Results 21 to 30 of about 948 (123)

Differential gene expression of blood-based ABCA9, CNOT8, SESN1, UCP3, MAP2K1 and DDIT4 in Alzheimer’s disease

Neuroscience Research Notes, 2023
This study uncovered differential gene expression in blood to distinguish subjects with probable Alzheimer’s disease (AD) from normal elderly participants (non-demented controls, NDC). The participants were recruited via training (Phase 1) and validation cohorts (Phase 2).
Ainon Zahariah Samsudin, Kalavathy Ramasamy, Siong Meng Lim, Ai Vyrn Chin, Maw Pin Tan, Shahrul Bahyah Kamaruzzaman, Baharudin Ibrahim, Abu Bakar Abdul Majeed   +7 more
openaire   +1 more source

MEK1 is associated with carboplatin resistance and is a prognostic biomarker in epithelial ovarian cancer [PDF]

, 2014
BACKGROUND: Primary systemic treatment for ovarian cancer is surgery, followed by platinum based chemotherapy. Platinum resistant cancers progress/recur in approximately 25% of cases within six months. We aimed to identify clinically useful biomarkers of
Denkert C, Győrffy, Balázs, Krenács, Tibor, Lánczky A, Lénárt J, Meggyesházi, Nóra, Pete, Imre, Pénzváltó, Zsófia, Szoboszlai, Norbert   +8 more
core   +2 more sources

Post-transcriptional control of tumor cell autonomous metastatic potential by the CCR4-NOT deadenylase CNOT7 [PDF]

, 2016
Accumulating evidence supports the role of an aberrant transcriptome as a driver of metastatic potential. Deadenylation is a general regulatory node for post-transcriptional control by microRNAs and other determinants of RNA stability.
A Aslam, A Boland, A Charlesworth, A Suzuki, A Yamashita, AM Zubiaga, AP Petit, B Loh, C Chen, CJ Aslakson, CJ Decker, CT Guy, E Wahle, EE Schadt, EJ Chesler, F Faraji, F Faraji, Farhoud Faraji, G. Sebastian Winkler, GS Winkler, H Sandler, Howard H. Yang, I Behm-Ansmant, IJ Fidler, J Van Etten, J Yang, K Ito, K Ito, K Ogami, K Ryan, Kent W. Hunter, KJ Luzzi, L Lukes, L Ma, Laura Corbo, M Fenger-Gron, M Horiuchi, M Maekawa, M Ringner, M Tucker, MA Collart, MA Collart, Markus Hafner, Maxwell P. Lee, MW Helms, N Hosoda, NC Lau, NP Crawford, P Viswanathan, RP Wharton, S Jayne, S Matsuda, S Mittal, S Valastyan, SA Mani, SF Tavazoie, SF Winter, T Lifsted, T Nakamura, TK Albert, W Joly, X Li, X Zheng, XF Pei, Y Funakoshi, Ying Hu   +65 more
core   +4 more sources

Nonsense‐mediated decay factor SMG7 sensitizes cells to TNFα‐induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1

Molecular Oncology, Volume 14, Issue 10, Page 2420-2435, October 2020., 2020
Yang et al. found that mutation of the nonsense‐mediated decay factor SMG7 enhanced resistance to tumor necrosis factor (TNF)‐induced apoptosis via two oncogenic pathways. Downregulation of CYLD and overexpression of the long noncoding RNA Pvt1 converge to promote NF‐κB activation.
Limeng Yang, Vanessa A. N. Kraft, Susanne Pfeiffer, Juliane Merl‐Pham, Xuanwen Bao, Yu An, Stefanie M. Hauck, Joel A. Schick   +7 more
wiley   +1 more source

Global gene expression in endometrium of high and low fertility heifers during the mid-luteal phase of the estrous cycle [PDF]

