Results 31 to 40 of about 572 (99)

Cytotoxicity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine

Evidence-Based Complementary and Alternative Medicine, Volume 2013, Issue 1, 2013., 2013
Aim. The present study was designed to investigate the cytotoxicity of a panel of 280 Korean medicinal plants belonging to 73 families and 198 species against human CCRF‐CEM leukemia cells. Selected phytochemicals were investigated in more detail for their mode of action. Methods.
Victor Kuete, Ean-Jeong Seo, Benjamin Krusche, Mira Oswald, Benjamin Wiench, Sven Schröder, Henry Johannes Greten, Ik-Soo Lee, Thomas Efferth, Sookyung Lee   +9 more
wiley   +1 more source

MEK1 is associated with carboplatin resistance and is a prognostic biomarker in epithelial ovarian cancer [PDF]

, 2014
BACKGROUND: Primary systemic treatment for ovarian cancer is surgery, followed by platinum based chemotherapy. Platinum resistant cancers progress/recur in approximately 25% of cases within six months. We aimed to identify clinically useful biomarkers of
Győrffy, Balázs, Denkert C, Zsófia Pénzváltó, Carsten Denkert, Imre Pete, Lánczky, András, Nóra Meggyesházi, Norbert Szoboszlai, Krenács, Tibor, Lénárt J, Denke, Carsten, Tibor Krenács, Balázs Győrffy, Pénzváltó, Zsófia, Szoboszlai, Norbert, Julianna Lénárt, András Lánczky, Pete, Imre, Meggyesházi, Nóra, Lánczky A, Lénárt, Julianna   +20 more
core   +2 more sources

Ubiquitination‐Dependent LLGL2 Degradation Drives Colorectal Cancer Progression via THBS3 mRNA Stabilization

Advanced Science, Volume 12, Issue 39, October 20, 2025.
During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang, Tiantian Zhang, Huimin Li, Zidan Li, Shuangshuang Yin, Yiman Liu, Chunze Zhang, Yuling Qiu, Haiyang Yu   +8 more
wiley   +1 more source

Mutation of Brain Aromatase Impairs Behavior and Neuroplasticity in Adult Zebrafish

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
This study investigates the functional role of brain aromatase, encoded by the cyp19a1b gene, in zebrafish neurodevelopment and adult behavior. Using TALENs technology, we introduced a 10‐nucleotide deletion in exon 2, generating a zebrafish line that expresses a truncated aromatase protein.
Cassandra Malleret, Mélanie Blanc‐Legendre, Laëtitia Guillot, Harmony Lautrette‐Quinveros, Pavlina Pavlidi, Christina Dalla, Nikos Kokras, François Brion, Maryne Toupin, Frédéric Chalmel, Xavier Cousin, Thierry Dominique Charlier, Elisabeth Pellegrini   +12 more
wiley   +1 more source

fgf3/lia FGF signaling mediates the increase in caudal hypothalamic DC7 DA neurons in cnot8^m1061 mutant embryos.

, 2014
(A–F) Analysis of DA neurons in cnot8m1061 mutant embryos combined with a mutation in the fgf3 locus (liat24152) or pharmacological suppression of FGF signaling by SU5402.
Heiko B. Löhr (670637), Peter Koch (670636), Wolfgang Driever (55089)   +2 more
core   +1 more source

ZNHIT3 Regulates Translation to Ensure Cell Lineage Differentiation in Mouse Preimplantation Development

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Box C/D snoRNP complex regulates protein translation. This study identifies ZNHIT3 as a key component of the complex and ensures normal protein expression, including transcription factors orchestrating cell fate commitment, during early mouse embryogenesis.
Guanghui Yang, Qiliang Xin, Jurrien Dean
wiley   +1 more source

erm and pea3 expression in cnot8^m1061 mutants and WT siblings.

, 2014
(A, B) erm expression in WT siblings and cnot8m1061 mutants at 3 dpf. (C–H) pea3 expression in WT siblings and cnot8m1061 mutants at (C, D) 3 dpf and (E–H) 2 dpf.
Heiko B. Löhr (670637), Peter Koch (670636), Wolfgang Driever (55089)   +2 more
core   +1 more source

The cnot8^m1061 mutation affects FGF receptor expression levels.

, 2014
The expression of the four zebrafish FGF receptor genes fgfr1, 2, 3 and 4 was analyzed by WISH in cnot8m1061 mutants and WT siblings at 1, 2 and 3 dpf. All pictures show lateral views. Embryos were genotyped by PCR. Scale bar 100 µm in A for A–X.
Heiko B. Löhr (670637), Peter Koch (670636), Wolfgang Driever (55089)   +2 more
core   +1 more source

oxtl, tphd2 and crh gene expression in cnot8^m1061 embryos at 3 dpf.

, 2014
(A, B) oxtl, (C, D) tphd2 and (E–H) crh WISH expression analysis in wild-type siblings and cnot8m1061 mutants. (A–F) lateral views. (G, H) dorsal views. Boxes indicate areas of cell counts.
Heiko B. Löhr (670637), Peter Koch (670636), Wolfgang Driever (55089)   +2 more
core   +1 more source

fgf3 gene expression is increased in cnot8^m1061 mutants.

, 2014
Analysis of fgf3 gene expression in cnot8m1061 mutants and WT siblings 2 dpf (A, B), and 3 dpf (C, D). All pictures show lateral views. Embryos were genotyped by PCR. Scale bar 100 µm.
Heiko B. Löhr (670637), Peter Koch (670636), Wolfgang Driever (55089)   +2 more
core   +1 more source