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Complement and complement regulators in the male reproductive system
Molecular Immunology, 2006Spermatozoa are almost unique among cells in that they must survive transplantation into a foreign host in order to perform their physiological role. The biggest hurdle to overcome is innate immune defence that will target the invaders in the female genital tract.
Claire L, Harris +2 more
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The Role of Complement and Complement Receptors in Induction and Regulation of Immunity.
Annual Review of Immunology, 1998▪ Abstract  Covalent attachment of activated complement C3 (C3d) to antigen links innate and adaptive immunity by targeting antigen to follicular dendritic cells (FDC) and B cells via specific receptors CD21 and CD35. Recent characterization of knockout mice deficient in complement components C3, C4, or the receptors CD21 and CD35 as well as ...
Michael C Carroll
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New complement regulator exposed
Blood, 2009The plasma protein CFH is a critical complement regulator with relevance to human diseases. The function of several smaller, CFH-related proteins (CFHRs) has been a mystery. In this issue of Blood, Heinen and colleagues identify CFHR-1 as a novel inhibitor of C5 convertase and the terminal complement pathway. 1 .
Allison, Lesher, Wen-Chao, Song
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The role of complement in regulating the alloresponse
Current Opinion in Organ Transplantation, 2009This review emphasizes new information concerning the role of anaphylatoxins in the regulation of the immune response to allografts. Its timeliness relates the growing concept of the innate immune response as a regulator of the adaptive immune system and to how this concept lends itself to therapeutic advance.Recent work has extended our understanding ...
Sacks, Steven +3 more
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Complement regulators and inhibitory proteins
Nature Reviews Immunology, 2009The complement system is important for cellular integrity and tissue homeostasis. Complement activation mediates the removal of microorganisms and the clearance of modified self cells, such as apoptotic cells. Complement regulators control the spontaneously activated complement cascade and any disturbances in this delicate balance can result in damage ...
Peter F, Zipfel, Christine, Skerka
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Role of complement and complement regulators in the removal of apoptotic cells
Molecular Immunology, 2008Apoptosis, followed by rapid phagocytic clearance, is the primary mechanism by which organisms dispose of unwanted cells. The intracellular and extracellular composition of an apoptotic cell changes to decrease immunogenicity and enhance its uptake. By changing their extracellular composition, apoptotic cells acquire the capacity to bind complement ...
Trouw, L. A. +2 more
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The murine complement regulator Crry: new insights into the immunobiology of complement regulation
Cellular and Molecular Life Sciences CMLS, 2002Complement has an important role in inflammation and in the normal function of the immune system. Activated complement fragments have the capacity to bind and damage self-tissues. Cells from vertebrates express on their surface regulators of complement activation that protect them from the deleterious effects of cell-bound complement fragments ...
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Transcriptional Regulation of Complement Genes
Annual Review of Immunology, 1995Complement is a major effector system of host defense against invading pathogens. The recently completed cloning and structural characterization of almost all complement genes has allowed investigation of their regulation at the molecular level. Transcription of most complement genes is accelerated during the acute-phase response that follows tissue ...
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The Regulation of Complement on Cell Surfaces
Transfusion Medicine Reviews, 1991The regulation of complement at the surface of cells is mediated by both plasma and membrane proteins. These molecules act in concert to prevent the accelerated catabolism of complement proteins and the concomitant lysis of homologous blood cells. The deficiency of either a plasma or membrane protein predisposes to the development of disease.
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Complement Regulation During Pregnancy
Immunologic Research, 2005Complement has an important role in innate immunity and inflammation. Complement also has the capacity to attack self tissues. Cells are protected from the deleterious effects of complement. The Crry protein belongs to a family of molecules that regulates complement activation, protecting tissues from complement-mediated damage. To investigate the role
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