, 2014
peer-reviewedBackground In both beef and dairy cattle, the majority of early embryo loss occurs within the first 14 days following insemination.
Diskin, Michael G., Kenny, David A., Killeen, Aideen P., Morris, Dermot G., Mullen, Michael P., Waters, Sinead M.   +5 more
core   +1 more source

Integrated Analysis of a Gene Correlation Network Identifies Critical Regulation of Fibrosis by lncRNAs and TFs in Idiopathic Pulmonary Fibrosis

BioMed Research International, Volume 2020, Issue 1, 2020., 2020
Idiopathic pulmonary fibrosis (IPF), the most frequent form of irreversible interstitial pneumonia with unknown etiology, is characterized by massive remodeling of lung architecture and followed by progressive loss of lung function. However, the key regulatory genes and the specific signaling pathways involved in the onset and progression of IPF still ...
Fan Wang, Pei Li, Feng-sen Li, Brandi L. Cantarel   +3 more
wiley   +1 more source

Cell cycle RNA regulons coordinating early lymphocyte development [PDF]

, 2017
Lymphocytes undergo dynamic changes in gene expression as they develop from progenitor cells lacking antigen receptors, to mature cells that are prepared to mount immune responses.
Abdelmohsen, Achsel, Al-Haj, Bayeva, Bell, Bellavia, Benjamin, Blackinton, Blackinton, Brooks, Chen, Chen, Ciais, Ciofani, Clark, DeMicco, DeMicco, Diaz-Munoz, Fabian, Fallahi, Fuxa, Galloway, Gerstberger, Ghosh, Gruber, Gunzburg, Guo, Hacker, Haks, Halees, Hausburg, Heng, Herranz, Higashi, Hitti, Hodson, Horner, Inoue, Johnson, Keene, Kelly, Khabar, Kim, Kotta-Loizou, Kratochvill, Kreslavsky, Kullmann, Laurenti, Lu, Ma, Masamha, Meisner, Mijuskovic, Miskimins, Montorsi, Mukherjee, Mukherjee, Mukherjee, Muralidharan, Ochiai, Pang, Papadaki, Papaemmanuil, Patial, Pedraza-Alva, Raghavan, Rodriguez, Ross, Rounbehler, Sandler, Sanduja, Schmidlin, Sedlyarov, Selmi, Sinha, Spencer, Stoecklin, Stubbington, Stumpo, Stumpo, Techasintana, Thompson, Tiedje, Tiedje, Trigueros, Vigo, Vogel, Wang, Wei, Yang, Yao, Yasuda, Zhang, Zou, Zuniga-Pflucker   +94 more
core   +2 more sources

Poly(A) Tail Regulation in the Nucleus [PDF]

, 2022
Der Ribonukleinsäure (RNS) Stoffwechsel umfasst verschiedene Schritte, beginnend mit der Transkription der RNS über die Translation bis zum RNA Abbau.
Alles, Jonathan
core   +1 more source

Interaction of NANOS2 and NANOS3 with different components of the CNOT complex may contribute to the functional differences in mouse male germ cells

Biology Open, 2014
NANOS2 and NANOS3 belong to the Nanos family of proteins that contain a conserved zinc finger domain, which consists of two consecutive CCHC-type zinc finger motifs, and contribute to germ cell development in mice.
Atsushi Suzuki, Yuki Niimi, Yumiko Saga
doaj   +1 more source

A compendium of synthetic lethal gene pairs defined by extensive combinatorial pan-cancer CRISPR screening. [PDF]

Genome Biol
BACKGROUND: Synthetic lethal interactions are attractive therapeutic candidates as they enable selective targeting of cancer cells in which somatic alterations have disrupted one member of a synthetic lethal gene pair while leaving normal tissues ...
Harle V, Offord V, Gökbağ B, Fotopoulos L, Williams T, Alexander D, Mehta I, Thompson NA, Olvera-León R, Peidli S, Iyer V, Gonçalves E, Kebabci N, De Kegel B, van de Haar J, Li L, Ryan CJ, Adams DJ.   +17 more
europepmc   +3 more sources