cnot8m1061 mutant embryos are not generally delayed in development.
, 2014 Gene expression analysis of emx1, fgf8 and krox20/egr2b in cnot8m1061 mutants and wild-type siblings at 1, 2 and 3 dpf. (A–F) emx1, (G–L) fgf8 and (M–R) krox20/egr2b. Embryos were genotyped by PCR. All pictures show lateral views. Scale bars 100 µm.
Heiko B. Löhr (670637) +2 more
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sim1a, otpa and nkx2.1a expression in cnot8m1061 embryos and WT siblings.
, 2014 Analysis of otpa (A–D), sim1a (E, F) and nkx2.1a (G–J) gene expression in cnot8m1061 mutant embryos and wild-type siblings, stages as indicated. (A–F, I, J) lateral views. (G, H) dorsal views. Embryos were genotyped by PCR. Scale bar 100 µm.
Heiko B. Löhr (670637) +2 more
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A network‐based variable selection approach for identification of modules and biomarker genes associated with end‐stage kidney disease [PDF]
, 2020 AimsIntervention for end‐stage kidney disease (ESKD), which is associated with adverse prognoses and major economic burdens, is challenging due to its complex pathogenesis.
Hyokyoung G. Hong +13 more
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The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module [PDF]
, 2015 In eukaryotic cells, the shortening and removal of the poly(A) tail (deadenylation) of cytoplasmic mRNA is a key event in regulated mRNA degradation. A major enzyme involved in deadenylation is the Ccr4-Not deadenylase complex, which can be recruited to ...
Airhihen, Blessing +2 more
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Biochemical analysis of the BTG1 variants associated with Non-Hodgkin’s lymphoma [PDF]
, 2017 Non-Hodgkin’s lymphoma (NHL) is a group of lympho-proliferative disorders characterised by genetic mutations resulting in the selection of a malignant clone.
Almasmoum, Hibah
core
The CCR4–NOT complex suppresses untimely translational activation of maternal mRNAs [PDF]
Control of mRNA poly(A) tails is essential for regulation of mRNA metabolism, specifically translation efficiency and mRNA stability. Gene expression in maturing oocytes relies largely on post-transcriptional regulation, as genes are transcriptionally ...
Yamamoto, Tadashi +3 more
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Regulation of mRNA poly(A) tail length governs mammalian body plan formation in gastruloids
The establishment of the body plan during gastrulation represents a hallmark of animal life. It emerges from the interplay of gene-regulatory programs and positional cues, yet how these signals are integrated post-transcriptionally remains largely ...
Katie Hyams +19 more
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Analysis of the Ccr4-Not deadenylase complex: a biochemical and computational approach [PDF]
In eukaryotic cells, the degradation of the mRNA poly(A) tail (deadenylation) is a crucial step in the regulation of gene expression. The Ccr4-Not complex is the major deadenylase enzyme involved in the mRNA deadenylation.
Balacco, Dario Leonardo
core +3 more sources
Biochemical analysis of the BTG1 variants associated with Non-Hodgkin’s lymphoma [PDF]
Non-Hodgkin’s lymphoma (NHL) is a group of lympho-proliferative disorders characterised by genetic mutations resulting in the selection of a malignant clone.
Almasmoum, Hibah
core +2 more sources
, 2011 A key step in cytoplasmic mRNA degradation is the shortening of the poly(A) tail, which involves several deadenylase enzymes. Relatively little is known about the importance of these enzymes for the cellular physiology.
Akhmed Aslam +4 more
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