Results 51 to 60 of about 11,452 (258)

RT‐DETR‐DA for Complex Scenes: Distracted Driving Detection With Feature Interaction and Dynamic Perception

Advanced Intelligent Systems, EarlyView.
This work proposes RT‐DETR‐DA, an enhanced real‐time detection framework for identifying distracted driving in complex, real‐world environments. The model introduces a dynamic sparse gating multiscale attention module and an attention‐guided dual‐path fusion module to strengthen multiscale perception and cross‐layer feature interaction.
Yi Liu, QiaoXing Li, XiBin Wang, Ying He, Sen Zhang   +4 more
wiley   +1 more source

Pathogenic Leptospira Secreted Proteases Target the Membrane Attack Complex: A Potential Role for Thermolysin in Complement Inhibition

Frontiers in Microbiology, 2017
Leptospirosis is a zoonosis caused by spirochetes from the genus Leptospira. This disease is common in tropical and subtropical areas, constituting a serious public health problem.
Thais A. Amamura, Tatiana R. Fraga, Sílvio A. Vasconcellos, Angela S. Barbosa, Lourdes Isaac   +4 more
doaj   +1 more source

Conditioning Electrical Stimulation for Patients with Moderate or Severe Carpal Tunnel Syndrome: Double Blinded Randomized Controlled Trial

Annals of Neurology, EarlyView.
Objective Carpal tunnel syndrome (CTS) can drastically impair one's ability to work and interferes with activities of daily living. We recently demonstrated that, in rodents, conditioning electrical stimulation (CES) delivered to the nerve 7 days prior to surgery imparts a conditioning lesion‐like effect by accelerating the rate of regeneration along ...
Yusuke Osaki, Jaret L. Olson, Michael J. Morhart, Matthew W. Curran, Douglas W. Zochodne, K. Ming Chan, on behalf of the Central and Northern Alberta Peripheral Nerve Injury Research Consortium, Hollie Power, Adil Ladak, Lindsay Hubenig, Alto Lo, Christine Webber, Karyne Rabey, Andrew Jack, Joe Watt, Mithun Rajshekar, Ellen Lee, Glyn Murgatroyd, Dan Yeung, Kathleen O'Grady   +19 more
wiley   +1 more source

The homology of complement factor C8 gamma chain and alpha-1-microglobulin

Biochemical and Biophysical Research Communications, 1987
The sequence of the complement factor C8 gamma chain shares a remarkable degree of similarity with that of alpha-1-microglobulin, a member of the alpha-2u-globulin superfamily. This superfamily comprises a diverse group of distantly related animal proteins possessing characteristic structural features and similar functions.
L T, Hunt, A, Elzanowski, W C, Barker
openaire   +2 more sources

Complement classical and alternative pathway activation contributes to diabetic kidney disease progression: a glomerular proteomics on kidney biopsies

Scientific Reports
Increasing evidence points toward an essential role for complement activation in the pathogenesis of diabetic kidney disease (DKD). However, the precise molecular mechanisms remain unclear, and the pathway predominantly contributing to complement ...
Yang Yang, Ying Zhang, Yuan Li, Xinjin Zhou, Kazuho Honda, Dedong Kang, Muxi Wang, Jing-Hua Yang, Zongping Xia, Yuan Wei, Lu Liu, Ruimin Hu, Takashi Takaki, Guolan Xing   +13 more
doaj   +1 more source

Genetic polymorphism in C8 beta-chains. Evidence for two unlinked genetic loci for the eighth component of human complement (C8). [PDF]

Journal of Clinical Investigation, 1983
Genetic polymorphism in the beta-subunit of the eighth component of human complement, C8, was defined by isoelectric focusing of serum in polyacrylamide gel in the presence of urea and development of specific patterns of hemolysis in an overlay gel containing antibody-sensitized erythrocytes and C8 beta-chain-deficient serum. Bands of hemolysis induced
C A, Alper, D, Marcus, D, Raum, B H, Petersen, T J, Spira   +4 more
openaire   +2 more sources

Protein N-glycosylation aberrations and glycoproteomic network alterations in osteoarthritis and osteoarthritis with type 2 diabetes

Scientific Reports, 2022
Whether the relationship between type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) can be solely attributed to the shared risk factors, such as obesity, remains controversial.
Yi Luo, Ziguang Wu, Song Chen, Huanhuan Luo, Xiaoying Mo, Yao Wang, Jianbang Tang   +6 more
doaj   +1 more source

Structure of Human C8 Protein Provides Mechanistic Insight into Membrane Pore Formation by Complement [PDF]

Journal of Biological Chemistry, 2011
C8 is one of five complement proteins that assemble on bacterial membranes to form the lethal pore-like "membrane attack complex" (MAC) of complement. The MAC consists of one C5b, C6, C7, and C8 and 12-18 molecules of C9. C8 is composed of three genetically distinct subunits, C8α, C8β, and C8γ.
Lovelace, Leslie L., Cooper, Christopher L., Sodetz, James M., Lebioda, Lukasz   +3 more
openaire   +3 more sources

“Hidden” Landscape of Prehistoric Burial Monuments: The Use of Remote Sensing in the Detection of Neolithic Long Barrows in Bohemia (Czech Republic)

Archaeological Prospection, EarlyView.
ABSTRACT Neolithic long barrows are among the earliest monumental structures in Europe, yet in many parts of Central Europe their surface expression has been largely erased by long‐term agricultural activity. This study evaluates the potential of integrated remote sensing approaches for identifying and contextualizing long barrows and associated ...
Petr Krištuf, Tomáš Kroupa, Peter Milo, Jan Havelka, Jan Turek, Martin Gojda   +5 more
wiley   +1 more source

Heterogeneous MAC Initiator and Pore Structures in a Lipid Bilayer by Phase-Plate Cryo-electron Tomography

Cell Reports, 2016
Pore formation in membranes is important for mammalian immune defense against invading bacteria. Induced by complement activation, the membrane attack complex (MAC) forms through sequential binding and membrane insertion of C5b6, C7, C8, and C9.
Thomas H. Sharp, Abraham J. Koster, Piet Gros   +2 more
doaj   +1 more source