Results 51 to 60 of about 572 (99)

Analysis of the Ccr4-Not deadenylase complex: a biochemical and computational approach [PDF]

, 2017
In eukaryotic cells, the degradation of the mRNA poly(A) tail (deadenylation) is a crucial step in the regulation of gene expression. The Ccr4-Not complex is the major deadenylase enzyme involved in the mRNA deadenylation.
Balacco, Dario Leonardo
core  

Integrated Deadenylase Genetic Association Network and Transcriptome Analysis in Thoracic Carcinomas. [PDF]

Molecules, 2022
Kyritsis A, Papanastasi E, Kokkori I, Maragozidis P, Chatzileontiadou DSM, Pallaki P, Labrou M, Zarogiannis SG, Chrousos GP, Vlachakis D, Gourgoulianis KI, Balatsos NAA.   +11 more
europepmc   +1 more source

overexpression in HEK 293T cells

, 2019
Background The human orphan receptor TLX (NR2E1) is a key regulator of neurogenesis, adult stem cell maintenance, and tumorigenesis. However, little is known about the genetic and transcriptomic events that occur following TLX overexpression in human ...
Dzeneta Vizlin‐Hodzic, Funa, Keiko,, Vizlin-Hodzic, Dzeneta,, Salmela, Susanne,, Susanne Salmela, Keiko Funa, Parris, Toshima Z,, Toshima Z. Parris   +7 more
core   +1 more source

BTG2/PC3/Tis21 decreases Bcl-xL mRNA stability in cancer cells

, 2014
BTG2/PC3/Tis21, as one of the human BTG/TOB protein family members, comprises six members (BTG1, BTG2, BTG3, BTG4, TOB1 and TOB2) that are characterised by a conserved BTG domain containing box A and box B.
Lim, InKyoung, Choi, YongWon
core   +1 more source

The CCR4-NOT complex suppresses untimely translational activation of maternal mRNAs.

Development, 2023
Soeda S, Oyama M, Kozuka-Hata H, Yamamoto T.   +3 more
europepmc   +1 more source

Molecular analysis of the Ccr4-Not deadenylase: relevance to human disease [PDF]

, 2017
In eukaryotes, the removal of the poly (A) tail of cytoplasmic mRNA (deadenylation) is a crucial step in post-transcriptional gene regulation. A major enzyme involved in regulated mRNA deadenylation is the Ccr4-Not deadenylase, which contains two ...
Airhihen, Blessing
core  

CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection. [PDF]

EMBO Rep, 2023
Burgess HM, Grande R, Riccio S, Dinesh I, Winkler GS, Depledge DP, Mohr I.   +6 more
europepmc   +1 more source

BESST: a novel LncRNA knockout strategy with less genome perturbance. [PDF]

Nucleic Acids Res, 2023
Zhang S, Chen Y, Dong K, Zhao Y, Wang Y, Wang S, Qu C, Xu N, Xie W, Zeng C, Lyu QR, Zhang Y.   +11 more
europepmc   +1 more source

Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation.

Mol Cell, 2023
Höpfler M, Absmeier E, Peak-Chew SY, Vartholomaiou E, Passmore LA, Gasic I, Hegde RS.   +6 more
europepmc   +2 more sources

Torpor-Induced Regulation of Poly(A) Tail Machinery in 13-Lined Ground Squirrel Brown Adipose Tissue. [PDF]

J Dev Biol
Rehman S, Willmore WG, Storey KB.
europepmc   +1 more source