Results 41 to 50 of about 948 (123)

1‐Hydroxy‐xanthine derivatives inhibit the human Caf1 nuclease and Caf1‐containing nuclease complexes via Mg2+‐dependent binding

FEBS Open Bio, Volume 9, Issue 4, Page 717-727, April 2019., 2019
We describe the use of AMP detection to measure the biochemical activity of deadenylase enzymes and show its utility by determining the inhibitory activity of 1‐hydroxy‐xanthines versus the Caf1 subunit, or subcomplexes of Ccr4‐Not containing the Caf1 and Ccr4 subunits.
Blessing Airhihen, Lorenzo Pavanello, Gopal P. Jadhav, Peter M. Fischer, Gerlof Sebastiaan Winkler   +4 more
wiley   +1 more source

Global gene expression analysis of early response to chemotherapy treatment in ovarian cancer spheroids [PDF]

, 2008
Background Chemotherapy (CT) resistance in ovarian cancer (OC) is broad and encompasses diverse unrelated drugs, suggesting more than one mechanism of resistance.
Tetu Bernard, Bachvarova Magdalena, L'Espérance Sylvain, Mes-Masson Anne-Marie, Bachvarov Dimcho   +4 more
core   +2 more sources

A New Network‐Based Strategy for Predicting the Potential miRNA‐mRNA Interactions in Tumorigenesis

International Journal of Genomics, Volume 2017, Issue 1, 2017., 2017
MicroRNA (miRNA) plays an important role in the degradation and inhibition of mRNAs and is a kind of essential drug targets for cancer therapy. To facilitate the clinical cancer research, we proposed a network‐based strategy to identify the cancer‐related miRNAs and to predict their targeted genes based on the gene expression profiles. The strategy was
Jiwei Xue, Fanfan Xie, Junmei Xu, Yuan Liu, Yu Liang, Zhining Wen, Menglong Li, Brian Wigdahl   +7 more
wiley   +1 more source

Identification of Candidate Genes Related to Inflammatory Bowel Disease Using Minimum Redundancy Maximum Relevance, Incremental Feature Selection, and the Shortest‐Path Approach

BioMed Research International, Volume 2017, Issue 1, 2017., 2017
Identification of disease genes is a hot topic in biomedicine and genomics. However, it is a challenging problem because of the complexity of diseases. Inflammatory bowel disease (IBD) is an idiopathic disease caused by a dysregulated immune response to host intestinal microflora.
Fei Yuan, Yu-Hang Zhang, Xiang-Yin Kong, Yu-Dong Cai, Mikihiro Fujiya   +4 more
wiley   +1 more source

Role of Cnot6l in maternal mRNA turnover. [PDF]

, 2018
Removal of poly(A) tail is an important mechanism controlling eukaryotic mRNA turnover. The major eukaryotic deadenylase complex CCR4-NOT contains two deadenylase components, CCR4 and CAF1, for which mammalian CCR4 is encoded by Cnot6 or Cnot6l paralogs.
Fulka, Helena, Horvat, Filip, Jankele, Radek, Jun, Ma, Malik, Radek, Schultz, Richard, Sedlacek, Radislav, Solcova, Katerina, Svoboda, Petr, Vlahovicek, Kristian   +9 more
core   +1 more source

The Ccr4‐Not complex is a key regulator of eukaryotic gene expression

WIREs RNA, Volume 7, Issue 4, Page 438-454, July/August 2016., 2016
The Ccr4‐Not complex is a multisubunit complex present in all eukaryotes that contributes to regulate gene expression at all steps, from production of messenger RNAs (mRNAs) in the nucleus to their degradation in the cytoplasm. In the nucleus it influences the post‐translational modifications of the chromatin template that has to be remodeled for ...
Martine A. Collart
wiley   +1 more source

Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4–Not deadenylase in non-Hodgkin lymphoma [PDF]

, 2020
© 2020 Informa UK Limited, trading as Taylor & Francis Group. Mutations in the highly similar genes B-cell translocation gene 1 (BTG1) and BTG2 are identified in approximately 10–15% of non-Hodgkin lymphoma cases, which may suggest a direct involvement
Airhihen, Blessing, Almasmoum, Hibah, Seedhouse, Claire, Winkler, Gerlof Sebastiaan   +3 more
core   +2 more sources

Cytotoxicity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine

Evidence-Based Complementary and Alternative Medicine, Volume 2013, Issue 1, 2013., 2013
Aim. The present study was designed to investigate the cytotoxicity of a panel of 280 Korean medicinal plants belonging to 73 families and 198 species against human CCRF‐CEM leukemia cells. Selected phytochemicals were investigated in more detail for their mode of action. Methods.
Victor Kuete, Ean-Jeong Seo, Benjamin Krusche, Mira Oswald, Benjamin Wiench, Sven Schröder, Henry Johannes Greten, Ik-Soo Lee, Thomas Efferth, Sookyung Lee   +9 more
wiley   +1 more source

Ubiquitination‐Dependent LLGL2 Degradation Drives Colorectal Cancer Progression via THBS3 mRNA Stabilization

Advanced Science, Volume 12, Issue 39, October 20, 2025.
During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang, Tiantian Zhang, Huimin Li, Zidan Li, Shuangshuang Yin, Yiman Liu, Chunze Zhang, Yuling Qiu, Haiyang Yu   +8 more
wiley   +1 more source

eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5'UTR [PDF]

, 2019
Background: Regulation of the mRNA life cycle is central to gene expression control and determination of cell fate. miRNAs represent a critical mRNA regulatory mechanism, but despite decades of research, their mode of action is still not fully understood.
Bushell, Martin, Cain, Kelvin, Gillen, Sarah L., Godfrey, Jack D., Hawley, Benjamin R., Hodge, Kelly, Jukes-Jones, Rebekah, Kopra, Kari, Langlais, Claudia, Le Quesne, John, Lu, Wei-Ting, Meijer, Hedda A., Schmidt, Tobias, Wilczynska, Ania, Zanivan, Sara   +14 more
core   +3 more sources