A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C. [PDF]
, 2015 The regulation of protein and mRNA turnover is essential for many cellular processes. We recently showed that ubiquitin--traditionally linked to protein degradation--directly regulates the degradation of mRNAs through the action of a newly identified ...
Cano, Florencia +3 more
core +3 more sources
A network‐based variable selection approach for identification of modules and biomarker genes associated with end‐stage kidney disease [PDF]
, 2020 AimsIntervention for end‐stage kidney disease (ESKD), which is associated with adverse prognoses and major economic burdens, is challenging due to its complex pathogenesis.
Fu, Ping +6 more
core +1 more source
Gene Variants Involved in Nonsense-Mediated mRNA Decay Suggest a Role in Autism Spectrum Disorder [PDF]
, 2022 This article belongs to the Special Issue mRNA Metabolism in Health and DiseaseAutism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental condition with unclear etiology.
Marques, Ana Rita +6 more
core +1 more source
Dynamic Control of Dendritic mRNA Expression by CNOT7 Regulates Synaptic Efficacy and Higher Cognitive Function [PDF]
, 2017 Translation of mRNAs in dendrites mediates synaptic plasticity, the probable cellular basis of learning and memory. Coordination of translational inhibitory and stimulatory mechanisms, as well as dendritic transport of mRNA, is necessary to ensure proper
Mansur, Fernanda +2 more
core +3 more sources
Genome-wide identification of CBX2 targets: insights in the human sex development network [PDF]
, 2015 CBX2 (Chromobox homolog 2) is a chromatin modifier that plays an important role in sexual development and its disorders (disorders of sex development, DSD), yet the exact rank and function of human CBX2 in this pathway remains unclear. Here, we performed
Biason-Lauber, Anna +2 more
core +1 more source
Combinatorial CRISPR screen identifies fitness effects of gene paralogues. [PDF]
, 2021 Genetic redundancy has evolved as a way for human cells to survive the loss of genes that are single copy and essential in other organisms, but also allows tumours to survive despite having highly rearranged genomes.
Adams, David J +21 more
core +1 more source
Multi-label multi-instance transfer learning for simultaneous reconstruction and cross-talk modeling of multiple human signaling pathways [PDF]
, 2015 Text file contains the predicted cross-talk signaling components between human signaling pathways (homolog instance).
Hao Zhu, Suyu Mei
core +12 more sources
The CCR4-NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression. [PDF]
Nat Commun, 2020 A repertoire of T cells with diverse antigen receptors is selected in the thymus. However, detailed mechanisms underlying this thymic positive selection are not clear.
Ito-Kureha T +13 more
europepmc +3 more sources
Tumor suppressors BTG1 and BTG2: Beyond growth control
Journal of Cellular Physiology, Volume 234, Issue 5, Page 5379-5389, May 2019., 2019 Members of the B‐cell translocation gene (BTG) protein family are important regulators of cellular differentiation and maintenance of homeostasis under conditions of cellular stress. This review describes these and other cellular functions, and highlights their emerging roles as potential tumor suppressors.
Laurensia Yuniati +3 more
wiley +1 more source
The DDX6-4E-T interaction mediates translational repression and P-body assembly [PDF]
, 2017 This is the final version of the article. Available from the publisher via the DOI in this record.4E-Transporter binds eIF4E via its consensus sequence YXXXXLΦ, shared with eIF4G, and is a nucleocytoplasmic shuttling protein found enriched in P ...
Broomhead, H +9 more
core +1 more source