Results 21 to 30 of about 792,617 (213)
Human Tamm-Horsfall protein, a renal specific protein, serves as a cofactor in complement 3b degradation. [PDF]
PLoS ONE, 2017 Tamm-Horsfall protein (THP) is an abundant urinary protein of renal origin. We hypothesize that THP can act as an inhibitor of complement since THP binds complement 1q (C1q) of the classical complement pathway, inhibits activation of this pathway, and is
Diana C J Rhodes
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Insights Into the Structure-Function Relationships of Dimeric C3d Fragments
Frontiers in Immunology, 2021 Cleavage of C3 to C3a and C3b plays a central role in the generation of complement-mediated defences. Although the thioester-mediated surface deposition of C3b has been well-studied, fluid phase dimers of C3 fragments remain largely unexplored.
Ayla A. Wahid +21 more
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Molecular Simulation Study on the Interaction between Porcine CR1-like and C3b
Molecules, 2023 The molecular basis of porcine red blood cell immune adhesion function stems from the complement receptor type 1-like (CR1-like) on its cell membrane.
Zhen Hou +6 more
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Disulfide bridges in human complement component C3b
FEBS Letters, 1993 The disulfide bridges of human complement component C3b, derived from C3 by removal of the 77‐residue C3a, have been determined. The 10 bridges are Cys537‐Cys794, Cys605‐Cys640, Cys851‐Cys1491, Cys1079‐Cys1169, Cys1336‐Cys1467, Cys1367‐Cys1436, Cys1448‐Cys1489, Cys1496‐Cys1568, Cys1515‐Cys1639, and Cys1615‐Cys1624.
Dolmer, Klavs, Sottrup-Jensen, Lars
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Frontiers in Immunology, 2018 Complement is essential for the protection against infections; however, dysregulation of complement activation can cause onset and progression of numerous inflammatory diseases.
Seline A. Zwarthoff +8 more
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Strain Specific Variations in Acinetobacter baumannii Complement Sensitivity
Frontiers in Immunology, 2022 The complement system is required for innate immunity against Acinetobacter baumannii, an important cause of antibiotic resistant systemic infections. A.
Gathoni Kamuyu +12 more
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Effect of complement-protein-C3b density on the binding of complement factor H to surface-bound C3b [PDF]
Biochemical Journal, 1991 Various amounts of the activation fragment C3b of the complement (C) protein C3 were coupled to Sepharose 4B by catalysis with the C3 convertase of the alternative pathway of C. The binding of radioactively labelled C proteins B and H (= factor H) to the C3b-carrying particles was assayed. It was found that the relative binding of H, but not of B, fell
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Structure of C3b reveals conformational changes that underlie complement activity [PDF]
Nature, 2006 Resistance to infection and clearance of cell debris in mammals depend on the activation of the complement system, which is an important component of innate and adaptive immunity. Central to the complement system is the activated form of C3, called C3b, which attaches covalently to target surfaces to amplify complement response, label cells for ...
Janssen, B.J.C. +4 more
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Journal of Experimental Medicine, 1977 The complement regulatory enzyme, C3b inactivator (C3bINA), has been purified from human serum by affinity chromatography on an anti-C3bINA Sepharose column.
M. K. Pangburn +2 more
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Toxins, 2020 Enterohemorrhagic Escherichia coli (EHEC) infections can cause EHEC-associated hemolytic uremic syndrome (eHUS) via its main virulent factor, Shiga toxins (Stxs). Complement has been reported to be involved in the progression of eHUS.
Sára Kellnerová +10 more
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