Results 11 to 20 of about 12,786 (117)
Defining Targets for Complement Components C4b and C3b on the Pathogenic Neisseriae [PDF]
Infection and Immunity, 2008 ABSTRACTComplement is a key arm of the innate immune defenses against the pathogenic neisseriae. We previously identified lipooligosaccharide onNeisseria meningitidisas an acceptor for complement C4b. Little is known about other neisserial targets for complement proteins C3 and C4, which covalently attach to bacterial surfaces and initiate opsonization
Lewis, Lisa A. +7 more
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Structure of complement fragment C3b–factor H and implications for host protection by complement regulators [PDF]
Nature Immunology, 2009 Factor H (FH) is an abundant regulator of complement activation and protects host cells from self-attack by complement. Here we provide insight into the regulatory activity of FH by solving the crystal structure of the first four domains of FH in complex with its target, complement fragment C3b.
Piet Gros +5 more
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Restoration by purified C3b inactivator of complement-mediated function in vivo in a patient with C3b inactivator deficiency. [PDF]
Journal of Clinical Investigation, 1975 In a patient with lifelong increased susceptibility to infection and multiple abnormalities in complement-mediated functions, the infusion of normal plasma had been seen to produce a prolonged partial correction of serum abnormalities. It was subsequently shown that the patient was genetically deficient in the C3b inactivator and that immunochemical ...
R S Rosen +4 more
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Properdin binding to complement activating surfaces depends on initial C3b deposition [PDF]
Proceedings of the National Academy of Sciences, 2017 SignificanceThe role of properdin in stabilization of the alternative pathway C3 convertase is indisputable, whereas its role as pattern recognition molecule remains controversial. Properdin lacks the structural homology shared by other pattern recognition molecules of the complement system, and has its major function in stabilizing the C3bBb ...
Tom Eirik Mollnes +13 more
openaire +6 more sources
Ionic tethering contributes to the conformational stability and function of complement C3b
Molecular Immunology, 2017 C3b, the central component of the alternative pathway (AP) of the complement system, coexists as a mixture of conformations in solution. These conformational changes can affect interactions with other proteins and complement regulators. Here we combine a computational model for electrostatic interactions within C3b with molecular imaging to study the ...
Andrés López-Perrote +6 more
openaire +3 more sources
Complement C3b receptors on erythrocytes in patients with juvenile rheumatoid arthritis [PDF]
Arthritis & Rheumatism, 1987 AbstractForty patients with juvenile rheumatoid arthritis (JRA) were examined for C3b receptor (CR1) levels on erythrocytes (by an enzyme‐linked immunosorbent assay), levels of circulating immune complexes (IC) (by a polyethylene glycol precipitation–complement consumption method), C3d split products (by intermediate gel rocket immunoelectrophoresis ...
Thomsen, Bjarne S. +7 more
openaire +4 more sources
Interaction of uromodulin and complement factor H enhances C3b inactivation [PDF]
Journal of Cellular and Molecular Medicine, 2016 AbstractRecent studies suggest that uromodulin plays an important role in chronic kidney diseases. It can interact with several complement components, various cytokines and immune system cells. Complement factor H (CFH), as a regulator of the complement alternative pathway, is also associated with various renal diseases.
Fengmei Wang +6 more
openaire +3 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Although attractive for relevance to real‐world scenarios, real‐world data (RWD) is typically used for drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in neurological diseases such as the rare disease, amyotrophic lateral sclerosis (ALS), which has no disease‐modifying treatments ...
Mohammadali Alidoost +9 more
wiley +1 more source
Crystallization of human complement component C3b in the presence of a staphylococcal complement-inhibitor protein (SCIN) [PDF]
Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2009 Staphylococcus aureus secretes a number of small proteins that effectively attenuate the human innate immune response. Among these, the staphylococcal complement-inhibitor protein (SCIN) disrupts the function of the complement component 3 (C3) convertase that is initiated through either the classical or the alternative pathway and thereby prevents ...
John D. Lambris +6 more
openaire +3 more sources
ESC Heart Failure, EarlyView.Abstract Aims Right ventricular (RV) remodelling, a progressive condition characterized by maladaptive cardiac structural and functional changes, primarily results from prolonged pressure overload in patients with pulmonary hypertension (PH). Accurate, universal and easy‐to‐use biomarkers for assessing the severity of RV remodelling are lacking.
Xuenan Wang +5 more
wiley +1 more source