Purified complement C3b triggers phagocytosis and activation of human neutrophils via complement receptor 1 [PDF]
Scientific Reports, 2023 The complement system provides vital immune protection against infectious agents by labeling them with complement fragments that enhance phagocytosis by immune cells.
Elena Boero +12 more
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Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood [PDF]
Frontiers in Immunology, 2022 IntroductionPlatelets have essential functions as first responders in the immune response to pathogens. Activation and aggregation of platelets in bacterial infections can lead to life-threatening conditions such as arterial thromboembolism or sepsis ...
Anne Landsem +14 more
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A novel and rapid method to purify the human complement opsonin C3b from human plasma [PDF]
Frontiers in ImmunologyComplement opsonin C3b is at the center of the complement cascade. All complement initiation pathways converge when convertases activate C3, converting it into the anaphylatoxin C3a and the opsonin C3b, which can attach to surfaces via its freshly ...
Jannik Sichau, Christoph Q. Schmidt
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In vitro complement activation via nucleocapsid and spike proteins of SARS-CoV-2 in COVID-19 patients [PDF]
Scientific ReportsIn the overactivation of the complement, the role of classical pathway is still not thoroughly investigated in COVID-19. Our aim was to examine the connection between SARS-CoV-2-specific antibodies, in vitro complement activation, and in vivo complement ...
Petra Kiszel +5 more
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Mutations in UMOD Contribute to the Pathogenesis of ADTKD-UMOD by Influencing the Function of Complement Factor H. [PDF]
J Cell Mol MedABSTRACT Tubular atrophy and interstitial fibrosis are basic renal pathological changes in autosomal dominant tubulointerstitial kidney disease (ADTKD). Reduced secretion or abnormal structure of uromodulin (UMOD) are recognised pathogenic factors of ADTKD.
Xie Q, Bai L, Gong K, Hu N, Chen Y.
europepmc +2 more sources
The Sand Fly Salivary Protein Lufaxin Inhibits the Early Steps of the Alternative Pathway of Complement by Direct Binding to the Proconvertase C3b-B [PDF]
Frontiers in Immunology, 2017 Saliva of the blood feeding sand fly Lutzomyia longipalpis was previously shown to inhibit the alternative pathway (AP) of the complement system. Here, we have identified Lufaxin, a protein component in saliva, as the inhibitor of the AP.
Antonio F. Mendes-Sousa +16 more
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Nuclear complement C3b promotes paclitaxel resistance by assembling the SIN3A/HDAC1/2 complex in non-small cell lung cancer. [PDF]
Cell Death Dis, 2023 Wang X +15 more
europepmc +3 more sources
The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases [PDF]
Frontiers in Immunology, 2021 The Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders.
Wen Q. Qiu +7 more
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Inhibition of Complement Will Substantially Reduce the Anemia of Malaria [PDF]
Journal of Immunology ResearchThere is compelling evidence that complement plays a major role in the elimination of nonparasitized erythrocytes (np-Es) in the anemia of malaria. In fact, for every erythrocyte destroyed after infection by Plasmodium falciparum (Pf) or Plasmodium vivax,
Ronald P. Taylor, Margaret A. Lindorfer
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Factor H binding proteins protect division septa on encapsulated Streptococcus pneumoniae against complement C3b deposition and amplification. [PDF]
Nat Commun, 2018 Pathak A +7 more
europepmc +3 more sources