Results 61 to 70 of about 948 (123)

Molecular and Physiological function of the mammalian CCR4-NOT subunit CNOT9 [PDF]

, 2020
Messenger RNA (mRNA) decay is an indisputable component of gene expression regulation. In higher eukaryotes such as humans and mice, this process is mainly governed by a multi-subunit protein assemblage known as the CCR4-NOT complex.
Hemanta Sarmah
core   +1 more source

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci [PDF]

, 2016
Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA.
Abbate, R, Baas, AF, Badger, SA, Bailey, MA, Betsholtz, C, Bjorkegren, JLM, Blair, R, Blankensteijn, JD, Borthwick, KM, Bottinger, EP, Bown, MJ, Bradley, DT, Bridge, K, Bumpstead, S, Carey, DJ, Carrell, DS, Clough, RE, Cockerill, G, Consortium, C, Courtois, A, Crawford, DC, Crosslin, DR, de Andrade, M, de Bakker, PIW, de Graaf, J, de Vries, J-P, Deloukas, P, Drolet, AM, Eicher, JD, Elmore, JR, Erdman, R, Eriksson, P, Ferrell, RE, Folkersen, L, Franco-Cereceda, A, Franklin, DP, Franzen, O, Futers, TS, Galora, S, Geelkerken, RH, Gerhard, GS, Giusti, B, Golledge, J, Goodall, AH, Gottesman, O, Gretarsdottir, S, Griffin, KJ, Hafez, H, Hamby, SE, Harrison, SC, Hill, AA, Hill, GB, Hughes, A, Humphries, SE, Johnson, AD, Jones, GT, Kiemeney, LA, Krysa, J, Kuivaniemi, H, Kullo, IJ, Lewis, DR, Lindholt, JS, Lipovich, L, Malinowski, J, Matthiasson, SE, McCarty, CA, Merriman, TR, Nelson, CP, Norman, PE, Oszkinis, G, Pacheco, JA, Peissig, PL, Pendergrass, S, Phillips, VL, Powell, JT, Pratesi, C, Pressure, ICB, Pulli, R, Rasmussen-Torvik, LJ, Ritchie, MD, Roake, J, Romaine, SPR, Ruusalepp, A, Ryer, EJ, Sakalihasan, N, Samani, NJ, Saracini, C, Saratzis, A, Sayers, RD, Schadt, EE, Scott, DJA, Smelser, DT, Smith, A, Stefansson, K, Stirrups, K, Strauss, E, Teijink, JAW, Thompson, JR, Thompson, MM, Thomson, IA, Thorleifsson, G, Thorsteinsdottir, U, Tromp, G, van Bockxmeer, FM, van Rij, AM, van Sambeek, MR, van Sterkenburg, SM, van't Hof, FNG, Vasudevan, TM, Verhoeven, EL, Verissimo, AR, Verma, A, Verma, SS, Webb, TR, Wei, W, Wijmenga, C, Williams, MJA, Zeebregts, CJ, Zy, ZY   +118 more
core   +11 more sources

The CNOT complex contributes to the maintenance of genome stability [PDF]

, 2020
The yeast CCR4-NOT (CNOT in mammals) complex is a large (1.0-MDa) and highly conserved multifunctional set of proteins. It is involved in many different aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA ...
Chalabi Hagkarim, Nafiseh
core  

Ένζυμα μεταβολισμού RNA ως μοριακοί δείκτες καρκίνου [PDF]

, 2011
Τοτόμη, Αθηνά Γ.
core   +1 more source

Integrated Deadenylase Genetic Association Network and Transcriptome Analysis in Thoracic Carcinomas. [PDF]

Molecules, 2022
Kyritsis A, Papanastasi E, Kokkori I, Maragozidis P, Chatzileontiadou DSM, Pallaki P, Labrou M, Zarogiannis SG, Chrousos GP, Vlachakis D, Gourgoulianis KI, Balatsos NAA.   +11 more
europepmc   +1 more source

RNA-binding proteins in mouse male germline stem cells: a mammalian perspective [PDF]

, 2016

core   +1 more source

Coexpression Networks Based on Natural Variation in Human Gene Expression at Baseline and Under Stress [PDF]

, 2010
Genes interact in networks to orchestrate cellular processes. Here, we used coexpression networks based on natural variation in gene expression to study the functions and interactions of human genes.
Nayak, Renuka
core   +1 more source

CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex

CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex
The CCR4-NOT deadenylase complex is a major post-transcriptional regulator of eukaryotic gene expression. CNOT7 and CNOT8 are both vertebrate homologs of the yeast CCR4-NOT catalytic subunit Caf1. They are highly similar and are sometimes considered redundant, but Cnot7 and Cnot8 knockout mice exhibit different phenotypes, implying distinct ...
openaire  

Regulatory Mechanisms and RNA Targets of Human Pumilio Proteins. [PDF]

, 2013
Gene expression requires balance between synthesis and decay of mRNAs. Aberrant expression of genes results in disease. PUF proteins are a family of eukaryotic RNA binding regulators characterized by a conserved RNA binding domain that binds 8-12 ...
Van Etten, Jamie Lynn
core  

CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection. [PDF]

EMBO Rep, 2023
Burgess HM, Grande R, Riccio S, Dinesh I, Winkler GS, Depledge DP, Mohr I.   +6 more
europepmc   +1 more source