Results 31 to 40 of about 11,452 (258)

Proteomic Analysis of Humoral Immune Components in Bronchoalveolar Lavage of Patients Infected or Colonized by Aspergillus fumigatus

Frontiers in Immunology, 2021
Humoral immune components have been individually studied in the context of interaction of host with Aspergillus fumigatus, a major airborne fungal pathogen. However, a global view of the multitude and complex nature of humoral immune components is needed
Sarah Dellière, Sarah Dellière, Sarah Dellière, Magalie Duchateau, Sarah Sze Wah Wong, Quentin Giai Gianetto, Quentin Giai Gianetto, Hélène Guegan, Mariette Matondo, Jean-Pierre Gangneux, Vishukumar Aimanianda   +10 more
doaj   +1 more source

Complement Dysregulation in Obese Versus Nonobese Polycystic Ovary Syndrome Patients

Cells, 2023
Introduction: Upregulation of complement system factors are reported to be increased in polycystic ovary syndrome (PCOS) and may be due to obesity and insulin resistance rather than inherently due to PCOS.
Alexandra E. Butler, Abu Saleh Md Moin, Thozhukat Sathyapalan, Stephen L. Atkin   +3 more
doaj   +1 more source

Different Metabolomic and Proteomic Profiles of Cerebrospinal Fluid in Ventricular and Lumbar Compartments in Relation to Leptomeningeal Metastases

Metabolites, 2022
The different molecular profiles of cerebrospinal fluid (CSF) between ventricular and lumbar compartments remain elusive, especially in the context of leptomeningeal metastasis (LM), which affects CSF flow.
Ji-Woong Kwon, Ji Hye Im, Kyue-Yim Lee, Byong Chul Yoo, Jun Hwa Lee, Kyung-Hee Kim, Jong Heon Kim, Sang Hoon Shin, Heon Yoo, Ho-Shin Gwak   +9 more
doaj   +1 more source

THE EIGHTH COMPONENT OF HUMAN COMPLEMENT (C8): ISOLATION, CHARACTERIZATION, AND HEMOLYTIC EFFICIENCY [PDF]

The Journal of Experimental Medicine, 1969
A method was described allowing the isolation of the eighth component of complement, C8, from human serum. C8 is an immunochemically definable, heretofore unrecognized serum protein with a molecular weight of approximately 150,000 and an electrophoretic mobility of a γ1-globulin.
J A, Manni, H J, Müller-Eberhard
openaire   +2 more sources

Biosynthetic homeostasis and resilience of the complement system in health and infectious diseaseResearch in context

EBioMedicine, 2019
Background: The complement system is a central component of the innate immune system. Constitutive biosynthesis of complement proteins is essential for homeostasis.
Esther Willems, Wynand Alkema, Jenneke Keizer-Garritsen, Anouk Suppers, Michiel van der Flier, Ria H.L.A. Philipsen, Lambert P. van den Heuvel, Elena Volokhina, Renate G. van der Molen, Jethro A. Herberg, Michael Levin, Victoria J. Wright, Inge M.L. Ahout, Gerben Ferwerda, Marieke Emonts, Navin P. Boeddha, Irene Rivero-Calle, Federico Martinon Torres, Hans J.C.T. Wessels, Ronald de Groot, Alain J. van Gool, Jolein Gloerich, Marien I. de Jonge   +22 more
doaj   +1 more source

Regiodivergent C3 and C4 Amination of Quinolines via Radical and Ionic Pathways

Angewandte Chemie, EarlyView.
A regiodivergent strategy converts a single N‐aminoquinolinium precursor into either C3‐ or C4‐aminated quinolines. Nucleophile‐induced dearomatization diverges into light‐driven N‐centered radical capture (C3) or base‐promoted SNAr (C4), enabling rapid assembly of aminoquinoline libraries and late‐stage diversification.
Ye‐Eun Kim, Jieun Kim, Juyeon Lee, Sungwoo Hong   +3 more
wiley   +2 more sources

Protein-centric omics analysis reveals circulating complements linked to non-viral liver diseases as potential therapeutic targets [PDF]

Clinical and Molecular Hepatology
Background/Aims To evaluate the causal correlation between complement components and non-viral liver diseases and their potential use as druggable targets.
Yingzhou Shi, Hang Dong, Shiwei Sun, Xiaoqin Wu, Jiansong Fang, Jianbo Zhao, Junming Han, Zongyue Li, Huixiao Wu, Luna Liu, Wanhong Wu, Yang Tian, Guandou Yuan, Xiude Fan, Chao Xu   +14 more
doaj   +1 more source

Near‐Infrared‐Light‐Driven Photochemistry and Photocatalysis: Mechanisms, Recent Applications, and Opportunities in Organic Synthesis and Biology

Angewandte Chemie, EarlyView.
This minireview highlights recent advances in catalyst development and mechanistic strategies that enable photochemical and photocatalytic reactivity under 700–1000 nm NIR light, emphasizing how long‐wavelength excitation expands opportunities in both synthetic chemistry and biology.
Santosh K. Pagire, Wesley J. Olivier, Debabrata Maiti, Alex C. Bissember   +3 more
wiley   +2 more sources

Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells

Advanced Science, EarlyView.
Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li, Hang Zheng, Yuxing Lin, Ziwei Zhao, Yijia Mai, Zhangrong Lou, Qiang Liu, Zhao Ma, Chengjun Wu   +8 more
wiley   +1 more source

A Glucose‐Responsive Intelligent Antibacterial and Oxygen‐Producing Hydrogel Promotes the Healing of Diabetic Wounds by Regulating Cellular Heterogeneity

Advanced Science, EarlyView.
We have developed a glucose‐triggered on‐demand drug delivery CF‐CPGaMPN hydrogel based on borate ester bonds. It inactivates microbes, releases oxygen, and enables on‐demand drug release in high‐glucose environments to promote healing of diabetic wounds. Single‐cell sequencing reveals that the CF‐CPGaMPN hydrogel significantly alleviates dysfunctional
Manxuan Liu, Zhongcheng Li, Qian Ren, Ziqian Lu, Yubing Zhang, Yili Guo, Ruomeng Li, Die Hu, Linglin Zhang   +8 more
wiley   +1 more source