Results 21 to 30 of about 529 (83)

Tumor suppressors BTG1 and BTG2: Beyond growth control

Journal of Cellular Physiology, Volume 234, Issue 5, Page 5379-5389, May 2019., 2019
Members of the B‐cell translocation gene (BTG) protein family are important regulators of cellular differentiation and maintenance of homeostasis under conditions of cellular stress. This review describes these and other cellular functions, and highlights their emerging roles as potential tumor suppressors.
Laurensia Yuniati, Blanca Scheijen, Laurens T. van der Meer, Frank N. van Leeuwen   +3 more
wiley   +1 more source

1‐Hydroxy‐xanthine derivatives inhibit the human Caf1 nuclease and Caf1‐containing nuclease complexes via Mg2+‐dependent binding

FEBS Open Bio, Volume 9, Issue 4, Page 717-727, April 2019., 2019
We describe the use of AMP detection to measure the biochemical activity of deadenylase enzymes and show its utility by determining the inhibitory activity of 1‐hydroxy‐xanthines versus the Caf1 subunit, or subcomplexes of Ccr4‐Not containing the Caf1 and Ccr4 subunits.
Blessing Airhihen, Lorenzo Pavanello, Gopal P. Jadhav, Peter M. Fischer, Gerlof Sebastiaan Winkler   +4 more
wiley   +1 more source

A New Network‐Based Strategy for Predicting the Potential miRNA‐mRNA Interactions in Tumorigenesis

International Journal of Genomics, Volume 2017, Issue 1, 2017., 2017
MicroRNA (miRNA) plays an important role in the degradation and inhibition of mRNAs and is a kind of essential drug targets for cancer therapy. To facilitate the clinical cancer research, we proposed a network‐based strategy to identify the cancer‐related miRNAs and to predict their targeted genes based on the gene expression profiles. The strategy was
Jiwei Xue, Fanfan Xie, Junmei Xu, Yuan Liu, Yu Liang, Zhining Wen, Menglong Li, Brian Wigdahl   +7 more
wiley   +1 more source

Identification of Candidate Genes Related to Inflammatory Bowel Disease Using Minimum Redundancy Maximum Relevance, Incremental Feature Selection, and the Shortest‐Path Approach

BioMed Research International, Volume 2017, Issue 1, 2017., 2017
Identification of disease genes is a hot topic in biomedicine and genomics. However, it is a challenging problem because of the complexity of diseases. Inflammatory bowel disease (IBD) is an idiopathic disease caused by a dysregulated immune response to host intestinal microflora.
Fei Yuan, Yu-Hang Zhang, Xiang-Yin Kong, Yu-Dong Cai, Mikihiro Fujiya   +4 more
wiley   +1 more source

The Ccr4‐Not complex is a key regulator of eukaryotic gene expression

WIREs RNA, Volume 7, Issue 4, Page 438-454, July/August 2016., 2016
The Ccr4‐Not complex is a multisubunit complex present in all eukaryotes that contributes to regulate gene expression at all steps, from production of messenger RNAs (mRNAs) in the nucleus to their degradation in the cytoplasm. In the nucleus it influences the post‐translational modifications of the chromatin template that has to be remodeled for ...
Martine A. Collart
wiley   +1 more source

Cytotoxicity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine

Evidence-Based Complementary and Alternative Medicine, Volume 2013, Issue 1, 2013., 2013
Aim. The present study was designed to investigate the cytotoxicity of a panel of 280 Korean medicinal plants belonging to 73 families and 198 species against human CCRF‐CEM leukemia cells. Selected phytochemicals were investigated in more detail for their mode of action. Methods.
Victor Kuete, Ean-Jeong Seo, Benjamin Krusche, Mira Oswald, Benjamin Wiench, Sven Schröder, Henry Johannes Greten, Ik-Soo Lee, Thomas Efferth, Sookyung Lee   +9 more
wiley   +1 more source

Ubiquitination‐Dependent LLGL2 Degradation Drives Colorectal Cancer Progression via THBS3 mRNA Stabilization

Advanced Science, Volume 12, Issue 39, October 20, 2025.
During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang, Tiantian Zhang, Huimin Li, Zidan Li, Shuangshuang Yin, Yiman Liu, Chunze Zhang, Yuling Qiu, Haiyang Yu   +8 more
wiley   +1 more source

Mutation of Brain Aromatase Impairs Behavior and Neuroplasticity in Adult Zebrafish

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
This study investigates the functional role of brain aromatase, encoded by the cyp19a1b gene, in zebrafish neurodevelopment and adult behavior. Using TALENs technology, we introduced a 10‐nucleotide deletion in exon 2, generating a zebrafish line that expresses a truncated aromatase protein.
Cassandra Malleret, Mélanie Blanc‐Legendre, Laëtitia Guillot, Harmony Lautrette‐Quinveros, Pavlina Pavlidi, Christina Dalla, Nikos Kokras, François Brion, Maryne Toupin, Frédéric Chalmel, Xavier Cousin, Thierry Dominique Charlier, Elisabeth Pellegrini   +12 more
wiley   +1 more source

ZNHIT3 Regulates Translation to Ensure Cell Lineage Differentiation in Mouse Preimplantation Development

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Box C/D snoRNP complex regulates protein translation. This study identifies ZNHIT3 as a key component of the complex and ensures normal protein expression, including transcription factors orchestrating cell fate commitment, during early mouse embryogenesis.
Guanghui Yang, Qiliang Xin, Jurrien Dean
wiley   +1 more source

The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7)/Caf1b (CNOT8) deadenylase enzymes [PDF]

, 2013
The human BTG/TOB protein family comprises six members (BTG1, BTG2/PC3/Tis21, BTG3/Ana, BTG4/PC3B, TOB1/Tob, and TOB2) that display anti-proliferative activity in a number of cell types. They are characterised by a conserved N-terminal BTG domain that mediates interactions with the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylases.
openaire   +1 more source