Results 211 to 220 of about 11,452 (258)

Human complement protein C8 gamma.

Biochimica et biophysica acta, 2000
Human C8 gamma is a 22 kDa subunit of complement component C8, which is one of five components (C5b, C6, C7, C8, C9) that interact to form the cytolytic membrane attack complex (MAC) of complement. C8 contains three nonidentical subunits (alpha, beta, gamma) that are products of different genes.
S F, Schreck, C, Parker, M E, Plumb, J M, Sodetz   +3 more
openaire   +1 more source

Inhibition of the Eighth Component of Complement (C8) by Ethylenediaminetetra-Acetate (Edta)

The Journal of Immunology, 1970
Abstract Functionally pure C8 from human or guinea pig serum was inactivated by 1 to 2 × 10-3 M EDTA. Native C8 in serum was partially inactivated by EDTA, but much longer periods of incubation at 37°C were required for this to be evident.
D R, Schultz, R M, Zarco
openaire   +2 more sources

The gamma subunit of the eighth complement component (C8) in rainbow trout

Developmental & Comparative Immunology, 2006
Of the 35 proteins, enzymes, receptors and regulatory components of the complement system, C8gamma is unique in that it is the only lipocalin. C8gamma is a subunit of the C8 molecule, which is one of the five components (C5b, C6, C7, C8 and C9) that interact as a consequence of complement activation to form the membrane attack complex.
Anastasios D, Papanastasiou, Ioannis K, Zarkadis   +1 more
openaire   +2 more sources

Genetic Polymorphisms and Linkage Relations of Complement Factor C8

1985
Abstract Genetically determined variation in both the C8α-chain (C81) and β-chain (C82) is detected by isoelectric focusing and imnunoblotting, supplemented by two dimensional electrophoresis. The C81 and C82 loci are closely linked. Both C8 loci are linked to the chromosome 1 marker loci PGM1 and Rh .
S. ROGDE, B. OLAISEN, B. MEVÅG, P. TEISBERG, T. GEDDE-DAHL   +4 more
openaire   +1 more source

Human complement C81 (C8 A) polymorphism: detection and segregation of new variants

Human Genetics, 1993
In addition to the earlier detected C81(A) rare variants A1, A2 (now A3) and B1 (now B2), six new rare variants (C81 A2 new, A4, A5, A6, M1 and B1new) are described within the polymorphism of the eighth component of human complement (alpha-gamma chain subunit). Except for A3, all rare C81 A variants are only detected by isoelectric focusing, and not by
C, Rittner, B, Stradmann-Bellinghausen
openaire   +2 more sources

In vitro expression of the beta subunit of human complement component C8

Molecular Immunology, 1996
Human C8 is one of five components of the cytolytic C5b-9 complex of complement. It is an oligomeric protein composed of three subunits (alpha, beta, gamma) encoded in separate genes. These are arranged as a disulfide-linked alpha-gamma dimer and a noncovalently associated beta chain.
C S, Letson, K M, Kaufman, J M, Sodetz
openaire   +2 more sources

Lymphocyte‐Associated Complement: Role of C8 in Certain Cell‐mediated Lytic Reactions

Scandinavian Journal of Immunology, 1974
51Cr‐ labelled chicken erythrocytes (E) were treated with human and C7 to form , susceptible to lysis by the terminal complement components C8 and C9 ('reactive lysis') Addition of purified and extensively washed human blood lymphocytes, but not of erythrocytes, to resulted in a similar but cell‐mediated reactive lysis. Contamination of the effector
P, Perlmann, H, Perlmann, P, Lachmann
openaire   +2 more sources

Homologous restriction factor: Effect on complement C8 and C9 uptake and lysis

Molecular Immunology, 1994
Homologous restriction factor (HRF) is a complementary regulatory protein found on the surface of human erythrocytes and other cell types. It has the function of blocking the lytic action of the membrane attack complex (MAC) of complement when incorporated into a membrane.
L S, Zalman, H, Müller-Eberhard
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Complement component deficiencies and infection: C5, C8 and C3 deficiencies in three families

European Journal of Pediatrics, 1992
Three families are described with complement component deficiencies. In one family, five children had C5 deficiency; in a second family, two children had C8 deficiency and one child in a third family had C3 deficiency. The index cases were identified during screening of patients with recurrent pyogenic infections, recurrent meningitis and ...
O, Sanal, M, Loos, F, Ersoy, G, Kanra, G, Seçmeer, I, Tezcan   +5 more
openaire   +2 more sources

Restriction of Complement-Mediated Membrane Damage by the Eighth Component of Complement: A Dual Role for C8 in the Complement Attack Sequence

The Journal of Immunology, 1979
Abstract Inhibitors of the fluid phase complex were examined in serum from which the lipoproteins had been removed. A limited number of these nonlipoprotein inhibitors were observed, and one was shown to be C8 by several criteria.
G R, Nemerow, K I, Yamamoto, T F, Lint
openaire   +2 more sources