Results 31 to 40 of about 792,617 (213)
Identification of C3b-Binding Small-Molecule Complement Inhibitors Using Cheminformatics [PDF]
The Journal of Immunology, 2017 Abstract The complement system is an elegantly regulated biochemical cascade formed by the collective molecular recognition properties and proteolytic activities of more than two dozen membrane-bound or serum proteins. Complement plays diverse roles in human physiology, such as acting as a sentry against invading microorganisms, priming ...
Brandon L Garcia +6 more
openaire +2 more sources
Zinc-induced Self-association of Complement C3b and Factor H
Journal of Biological Chemistry, 2013 Background: Sub-retinal pigment epithelial deposits contain complement proteins and bioavailable zinc. Results: Ultracentrifugation and x-ray scattering show that >100 μm zinc induces oligomer formation in each of C3, C3u, and C3b, in analogy to Factor H.
R. Nan +6 more
semanticscholar +1 more source
Autoantibodies Against C3b—Functional Consequences and Disease Relevance
Frontiers in Immunology, 2019 The complement component C3 is at the heart of the complement cascade. It is a complex protein, which generates different functional activated fragments (C3a, C3b, iC3b, C3c, C3d).
Vasil V. Vasilev +13 more
doaj +1 more source
Journal of Biological Chemistry, 1986 The human complement C3b/C4b receptor (CR1), a single chain membrane glycoprotein of Mr approximately 200,000, has several cell-specific Mr variations as well as an allelic variation involving four phenotypes whose Mr values span a range of 90,000.
D. Lublin, R. Griffith, J. Atkinson
semanticscholar +1 more source
The role of salivary and intestinal complement system inhibitors in the midgut protection of triatomines and mosquitoes. [PDF]
PLoS ONE, 2009 Saliva of haematophagous arthropods contain biomolecules involved directly or indirectly with the haematophagy process, and among them are encountered some complement system inhibitors.
Veruska Cavalcanti Barros +7 more
doaj +1 more source
Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b.
PLoS ONE, 2012 Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Tina K Koch +7 more
doaj +1 more source
Journal of Experimental Medicine, 1978 Native rat mast cell macromolecular heparin proteoglycan and commercial hog heparin glycosaminoglycan chains inhibit generation of the amplification convertase, C3b, Bb. The inhibitory action of heparin is not due to chelation of magnesium.
B. J. M. Weiler +4 more
semanticscholar +1 more source
Journal of Experimental Medicine, 1975 The fixation of the third component of complement (C3) results in many important biological phenomenon, among which are (a) immune adherence (1), (b) enhancement of phagocytosis (2,3), (c) the release of an anaphylatoxin which is a potent releaser of ...
J. Gitlin, F. Rosen, P. Lachmann
semanticscholar +1 more source
Characterization of Binding Properties of Individual Functional Sites of Human Complement Factor H
Frontiers in Immunology, 2020 Factor H exists as a 155,000 dalton, extended protein composed of twenty small domains which is flexible enough that it folds back on itself. Factor H regulates complement activation through its interactions with C3b and polyanions.
Aftabul Haque +7 more
doaj +1 more source
Frontiers in Immunology, 2022 Antibodies specific for the spike glycoprotein (S) and nucleocapsid (N) SARS-CoV-2 proteins are typically present during severe COVID-19, and induced to S after vaccination.
Rachel E. Lamerton +20 more
doaj +1 more source