Results 21 to 30 of about 572 (99)

Copy number variations contribute to malignant tumor development in children with serious birth defects. [PDF]

Mol Oncol
Children with birth defects are more likely to develop cancer. We observed strong heterogeneity and uneven distributions of copy number variations (CNVs) in 454 such children, with limited occurrence of cancer predisposition genes. However, consistency of the functional impact of CNVs on pathways, and enrichment of non‐coding RNA, was observed, showing
Liu Y, Glessner J, Qu HQ, Chang X, Qiu H, Wang T, Mentch FD, Hakonarson H.   +7 more
europepmc   +2 more sources

Integrated Analysis of a Gene Correlation Network Identifies Critical Regulation of Fibrosis by lncRNAs and TFs in Idiopathic Pulmonary Fibrosis

BioMed Research International, Volume 2020, Issue 1, 2020., 2020
Idiopathic pulmonary fibrosis (IPF), the most frequent form of irreversible interstitial pneumonia with unknown etiology, is characterized by massive remodeling of lung architecture and followed by progressive loss of lung function. However, the key regulatory genes and the specific signaling pathways involved in the onset and progression of IPF still ...
Fan Wang, Pei Li, Feng-sen Li, Brandi L. Cantarel   +3 more
wiley   +1 more source

Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4–Not deadenylase in non-Hodgkin lymphoma [PDF]

, 2020
© 2020 Informa UK Limited, trading as Taylor & Francis Group. Mutations in the highly similar genes B-cell translocation gene 1 (BTG1) and BTG2 are identified in approximately 10–15% of non-Hodgkin lymphoma cases, which may suggest a direct involvement
Seedhouse, Claire, Winkler, Gerlof Sebastiaan, Almasmoum, Hibah, Airhihen, Blessing   +3 more
core   +1 more source

Tumor suppressors BTG1 and BTG2: Beyond growth control

Journal of Cellular Physiology, Volume 234, Issue 5, Page 5379-5389, May 2019., 2019
Members of the B‐cell translocation gene (BTG) protein family are important regulators of cellular differentiation and maintenance of homeostasis under conditions of cellular stress. This review describes these and other cellular functions, and highlights their emerging roles as potential tumor suppressors.
Laurensia Yuniati, Blanca Scheijen, Laurens T. van der Meer, Frank N. van Leeuwen   +3 more
wiley   +1 more source

1‐Hydroxy‐xanthine derivatives inhibit the human Caf1 nuclease and Caf1‐containing nuclease complexes via Mg2+‐dependent binding

FEBS Open Bio, Volume 9, Issue 4, Page 717-727, April 2019., 2019
We describe the use of AMP detection to measure the biochemical activity of deadenylase enzymes and show its utility by determining the inhibitory activity of 1‐hydroxy‐xanthines versus the Caf1 subunit, or subcomplexes of Ccr4‐Not containing the Caf1 and Ccr4 subunits.
Blessing Airhihen, Lorenzo Pavanello, Gopal P. Jadhav, Peter M. Fischer, Gerlof Sebastiaan Winkler   +4 more
wiley   +1 more source

A New Network‐Based Strategy for Predicting the Potential miRNA‐mRNA Interactions in Tumorigenesis

International Journal of Genomics, Volume 2017, Issue 1, 2017., 2017
MicroRNA (miRNA) plays an important role in the degradation and inhibition of mRNAs and is a kind of essential drug targets for cancer therapy. To facilitate the clinical cancer research, we proposed a network‐based strategy to identify the cancer‐related miRNAs and to predict their targeted genes based on the gene expression profiles. The strategy was
Jiwei Xue, Fanfan Xie, Junmei Xu, Yuan Liu, Yu Liang, Zhining Wen, Menglong Li, Brian Wigdahl   +7 more
wiley   +1 more source

The live phenotype and positional cloning of the cnot8^m1061 mutation.

, 2014
(A) Comparison of cnot8m1061 mutant to wild-type sibling embryos at 5 dpf; cnot8m1061 mutants display edema formation in the eyes and brain (top row, arrowheads) as well as cardiac and yolk sac (bottom row, arrowhead).
Heiko B. Löhr (670637), Peter Koch (670636), Wolfgang Driever (55089)   +2 more
core   +1 more source

Identification of Candidate Genes Related to Inflammatory Bowel Disease Using Minimum Redundancy Maximum Relevance, Incremental Feature Selection, and the Shortest‐Path Approach

BioMed Research International, Volume 2017, Issue 1, 2017., 2017
Identification of disease genes is a hot topic in biomedicine and genomics. However, it is a challenging problem because of the complexity of diseases. Inflammatory bowel disease (IBD) is an idiopathic disease caused by a dysregulated immune response to host intestinal microflora.
Fei Yuan, Yu-Hang Zhang, Xiang-Yin Kong, Yu-Dong Cai, Mikihiro Fujiya   +4 more
wiley   +1 more source

The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7)/Caf1b (CNOT8) deadenylase enzymes [PDF]

The human BTG/TOB protein family comprises six members (BTG1, BTG2/PC3/Tis21, BTG3/Ana, BTG4/PC3B, TOB1/Tob, and TOB2) that display anti-proliferative activity in a number of cell types.
Doidge, Rachel L.
core   +3 more sources

The Ccr4‐Not complex is a key regulator of eukaryotic gene expression

WIREs RNA, Volume 7, Issue 4, Page 438-454, July/August 2016., 2016
The Ccr4‐Not complex is a multisubunit complex present in all eukaryotes that contributes to regulate gene expression at all steps, from production of messenger RNAs (mRNAs) in the nucleus to their degradation in the cytoplasm. In the nucleus it influences the post‐translational modifications of the chromatin template that has to be remodeled for ...
Martine A. Collart
wiley   +1 more source