Results 81 to 90 of about 5,097 (156)

The Complement System of Agnathans

Frontiers in Immunology, 2018
Agnathans (lamprey and hagfish) are a group of primitive jawless fish. Jawed vertebrates possess adaptive immunity including immunoglobulins, while agnathans lack immunoglobulins but have alternative adaptive immunity in which variable lymphocyte ...
Misao Matsushita
doaj   +1 more source

Interaction of C1q With Pentraxin 3 and IgM Revisited: Mutational Studies With Recombinant C1q Variants

Frontiers in Immunology, 2019
Pentraxins and complement defense collagens are soluble recognition proteins that sense pathogens and altered-self elements, and trigger immune responses including complement activation.
Isabelle Bally, Antonio Inforzato, Antonio Inforzato, Fabien Dalonneau, Matteo Stravalaci, Matteo Stravalaci, Barbara Bottazzi, Christine Gaboriaud, Nicole M. Thielens   +8 more
doaj   +1 more source

Beneficial effects of omega-3 fatty acids in the proteome of high-density lipoprotein proteome

Lipids in Health and Disease, 2012
Background Omega-3 poly-unsaturated fatty acids (ω-3 PUFAs) have demonstrated to be beneficial in the prevention of cardiovascular disease, however, the mechanisms by which they perform their cardiovascular protection have not been clarified ...
Burillo Elena, Mateo-Gallego Rocío, Cenarro Ana, Fiddyment Sarah, Bea Ana M, Jorge Inmaculada, Vázquez Jesús, Civeira Fernando   +7 more
doaj   +1 more source

Complement classical and alternative pathway activation contributes to diabetic kidney disease progression: a glomerular proteomics on kidney biopsies

Scientific Reports
Increasing evidence points toward an essential role for complement activation in the pathogenesis of diabetic kidney disease (DKD). However, the precise molecular mechanisms remain unclear, and the pathway predominantly contributing to complement ...
Yang Yang, Ying Zhang, Yuan Li, Xinjin Zhou, Kazuho Honda, Dedong Kang, Muxi Wang, Jing-Hua Yang, Zongping Xia, Yuan Wei, Lu Liu, Ruimin Hu, Takashi Takaki, Guolan Xing   +13 more
doaj   +1 more source

Expression of complement factor C1r and C1s in human gingival fibroblasts

, 2023
Background: Periodontitis is an inflammatory condition rendering in degradation of tooth supporting tissue. In the inflammatory process cytokines, amongst others TNF-a, IL-1b and IL-6 play an important role in regulating the immune response. Periodontal Ehlers Danlos syndrome (pEDS) is a rare connective tissue disorder characterized by distinct oral ...
openaire   +1 more source

C1s targeting antibodies inhibit the growth of cutaneous squamous carcinoma cells

Scientific Reports
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. The incidence of cSCC is increasing globally and the prognosis of metastatic disease is poor.
Liisa Nissinen, Pilvi Riihilä, Kristina Viiklepp, Vaishnavi Rajagopal, Michael J. Storek, Veli-Matti Kähäri   +5 more
doaj   +1 more source

Comment on "Could signal peptide complement C1r/C1s, Uegf, and Bmp1, and epidermal growth factor-containing protein 1 be a therapeutic target in the pathogenesis of preeclampsia?" [PDF]

Rev Assoc Med Bras (1992)
Cheng C, Wang Y.
europepmc   +1 more source

Increased Serum Signal Peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial Growth Factor Domain-Containing Protein-1 May Have a Role in the Pathophysiology of Late-Onset Fetal Growth Restriction. [PDF]

Diagnostics (Basel)
Dinc G, Karahan SC, Guven S.
europepmc   +1 more source

Clinical presentations and molecular basis of complement C1R mutation in a large turkish family [PDF]

Pediatr Rheumatol Online J, 2014
Demirkaya E, Kasapcopur O, Barut K, Caliskan S, Polat A, Onen Y, Aksentijevich I.   +6 more
europepmc   +1 more source

Oxygen-dependent modulation of the human complement system during acute normobaric hypoxia: a translational plasma proteomics study. [PDF]

Clin Exp Med
Lang A, Pang TY, Piel S, Oehler D, Zweck E, Shahrjerdi K, Okkasian M, Georgy J, Reinders Y, Duplessis AJ, Tank J, Jordan J, Pfeiler S, Sickmann A, Kelm M, Jung C, Gerdes N.   +16 more
europepmc   +1 more source