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The Complement System in Kidney Transplantation [PDF]
Cells, 2023 Kidney transplantation is the therapy of choice for patients who suffer from end-stage renal diseases. Despite improvements in surgical techniques and immunosuppressive treatments, long-term graft survival remains a challenge.
Donata Santarsiero, Sistiana Aiello
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The complement system in lipid-mediated pathologies [PDF]
Frontiers in ImmunologyThe complement system, a coordinator and facilitator of the innate immune response, plays an essential role in maintaining host homeostasis. It promotes clearance of pathogen- and danger-associated molecular patterns, regulates adaptive immunity, and can
Lejla Alic +2 more
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Complement System Deficiencies in Elite Athletes [PDF]
Sports Medicine - OpenBackground Although regular physical activity improves immune competency and reduces the prevalence of inflammatory diseases, strenuous training in elite athletes is associated with an increased susceptibility to infectious complications.
Libor Vítek +3 more
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COVID-19, Pre-Eclampsia, and Complement System
Frontiers in Immunology, 2021 COVID-19 is characterized by virus-induced injury leading to multi-organ failure, together with inflammatory reaction, endothelial cell (EC) injury, and prothrombotic coagulopathy with thrombotic events.
Chiara Agostinis +7 more
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Terminal Complement Pathway Deficiency in an Adult Patient with Meningococcal Sepsis
Case Reports in Immunology, 2022 The complement system is an essential part of our innate immune system. Three enzymatic activation pathways are described, all converging into a common terminal pathway which causes lysis of the target cell.
F. Staels +8 more
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Proprotein Convertases and the Complement System
Frontiers in Immunology, 2022 Proteins destined for secretion - after removal of the signal sequence - often undergo further proteolytic processing by proprotein convertases (PCs).
József Dobó +3 more
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The Defensive Interactions of Prominent Infectious Protozoan Parasites: The Host’s Complement System
Biomolecules, 2022 The complement system exerts crucial functions both in innate immune responses and adaptive humoral immunity. This pivotal system plays a major role dealing with pathogen invasions including protozoan parasites.
Sajad Rashidi +5 more
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Antimicrobial Peptide Arenicin-1 Derivative Ar-1-(C/A) as Complement System Modulator
Marine Drugs, 2020 Antimicrobial peptides (AMPs) are not only cytotoxic towards host pathogens or cancer cells but also are able to act as immunomodulators. It was shown that some human and non-human AMPs can interact with complement proteins and thereby modulate ...
Ilia A. Krenev +11 more
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The complement system and autoimmune diseases
Chronic Diseases and Translational Medicine, 2022 The complement system plays a key role in the pathogenesis of autoimmune diseases, which usually injures the kidney. More and more studies have shown the pathogenic role and indicated that abnormal activation of the complement system was highly involved ...
Changhao Jia, Ying Tan, Minghui Zhao
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Respiratory Research, 2022 Background The efficacy and safety of complement inhibition in COVID-19 patients is unclear. Methods A multicenter randomized controlled, open-label trial.
Elisabeth De Leeuw +27 more
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