Results 31 to 40 of about 12,786 (117)

A Revised Mechanism for the Activation of Complement C3 to C3b [PDF]

Journal of Biological Chemistry, 2015
The solution structure of complement C3b is crucial for the understanding of complement activation and regulation. C3b is generated by the removal of C3a from C3. Hydrolysis of the C3 thioester produces C3u, an analog of C3b. C3b cleavage results in C3c and C3d (thioester-containing domain; TED).
Rodriguez, E, Nan, R, Li, K, Gor, J, Perkins, SJ   +4 more
openaire   +5 more sources

Real‐world evidence of pegcetacoplan in patients with paroxysmal nocturnal haemoglobinuria: A nationwide Italian study

British Journal of Haematology, Volume 206, Issue 4, Page 1246-1249, April 2025.
In this study, we collected real‐world evidence on the use of pegcetacoplan among 22 Italian patients with paroxysmal nocturnal haemoglobinuria showing suboptimal response to anti‐C5 treatments eculizumab and ravulizumab. Most patients exhibited a complete or good response as per the criteria of the European Bone Marrow Transplant group (Risitano et al.
Elisabetta Metafuni, Filippo Achille Brioschi, Andrea Patriarca, Claudia Leoni, Giorgia Battipaglia, Daniela Carlino, Annalisa Condorelli, Valeria Di Giacomo, Sarah Marktel, Maria Antonietta Marzilli, Maurizio Miglino, Esther Natalie Oliva, Antonella Sau, Alessandra Ricco, Grazia Sanpaolo, Annarita Trolese, Anna Paola Iori, Simona Sica, Wilma Barcellini, Bruno Fattizzo   +19 more
wiley   +1 more source

Binding of fluid-phase complement components C3 and C3b to human lymphocytes [PDF]

Biochemical Journal, 1981
It is known that a population of B-lymphocytes has receptors for the third component of complement, C3, and that these lymphocytes may be identified by their ability to form rosettes with sheep erythrocytes coated with covalently bound fragments of complement component C3.
Robert B. Sim, E Sim
openaire   +3 more sources

Neuropathological and cerebrospinal fluid correlates of choroid plexus inflammation in progressive multiple sclerosis

Brain Pathology, EarlyView.
Graphical representation of the widespread white matter (blue color mask) and grey matter (cortical and deep grey matter; red color mask) demyelination in MS cases characterized by substantial inflammation of the CP (A). The presence of lesions was mainly associated with periventricular white matter and hippocampus areas (A).
R. Magliozzi, S. Hametner, M. Mastantuono, A. Mensi, M. Karimian, L. Griffiths, L. M. Watkins, A. Poli, G. M. Berti, E. Barusolo, B. Bellini, S. Rossi, D. Gveric, J. A. Stratton, K. Akassoglou, S. Magon, R. Nicholas, R. Reynolds, O. W. Howell, S. Monaco   +19 more
wiley   +1 more source

Complement Receptor Subtypes C3b and C3d in Lymphatic Tissue and Follicular Lymphoma [PDF]

British Journal of Cancer, 1978
To substantiate the origin of follicular (nodular) lymphoma cells from germinal-centre cells, the lymphoma cells from 7 patients with follicular lymphoma and from 9 tonsils and 2 lymph nodes were studied for the presence and distribution of complement-receptor subtypes (i.e., the receptors for C3b and C3d).
U Siemssen, K Lennert, H Stein
openaire   +2 more sources

Complement dysregulation in human tauopathies

Brain Pathology, EarlyView.
Complement protein and activation product levels were assessed in post‐mortem frontal cortex from three distinct subtypes of Tauopathy: Corticobasal degeneration, globular glial tauopathy, and Pick's disease. Quantification of complement proteins by immunohistochemistry and ELISA showed elevation of key complement proteins (C1q) regulators (FI) and ...
Jacqui Nimmo, Samuel Keat, Louis De Muynck, B. Paul Morgan   +3 more
wiley   +1 more source

Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and high‐throughput RNA sequencing

British Journal of Pharmacology, EarlyView.
Background and Purpose Nimodipine, an L‐type voltage‐gated calcium channel blocker, is an approved cerebral vasorelaxant. We hypothesized that nimodipine attenuates the pro‐inflammatory shift in microglial phenotypes. Here, we analysed the effects of nimodipine on morphological and functional microglial phenotypes as well as their transcriptomic ...
István Pesti, Valentin Varga, Erda Qorri, Rita Frank, Diana Kata, Krisztián Vinga, Péter Archibald Szarvas, Ákos Menyhárt, Károly Gulya, Ferenc Bari, Eszter Farkas   +10 more
wiley   +1 more source

The formation and cross‐border connectivity of bank branch networks across the Canadian provinces: regional internationalization via interbank networks and foreign trade (1879–1900)

The Economic History Review, EarlyView.
Abstract This study advances a new approach to investigating the resilience of regional banking systems by reconstructing the co‐evolving branch and interbank networks in post‐Confederation Canada (1879–1900). By digitizing annual banking registers, this study employed a microgeographic approach to constructing a novel longitudinal dataset on city ...
Alena V. Pivavarava
wiley   +1 more source

Anchored Indirect Treatment Comparison Finds Comparable Effects of Pegcetacoplan and Iptacopan in Paroxysmal Nocturnal Haemoglobinuria

European Journal of Haematology, EarlyView.
ABSTRACT Background Paroxysmal nocturnal haemoglobinuria (PNH) is an ultra‐rare, acquired non‐malignant haematological disorder characterised by thrombosis risk, serious complications and debilitating symptoms in untreated patients. Objective This anchored indirect treatment comparison (ITC) evaluated efficacy data between proximal complement 3 ...
Regis Peffault de Latour, Austin Kulasekararaj, David Dingli, Koo Wilson, Piotr Wojciechowski, Zalmai Hakimi, Jameel Nazir, Barbara Czech, Peter Hillmen, Jeff Szer   +9 more
wiley   +1 more source

Approach to autologous stem cell transplantation in a patient with severe cold agglutinin disease, a case report

Transfusion, Volume 65, Issue 3, Page 637-642, March 2025.
Abstract Background Cold agglutinin disease (CAD) or syndrome (CAS) can be particularly challenging when autologous stem cell transplant (ASCT) is needed. Standard peripheral blood stem cell (PBSC) collection and manipulation involve ex vivo blood manipulations at lower than body temperature, predisposing to agglutination during graft collection ...
Mathias Castonguay, Léa Bernard, Marylène Corriveau, Anik Castonguay, Geneviève Quenneville, Sandra Cohen, Sylvie Lachance, Imran Ahmad, Isabelle Cournoyer, Thomas Kiss, Isabelle Fleury, Luigina Mollica, Denis‐Claude Roy, Jean Roy, Guy Sauvageau, Olivier Veilleux, Martin Giroux, Jean‐Sébastien Delisle, Mélissa Boileau   +18 more
wiley   +1 more source