CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex
CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT ComplexThe CCR4-NOT deadenylase complex is a major post-transcriptional regulator of eukaryotic gene expression. CNOT7 and CNOT8 are both vertebrate homologs of the yeast CCR4-NOT catalytic subunit Caf1. They are highly similar and are sometimes considered redundant, but Cnot7 and Cnot8 knockout mice exhibit different phenotypes, implying distinct ...
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