Results 11 to 20 of about 24,757,633 (403)
Complement System: An Immunotherapy Target in Colorectal Cancer
Frontiers in Immunology, 2022 Colorectal cancer (CRC) is the third most common malignant tumor and the second most fatal cancer worldwide. Several parts of the immune system contribute to fighting cancer including the innate complement system.
Iman M. Talaat +7 more
doaj +2 more sources
The Complement System in the Central Nervous System: From Neurodevelopment to Neurodegeneration
Biomolecules, 2022 The functions of the complement system to both innate and adaptive immunity through opsonization, cell lysis, and inflammatory activities are well known.
Ying Chen +3 more
doaj +2 more sources
A C3(H20) recycling pathway is a component of the intracellular complement system [PDF]
Journal of Clinical Investigation, 2017 An intracellular complement system (ICS) has recently been described in immune and nonimmune human cells. This system can be activated in a convertase-independent manner from intracellular stores of the complement component C3. The source of these stores
Michelle Elvington +4 more
semanticscholar +3 more sources
The complement system in glioblastoma multiforme
Acta Neuropathologica Communications, 2018 The human complement system is represents the main effector arm of innate immunity and its ambivalent function in cancer has been subject of ongoing dispute.
T. A. M. Bouwens van der Vlis +6 more
doaj +2 more sources
The Complement System in Dialysis: A Forgotten Story?
Frontiers in Immunology, 2018 Significant advances have lead to a greater understanding of the role of the complement system within nephrology. The success of the first clinically approved complement inhibitor has created renewed appreciation of complement-targeting therapeutics ...
Felix Poppelaars +10 more
doaj +2 more sources
Regulation of the Complement System by Pentraxins
Frontiers in Immunology, 2019 The functions of pentraxins, like C-reactive protein (CRP), serum amyloid protein P (SAP) and pentraxin-3 (PTX3), are to coordinate spatially and temporally targeted clearance of injured tissue components, to protect against infections and to regulate ...
Karita Haapasalo +3 more
doaj +2 more sources
Complosome - the intracellular complement system. [PDF]
Nat Rev Nephrol, 2023 The complement system is a recognized pillar of host defence against infection and noxious self-derived antigens. Complement is traditionally known as a serum-effective system, whereby the liver expresses and secretes most complement components, which ...
West EE, Kemper C.
europepmc +2 more sources
International Journal of Molecular Sciences, 2023 The crosstalk among the complement system, immune cells, and mediators of inflammation provides an efficient mechanism to protect the organism against infections and support the repair of damaged tissues. Alterations in this complex machinery play a role
F. Lasorsa +10 more
semanticscholar +1 more source
The complement system in age-related macular degeneration
Cellular and Molecular Life Sciences, 2021 Age-related macular degeneration (AMD) is a chronic and progressive degenerative disease of the retina, which culminates in blindness and affects mainly the elderly population.
A. Armento, M. Ueffing, Simon J. Clark
semanticscholar +1 more source
The Complement System, Aging, and Aging-Related Diseases
International Journal of Molecular Sciences, 2022 The complement system is a part of the immune system and consists of multiple complement components with biological functions such as defense against pathogens and immunomodulation.
Runzi Zheng +5 more
semanticscholar +1 more source