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Disorders of complement regulation
Drug Discovery Today: Disease Models, 2014Experiments in genetically engineered mice have elucidated the key role of the complement system in the pathogenesis of several renal disorders. This has led to the clinical evaluation of agents that inhibit complement activation in patients with complement-mediated kidney disease.
Thomas D. Barbour +2 more
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Complement escape of human pathogenic bacteria by acquisition of complement regulators
Molecular Immunology, 2006Pathogenic micro-organisms employ a broad range of strategies to survive in and to persistently infect the human host. Far from being completely understood by which highly sophisticated means invading pathogens overcome the host's destructive immune defence, there is a growing body of evidence on particular mechanisms which play a pivotal role for ...
Peter, Kraiczy, Reinhard, Würzner
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The structure of complement C3b provides insights into complement activation and regulation
Nature, 2006The human complement system is an important component of innate immunity. Complement-derived products mediate functions contributing to pathogen killing and elimination. However, inappropriate activation of the system contributes to the pathogenesis of immunological and inflammatory diseases.
A, Abdul Ajees +5 more
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Regulation of Complement Activity by Vaccinia Virus Complement-Control Protein
Journal of Infectious Diseases, 1992A major protein secreted by vaccinia virus-infected cells has structural similarity to the super-family of complement-control proteins. This vaccinia complement-control protein (VCP) was studied to determine how it regulates complement activation. VCP was bound by C4b and C3b and served as a cofactor with factor I in cleaving these two molecules.
R, McKenzie +4 more
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‘‘Homologous restriction’’ in complement lysis: roles of membrane complement regulators
Xenotransplantation, 2005Abstract: The complement system is a powerful bactericidal immune defence with the potential to damage self cells. Protection of self is provided by expression on cells of a battery of membrane regulators that inhibit activation of complement. Roles of complement in the rejection of transplanted organs have long been recognized, and are particularly ...
B Paul, Morgan +2 more
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Immune regulation of complement components in vivo
Cellular Immunology, 1982Immune regulation of individual complement components has been studied in F1 hybrids obtained from mating normal males with females homozygous for a genetically controlled deficiency of those components. Experiments have been performed with C5-deficient mice, C6-deficient rabbits, and C4-deficient guinea pigs.
J N, Goldman +3 more
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Competition as a Complement to Regulation
The Energy Journal, 1985Competition and regulation are often perceived to be in conflict, because regulation usually evolves in response to a failure of the market system. In the case of public utilities in the United States, the familiar argument is that production scale economies make it cheaper for a single firm to provide essential products or services than for two or ...
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Complement Regulation in Tears
1985Abstract As previously reported human tears contain factors which inhibit the activation of the complement system. Using a new elisa method, complement activation in human serum was measured by detecting C3, C4 and C5 deposition on solid phase coated immune complexes.
F. KIEVITS, A. KIJLSTRA
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Complement regulation in the GalT KO era
Xenotransplantation, 2010A number of institutes have reported on the successful production of alpha-galactosyltransferase knockout (GalT-KO) pigs. After producing such pigs, hyperacute rejection appeared to no longer be a problem. However, acute vascular rejection (AVR)/acute humoral xenograft rejection (AHXR) is defined as a rejection that begins within 24 h after ...
Shuji, Miyagawa +8 more
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