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The Complement System of Agnathans [PDF]
Frontiers in Immunology, 2018 Agnathans (lamprey and hagfish) are a group of primitive jawless fish. Jawed vertebrates possess adaptive immunity including immunoglobulins, while agnathans lack immunoglobulins but have alternative adaptive immunity in which variable lymphocyte ...
Misao Matsushita
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Complosome - the intracellular complement system. [PDF]
Nat Rev Nephrol, 2023 The complement system is a recognized pillar of host defence against infection and noxious self-derived antigens. Complement is traditionally known as a serum-effective system, whereby the liver expresses and secretes most complement components, which ...
West EE, Kemper C.
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Complement System: An Immunotherapy Target in Colorectal Cancer
Frontiers in Immunology, 2022 Colorectal cancer (CRC) is the third most common malignant tumor and the second most fatal cancer worldwide. Several parts of the immune system contribute to fighting cancer including the innate complement system.
Iman M. Talaat +7 more
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The complement system in lipid-mediated pathologies [PDF]
Frontiers in ImmunologyThe complement system, a coordinator and facilitator of the innate immune response, plays an essential role in maintaining host homeostasis. It promotes clearance of pathogen- and danger-associated molecular patterns, regulates adaptive immunity, and can
Lejla Alic +2 more
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A C3(H20) recycling pathway is a component of the intracellular complement system [PDF]
Journal of Clinical Investigation, 2017 An intracellular complement system (ICS) has recently been described in immune and nonimmune human cells. This system can be activated in a convertase-independent manner from intracellular stores of the complement component C3. The source of these stores
Michelle Elvington +4 more
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Targeting the Roots of Kidney Disease: Systematic Review of the Therapies Targeting the Complement System [PDF]
MedicinaBackground/Objectives: The field of nephrology is increasingly embracing advanced treatments and clinical trials that focus on inhibiting specific components of the complement cascade, a key driver in complement-mediated kidney diseases.
Maja Roman, Michał Nowicki
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The complement system in glioblastoma multiforme
Acta Neuropathologica Communications, 2018 The human complement system is represents the main effector arm of innate immunity and its ambivalent function in cancer has been subject of ongoing dispute.
T. A. M. Bouwens van der Vlis +6 more
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Complement System Deficiencies in Elite Athletes [PDF]
Sports Medicine - OpenBackground Although regular physical activity improves immune competency and reduces the prevalence of inflammatory diseases, strenuous training in elite athletes is associated with an increased susceptibility to infectious complications.
Libor Vítek +3 more
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The Complement System in Dialysis: A Forgotten Story?
Frontiers in Immunology, 2018 Significant advances have lead to a greater understanding of the role of the complement system within nephrology. The success of the first clinically approved complement inhibitor has created renewed appreciation of complement-targeting therapeutics ...
Felix Poppelaars +10 more
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Regulation of the Complement System by Pentraxins
Frontiers in Immunology, 2019 The functions of pentraxins, like C-reactive protein (CRP), serum amyloid protein P (SAP) and pentraxin-3 (PTX3), are to coordinate spatially and temporally targeted clearance of injured tissue components, to protect against infections and to regulate ...
Karita Haapasalo +3 more
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