Results 11 to 20 of about 14,253 (157)

Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions. [PDF]

PLoS ONE, 2016
Complement factor H-related protein 1 (CFHR1) is a complement regulator which has been reported to regulate complement by blocking C5 convertase activity and interfering with C5b surface association. CFHR1 also competes with complement factor H (CFH) for
Jonathan P Hannan, Jennifer Laskowski, Joshua M Thurman, Gregory S Hageman, V Michael Holers   +4 more
doaj   +1 more source

Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity

Frontiers in Immunology, 2022
The complement system is a part of the innate immune system, where it labels intruding pathogens as well as dying host cells for clearance. If complement regulation is compromised, the system may contribute to pathogenesis.
Henrik Pedersen, Rasmus Kjeldsen Jensen, Annette Gudmann Hansen, Steen Vang Petersen, Steffen Thiel, Nick Stub Laursen, Nick Stub Laursen, Gregers Rom Andersen   +7 more
doaj   +1 more source

Discovery of APL-1030, a Novel, High-Affinity Nanofitin Inhibitor of C3-Mediated Complement Activation

Biomolecules, 2022
Uncontrolled complement activation contributes to multiple immune pathologies. Although synthetic compstatin derivatives targeting C3 and C3b are robust inhibitors of complement activation, their physicochemical and molecular properties may limit access ...
Joshua Garlich, Mathieu Cinier, Anne Chevrel, Anaëlle Perrocheau, David J. Eyerman, Mark Orme, Olivier Kitten, Lukas Scheibler   +7 more
doaj   +1 more source

Complement Activation Profile in Myasthenia Gravis Patients: Perspectives for Tailoring Anti-Complement Therapy

Biomedicines, 2022
The complement system plays a key role in myasthenia gravis (MG). Anti-complement drugs are emerging as effective therapies to treat anti-acetylcholine receptor (AChR) antibody-positive MG patients, though their usage is still limited by the high costs ...
Nicola Iacomino, Fiammetta Vanoli, Rita Frangiamore, Marta Ballardini, Letizia Scandiffio, Federica Bortone, Francesca Andreetta, Fulvio Baggi, Pia Bernasconi, Carlo Antozzi, Paola Cavalcante, Renato Mantegazza   +11 more
doaj   +1 more source

Staphylococcal protein Ecb impairs complement receptor-1 mediated recognition of opsonized bacteria. [PDF]

PLoS ONE, 2017
Staphyloccus aureus is a major human pathogen leading frequently to sepsis and soft tissue infections with abscesses. Multiple virulence factors including several immune modulating molecules contribute to its survival in the host. When S.
Hanne Amdahl, Karita Haapasalo, Lydia Tan, Taru Meri, Pentti I Kuusela, Jos A van Strijp, Suzan Rooijakkers, T Sakari Jokiranta   +7 more
doaj   +1 more source

Quantitative detection of red blood cell antibody-mediated complement activation

Zhongguo shuxue zazhi, 2022
Objective To construct an in-vitro model of erythrocyte antibody-mediated complement activation, and establish quantitative detection methods based on flow cytometry and spectrophotometry, so as to explore the correlation of anti-body titers and ...
Zhongying WANG, Jian LI, Fengyong ZHAO, Chenrui QIAN, Wei SHEN, Liangfeng FAN, Sha JIN, Jiewei ZHENG, Yuyu ZHANG, Dong XIANG   +9 more
doaj   +1 more source

Human Tamm-Horsfall protein, a renal specific protein, serves as a cofactor in complement 3b degradation. [PDF]

PLoS ONE, 2017
Tamm-Horsfall protein (THP) is an abundant urinary protein of renal origin. We hypothesize that THP can act as an inhibitor of complement since THP binds complement 1q (C1q) of the classical complement pathway, inhibits activation of this pathway, and is
Diana C J Rhodes
doaj   +1 more source

Insights Into the Structure-Function Relationships of Dimeric C3d Fragments

Frontiers in Immunology, 2021
Cleavage of C3 to C3a and C3b plays a central role in the generation of complement-mediated defences. Although the thioester-mediated surface deposition of C3b has been well-studied, fluid phase dimers of C3 fragments remain largely unexplored.
Ayla A. Wahid, Rhys W. Dunphy, Alex Macpherson, Alex Macpherson, Beth G. Gibson, Liudmila Kulik, Kevin Whale, Catherine Back, Thomas M. Hallam, Bayan Alkhawaja, Rebecca L. Martin, Ingrid Meschede, Maisem Laabei, Alastair D. G. Lawson, V. Michael Holers, Andrew G. Watts, Andrew G. Watts, Susan J. Crennell, Claire L. Harris, Kevin J. Marchbank, Jean M. H. van den Elsen, Jean M. H. van den Elsen   +21 more
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Molecular Simulation Study on the Interaction between Porcine CR1-like and C3b

Molecules, 2023
The molecular basis of porcine red blood cell immune adhesion function stems from the complement receptor type 1-like (CR1-like) on its cell membrane.
Zhen Hou, Wei Yin, Zhili Hao, Kuohai Fan, Na Sun, Panpan Sun, Hongquan Li   +6 more
doaj   +1 more source

Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models

Frontiers in Immunology, 2018
Complement is essential for the protection against infections; however, dysregulation of complement activation can cause onset and progression of numerous inflammatory diseases.
Seline A. Zwarthoff, Evelien T. M. Berends, Sanne Mol, Maartje Ruyken, Piet C. Aerts, Mihály Józsi, Carla J. C. de Haas, Suzan H. M. Rooijakkers, Ronald D. Gorham   +8 more
doaj   +1 more source