most frequent form of irreversible interstitial pneumonia with unknown etiology, is characterized by massive remodeling of lung architecture and followed by progressive loss of lung function. However, the key regulatory genes and the specific signaling pathways involved in the onset and progression of IPF still ...
Fan Wang, Pei Li, Feng-sen Li, Brandi L. Cantarel   +3 more
wiley   +1 more source

Interaction of NANOS2 and NANOS3 with different components of the CNOT complex may contribute to the functional differences in mouse male germ cells

Biology Open, 2014
NANOS2 and NANOS3 belong to the Nanos family of proteins that contain a conserved zinc finger domain, which consists of two consecutive CCHC-type zinc finger motifs, and contribute to germ cell development in mice.
Atsushi Suzuki, Yuki Niimi, Yumiko Saga
doaj   +1 more source