A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors [PDF]
, 2016 One recurring theme in drug development is to exploit synthetic lethal properties as means to preferentially damage the DNA of cancer cells. We and others have previously developed inhibitors of the ATR kinase, shown to be particularly genotoxic for ...
Fernandez-Capetillo, Oscar +6 more
core +2 more sources
Advanced Science, Volume 12, Issue 21, June 5, 2025.Box C/D snoRNP complex regulates protein translation. This study identifies ZNHIT3 as a key component of the complex and ensures normal protein expression, including transcription factors orchestrating cell fate commitment, during early mouse embryogenesis.
Guanghui Yang, Qiliang Xin, Jurrien Dean
wiley +1 more source
RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-kappa B pathway [PDF]
, 2015 The RNA-binding protein RC3H1 (also known as ROQUIN) promotes TNF alpha mRNA decay via a 3'UTR constitutive decay element (CDE). Here we applied PAR-CLIP to human RC3H1 to identify similar to 3, 800 mRNA targets with 416, 000 binding sites.
Backofen, Rolf +17 more
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The role of RNA Polymerase II-dependent transcription elongation in the cross-talk between mRNA synthesis and decay. [PDF]
, 2018 The main molecule in gene expression is messenger RNA (mRNA) which transfers the information contained in genes in the nucleus to the cytoplasm where it is translated into proteins that carry out cellular functions. mRNA levels are determined through its
Begley, Victoria Sarah
core
Genome-Wide CRISPR-Cas9 Screen Analyzed by SLIDER Identifies Network of Repressor Complexes That Regulate TRIM24 [PDF]
, 2023 TRIM24 is an oncogenic chromatin reader that is frequently overexpressed in human tumors and associated with poor prognosis. However, TRIM24 is rarely mutated, duplicated, or rearranged in cancer.
Allton, Kendra +8 more
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Functional Analysis of CCR4-NOT Complex in Pancreatic β Cell [PDF]
, 2020 Functional analysis of CCR4-NOT complex in pancreatic β cellPancreatic β cells are responsible for production and secretion of insulin in response to increasing blood glucose levels.
Dina Mostafa
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Phenanthroline treated MSC [PDF]
, 2013 The invention relates to the field of medicine and in particular to the treatment of ischemia and to angiogenesis. The invention further relates to novel uses of phenanthroline in replacing a missing biological structure, supporting a damaged biological ...
Boer, J. de +3 more
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Ruolo del sistema ubiquitina-proteasoma (UPS) nella disfunzione beta cellulare del diabete di tipo 2 e possibili opzioni terapeutiche. [PDF]
, 2011 Ruolo del sistema ubiquitina-proteasoma (UPS) nella disfunzione beta cellulare del diabete di tipo 2 e possibili opzioni terapeutiche. Sebbene la disfunzione beta cellulare rivesta un ruolo di primaria importanza nel diabete di tipo 2, le informazioni ad
BUGLIANI, MARCO
core
The Role of the CNOT3 Subunit of the CCR4-NOT Complex in Cellular Senescence [PDF]
Okinawa Institute of Science and Technology Graduate UniversityDoctor of PhilosophyCellular senescence is a fundamentally irreversible cell cycle arrest associated with upregulated inflammatory responses.
Maipas, Aisulu
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Role of Cnot3 in gene regulation and cell cycle progression [PDF]
, 2015 Gene expression is a process that is tightly regulated by many factors. Different genes are transcribed not only in a cell specific manner but are also differentially expressed at different stages of the cell cycle.
Martufi, Matteo
core +1 more source