Results 11 to 20 of about 948 (123)

Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex

Frontiers in Genetics, 2013
The shortening of the poly(A) tail of cytoplasmic mRNA (deadenylation) is a pivotal step in the regulation of gene expression in eukaryotic cells. Deadenylation impacts on both regulated mRNA decay as well as the rate of mRNA translation.
Dario L Balacco, Sebastiaan Winkler
exaly   +3 more sources

Copy number variations contribute to malignant tumor development in children with serious birth defects. [PDF]

Mol Oncol
Children with birth defects are more likely to develop cancer. We observed strong heterogeneity and uneven distributions of copy number variations (CNVs) in 454 such children, with limited occurrence of cancer predisposition genes. However, consistency of the functional impact of CNVs on pathways, and enrichment of non‐coding RNA, was observed, showing
Liu Y, Glessner J, Qu HQ, Chang X, Qiu H, Wang T, Mentch FD, Hakonarson H.   +7 more
europepmc   +2 more sources

Mutation of Brain Aromatase Impairs Behavior and Neuroplasticity in Adult Zebrafish. [PDF]

J Neurochem
This study investigates the functional role of brain aromatase, encoded by the cyp19a1b gene, in zebrafish neurodevelopment and adult behavior. Using TALENs technology, we introduced a 10‐nucleotide deletion in exon 2, generating a zebrafish line that expresses a truncated aromatase protein.
Malleret C, Blanc-Legendre M, Guillot L, Lautrette-Quinveros H, Pavlidi P, Dalla C, Kokras N, Brion F, Toupin M, Chalmel F, Cousin X, Charlier TD, Pellegrini E.   +12 more
europepmc   +2 more sources

The CCR4–NOT complex suppresses untimely translational activation of maternal mRNAs

Development (Cambridge), 2023
Shou Soeda, Masaaki Oyama, Hiroko Kozuka-Hata   +2 more
exaly   +2 more sources

Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability. [PDF]

RNA Biol, 2020
Shortening of mRNA poly(A) tails (deadenylation) to trigger their decay is mediated mainly by the CCR4-NOT deadenylase complex. While four catalytic subunits (CNOT6, 6L 7, and 8) have been identified in the mammalian CCR4-NOT complex, their individual ...
Mostafa D, Takahashi A, Yanagiya A, Yamaguchi T, Abe T, Kureha T, Kuba K, Kanegae Y, Furuta Y, Yamamoto T, Suzuki T.   +10 more
europepmc   +3 more sources

CNOT1 regulates circadian behaviour through Per2 mRNA decay in a deadenylation-dependent manner. [PDF]

RNA Biol, 2022
Circadian clocks are an endogenous internal timekeeping mechanism that drives the rhythmic expression of genes, controlling the 24 h oscillatory pattern in behaviour and physiology.
Mohamed HMA, Takahashi A, Nishijima S, Adachi S, Murai I, Okamura H, Yamamoto T.   +6 more
europepmc   +3 more sources

The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7)/Caf1b (CNOT8) deadenylase enzymes [PDF]

The human BTG/TOB protein family comprises six members (BTG1, BTG2/PC3/Tis21, BTG3/Ana, BTG4/PC3B, TOB1/Tob, and TOB2) that display anti-proliferative activity in a number of cell types. They are characterised by a conserved N-terminal BTG domain that mediates interactions with the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylases.
Doidge, Rachel L.
openaire   +2 more sources

Multi‐Omics Analysis Reveals Translational Landscapes and Regulations in Mouse and Human Oocyte Aging

Advanced Science, Volume 10, Issue 26, September 15, 2023., 2023
The study analyzes transcriptomes, translatomes, and proteomes of mouse and human GV oocytes at the single‐cell level with a focus on conservations and differences in maternal aging between the two species. N6‐methyladenosine (m6A) reader YTHDF3 and alternative splicing factor SRSF6 are associated with the aging‐associated translational control in ...
Jiana Huang, Peigen Chen, Lei Jia, Tingting Li, Xing Yang, Qiqi Liang, Yanyan Zeng, Jiawen Liu, Taibao Wu, Wenqi Hu, Kehkooi Kee, Haitao Zeng, Xiaoyan Liang, Chuanchuan Zhou   +13 more
wiley   +1 more source

Delineation of the clinical profile of CNOT2 haploinsufficiency and overview of the IDNADFS phenotype

Clinical Genetics, Volume 103, Issue 2, Page 156-166, February 2023., 2023
Abstract CNOT2 haploinsufficiency underlies a rare neurodevelopmental disorder named Intellectual Developmental disorder with NAsal speech, Dysmorphic Facies, and variable Skeletal anomalies (IDNADFS, OMIM 618608). The condition clinically overlaps with chromosome 12q15 deletion syndrome, suggesting a major contribution of CNOT2 haploinsufficiency to ...
Marcello Niceta, Simone Pizzi, Francesca Inzana, Angela Peron, Somayeh Bakhtiari, Mathilde Nizon, Jonathan Levy, Cecilia Mancini, Benjamin Cogné, Francesca Clementina Radio, Emanuele Agolini, Dario Cocciadiferro, Antonio Novelli, Mustafa A. Salih, Maria Paola Recalcati, Rosangela Arancio, Marianne Besnard, Anne‐Claude Tabet, Michael C. Kruer, Manuela Priolo, Bruno Dallapiccola, Marco Tartaglia   +21 more
wiley   +1 more source

The CNOT4 Subunit of the CCR4‐NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis

Advanced Science, Volume 8, Issue 10, May 19, 2021., 2021
In the CCR4‐NOT complex, CNOT4 facilitates CNOT7‐mediated deadenylation/degradation of mRNAs from the zygotene to pachytene stage of spermatogenesis through its RNA recognition motif. CNOT4‐dependent mRNA removal in meiotic prophase is required for the appropriate expression of genes involved in the subsequent events of spermatogenesis, DSB repair ...
Xing‐Xing Dai, Yu Jiang, Jia‐Hui Gu, Zhi‐Yan Jiang, Yun‐Wen Wu, Chao Yu, Hao Yin, Jue Zhang, Qing‐Hua Shi, Li Shen, Qian‐Qian Sha, Heng‐Yu Fan   +11 more
wiley   +1 more source