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Complement System in Alzheimer’s Disease [PDF]

International Journal of Molecular Sciences, 2021
Alzheimer’s disease is a type of dementia characterized by problems with short-term memory, cognition, and difficulties with activities of daily living. It is a progressive, neurodegenerative disorder. The complement system is an ancient part of the innate immune system and comprises of more than thirty serum and membrane-bound proteins.
Akash Shah, Uday Kishore, Abhishek Shastri   +2 more
openalex   +6 more sources

The complement system in lipid-mediated pathologies [PDF]

Frontiers in Immunology
The complement system, a coordinator and facilitator of the innate immune response, plays an essential role in maintaining host homeostasis. It promotes clearance of pathogen- and danger-associated molecular patterns, regulates adaptive immunity, and can
Lejla Alic, Kristina Dendinovic, Nikolina Papac-Milicevic   +2 more
doaj   +2 more sources

Congenital Human Cytomegalovirus and the Complement System [PDF]

Viruses
Congenital human cytomegalovirus (HCMV) infection is the most common vertically transmitted viral infection, and it affects 1 in 200 live births worldwide.
Andrea Canto Garon, Yujun Liu, Fenyong Liu   +2 more
doaj   +2 more sources

Targeting the Roots of Kidney Disease: Systematic Review of the Therapies Targeting the Complement System [PDF]

Medicina
Background/Objectives: The field of nephrology is increasingly embracing advanced treatments and clinical trials that focus on inhibiting specific components of the complement cascade, a key driver in complement-mediated kidney diseases.
Maja Roman, Michał Nowicki
doaj   +2 more sources

Biomarkers of the Complement System in Cancer [PDF]

Medeniyet Medical Journal
Objective: Cancer is a disease characterized by an unregulated division of abnormal cells in the body. The discovery of oncogenes and tumor suppressor genes has paved the way for the targeted use of individual biomarkers and proteins in cancer therapy ...
Elif KUBAT OKTEM
doaj   +2 more sources

COVID-19, Pre-Eclampsia, and Complement System

Frontiers in Immunology, 2021
COVID-19 is characterized by virus-induced injury leading to multi-organ failure, together with inflammatory reaction, endothelial cell (EC) injury, and prothrombotic coagulopathy with thrombotic events.
Chiara Agostinis, Alessandro Mangogna, Andrea Balduit, Azin Aghamajidi, Giuseppe Ricci, Giuseppe Ricci, Uday Kishore, Roberta Bulla   +7 more
doaj   +1 more source

Terminal Complement Pathway Deficiency in an Adult Patient with Meningococcal Sepsis

Case Reports in Immunology, 2022
The complement system is an essential part of our innate immune system. Three enzymatic activation pathways are described, all converging into a common terminal pathway which causes lysis of the target cell.
F. Staels, W. Meersseman, P. Stordeur, K. Willekens, S. Van Loo, A. Corveleyn, I. Meyts, G. Meyfroidt, R. Schrijvers   +8 more
doaj   +1 more source

The Complement System in Kidney Transplantation

Cells, 2023
Kidney transplantation is the therapy of choice for patients who suffer from end-stage renal diseases. Despite improvements in surgical techniques and immunosuppressive treatments, long-term graft survival remains a challenge.
Donata Santarsiero, Sistiana Aiello
doaj   +1 more source

The complement system [PDF]

Current Biology, 1998
Work in the authors' laboratories is supported by grants from the Arthritis and Rheumatism Council and the Wellcome Trust.
Taylor, Philip, Botto, Marina, Walport, Mark   +2 more
openaire   +2 more sources

Proprotein Convertases and the Complement System

Frontiers in Immunology, 2022
Proteins destined for secretion - after removal of the signal sequence - often undergo further proteolytic processing by proprotein convertases (PCs).
József Dobó, Andrea Kocsis, Ráhel Dani, Péter Gál   +3 more
doaj   +1 more source