Results 131 to 140 of about 11,452 (258)

CD59, Disulphide-Locked Human C9 and Horse C9 Inhibit Human Membrane Attack Complex Assembly by Similar Mechanisms. [PDF]

Immunology
Cooke RS, Spicer BA, Harrison RA, Dunstone MA, Morgan BP, Zelek WM.   +5 more
europepmc   +1 more source

Fluorescence Properties and Mg2+ Selectivity of Aryl‐Alkynyl Derivatives of the o‐Aminophenoltriacetate (APTRA) Ligand

Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.
It is a challenge to improve the selectivity of high‐denticity ligands for Mg2+ over Ca2+. We show that in aryl‐alkynyl derivatives of APTRA, electron‐withdrawing substituents lower the binding affinity for Ca2+ more than Mg2+, making the ligand more selective for Mg2+.
Laura L. Duncan, Christopher Hogg, J. A. Gareth Williams   +2 more
wiley   +1 more source

Complement proteins associated with circulatory and glomerular IgA-containing immune complexes in patients with IgA nephropathy. [PDF]

Sci Rep
Tsuji Y, Ohyama Y, Saitoh S, Enomoto T, Hirayama M, Yamaguchi H, Nishioka T, Mizuno T, Tsuboi N, Novak J, Takahashi K.   +10 more
europepmc   +1 more source

Crystal Engineering of Reticular Materials for Gas‐ and Liquid‐Phase Hydrocarbon Separation

Advanced Materials, Volume 38, Issue 16, 17 March 2026.
Crystal engineering enables systematic study of structure/function relationships as exemplified by pore engineering of reticular sorbents, including porous coordination networks and covalent organic frameworks. This review assesses such studies applied across the full scope of industrially relevant hydrocarbon separations to provide insight into how ...
Xia Li, Soumya Mukherjee, Michael J. Zaworotko   +2 more
wiley   +1 more source

Spatial heterogeneity in microglia-complement crosstalk: Implications for synaptic pruning in Alzheimer's disease. [PDF]

Alzheimers Dement
Ye Q, Gao W, Feng J, Li X, Li J, Yang F, Li L, Zi M, Wu X, Gao H, Li H.   +10 more
europepmc   +1 more source

Organic and Metallacages for Chemical Sensing: Progress in Water‐Compatible Systems

Advanced Sensor Research, Volume 5, Issue 3, March 2026.
Supramolecular cages function as three‐dimensional receptors for selective molecular recognition and sensing, and this review outlines design principles for water‐stable architectures, key analyte‐ and medium‐dependent challenges, recent water‐compatible examples (including polymer‐integrated systems), and future opportunities for cage‐based ...
Rabia Zahid, Martina Viola, Maria Vittoria Balli, Guillermo Moreno‐Alcántar, Pierre Picchetti   +4 more
wiley   +1 more source

Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu, Le Xie, Yuan Jin, Sen Chen, Xinyu Shi, Yanjun Zong, Zhengdong Zhao, Wei‐Jia Kong, Yu Sun   +8 more
wiley   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

Measuring the molecular origins of stiffness in organic semiconductors. [PDF]

Nat Commun
Hwang KH, Brandt D, Cristofaro S, Nickerson CJ, Modesti F, Gicevičius M, Cervantes MTR, Volpi M, Spalek LJ, Muccioli L, Claesson PM, Fruk L, Geerts Y, Schweicher G, Olivier Y, Johnson ER, Venkateshvaran D.   +16 more
europepmc   +1 more source

Chromones as Nonclassical Inhibitors of Carbonic Anhydrase IX and XII Isoforms: Probing Chromone‐Based Derivatives

Archiv der Pharmazie, Volume 359, Issue 3, March 2026.
Chromone‐based derivatives were synthesized and evaluated for selective inhibition of tumor‐associated carbonic anhydrases IX and XII. Structure–activity relationships, docking studies, and ADMET profiling revealed promising candidates with selective tumoral isoform inhibition, supporting their potential as anticancer leads. ABSTRACT A small library of
Lisa Sequeira, Simona Distinto, Carlos Fernandes, Erica Sanna, Rita Meleddu, Marco Gaspari, Filippo Cottiglia, Alessia Onali, Andrea Angeli, Fernanda Borges, Eugenio Uriarte, Stefano Alcaro, Claudiu T. Supuran, Elias Maccioni   +13 more
wiley   +1 more source