Results 21 to 30 of about 221,380 (236)
Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis [PDF]
Kidney Research and Clinical Practice, 2023 Background Alternative complement pathway dysregulation plays a key role in glomerulonephritis (GN) and is associated with C3 deposition. Herein, we examined pathological and clinical differences between cases of primary GN with C3-dominant (C3D-GN) and ...
Jiwon Ryu +14 more
doaj +1 more source
Mannose binding lectin is required for alphavirus-induced arthritis/myositis [PDF]
, 2015 Mosquito-borne alphaviruses such as chikungunya virus and Ross River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis.
Blevins, Lance K. +10 more
core +1 more source
Quantitative Modeling of the Alternative Pathway of the Complement System. [PDF]
PLoS ONE, 2016 The complement system is an integral part of innate immunity that detects and eliminates invading pathogens through a cascade of reactions. The destructive effects of the complement activation on host cells are inhibited through versatile regulators that
Nehemiah Zewde +3 more
doaj +1 more source
Mathematical Modelling of Alternative Pathway of Complement System [PDF]
Bulletin of Mathematical Biology, 2020 AbstractThe complement system (CS) is an integral part of innate immunity and can be activated via three different pathways. The alternative pathway (AP) has a central role in the function of the CS. The AP of complement system is implicated in several human disease pathologies.
Suruchi Bakshi +10 more
openaire +2 more sources
Frontiers in Immunology, 2015 The complement system is a major constituent of the innate immune system. It not only bridges innate and adaptive arms of the immune system but also links the immune system with the coagulation system.
Hany Ibrahim Kenawy +2 more
doaj +1 more source
Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]
, 2013 This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Abdul-Aziz, M +5 more
core +1 more source
Frontiers in Immunology, 2022 ObjectiveThe pathogenesis of thrombotic microangiopathy (TMA) in lupus nephritis (LN) remains complicated. This study aimed to detect the deposition of complement lectin pathway (LP) and alternative pathway (AP) components in renal tissues, then evaluate
Binshan Zhang, Guolan Xing
doaj +1 more source
Complement factor H and the hemolytic uremic syndrome [PDF]
, 2007 Immune recognition is coupled to powerful proinflammatory effector pathways that must be tightly regulated. The ancient alternative pathway of complement activation is one such proinflammatory pathway.
Atkinson, John P, Goodship, Timothy H.J.
core +3 more sources
Alternative complement pathway deregulation is correlated with dengue severity. [PDF]
PLoS ONE, 2009 BACKGROUND:The complement system, a key component that links the innate and adaptive immune responses, has three pathways: the classical, lectin, and alternative pathways. In the present study, we have analyzed the levels of various complement components
Eduardo J M Nascimento +6 more
doaj +1 more source
Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein [PDF]
, 2012 Human complement factor H-related protein (CFHR) 4 belongs to the factor H family of plasma glycoproteins that are composed of short consensus repeat (SCR) domains.
Hebecker, Mario, Józsi, Mihály
core +1 more source