Results 1 to 10 of about 310,548 (243)
Plasmid-encoded toxin of Escherichia coli cleaves complement system proteins and inhibits complement-mediated lysis in vitro. [PDF]
Front Cell Infect MicrobiolPlasmid-encoded toxin (Pet) is an autotransporter protein of the serine protease autotransporters of Enterobacteriaceae (SPATE) family, important in the pathogenicity of Escherichia coli. The pet gene was initially found in the enteroaggregative E. coli (EAEC) virulence plasmid, pAA2.
Correa GB +7 more
europepmc +5 more sources
A peptide dataset for target analysis of human complement system proteins [PDF]
Data BriefThe targeted LC-MS/MS method has been widely applied for peptide quantification, offering sensibility, specificity, and reproducibility to the analysis. However, it requires the prior selection of targets, including the construction of a spectral library.
Tirado T +4 more
europepmc +5 more sources
Membrane Protein Crry Maintains Homeostasis of the Complement System [PDF]
The Journal of Immunology, 2008 AbstractComplement activation is tightly regulated to avoid excessive inflammatory and immune responses. Crry−/− is an embryonic lethal phenotype secondary to the maternal complement alternative pathway (AP) attacking a placenta deficient in this inhibitor.
Xiaobo, Wu +5 more
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Cartilage oligomeric matrix protein-induced complement activation in systemic sclerosis [PDF]
Arthritis Research & Therapy, 2013 Abstract Introduction Complexes between cartilage oligomeric matrix protein (COMP) and the complement activation product C3b have been found in the circulation of patients with rheumatoid arthritis and systemic lupus erythematosus.
Otteby, Kaisa E +5 more
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INTERACTIONS OF C-REACTIVE PROTEIN WITH THE COMPLEMENT SYSTEM [PDF]
The Journal of Experimental Medicine, 1974 Protamine sulfate was found to consume large amounts of C selectively during preincubation with sera of individuals in the "acute phase". Marked depletion of C1, C4, and C2 with minimal, if any, depletion of C3-9, was observed. The consumption was time and temperature dependent, occurring most rapidly and extensively at 37°C, 0.10 M relative salt ...
Joan Siegel +2 more
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Complement Fixation in the C-reactive Protein System
Experimental Biology and Medicine, 1954 SummaryA complement fixation method based on the reaction between CRP in human test sera and rabbit CRP antisera has been described.
L H, MUSCHEL, R J, WEATHERWAX
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Rat C‐reactive protein activates the autologous complement system
Immunology, 2003 SummaryActivation of complement is a biological function of human C‐reactive protein (hCRP), whereas rat CRP (rCRP) has been claimed to be unable to activate complement. As important biological functions of proteins are probably conserved among species, we re‐evaluated, using various ligands, the capability of rCRP to activate complement.
Niubel, Diaz Padilla +6 more
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COMPLEMENT SYSTEM PROTEIN C4 AND SUSCEPTIBILITY TO HYDRALAZINE-INDUCED SYSTEMIC LUPUS ERYTHEMATOSUS
The Lancet, 1989 21 patients with systemic lupus erythematosus induced by long-term treatment with hydralazine were investigated to see whether susceptibility to this syndrome was associated with deficiency of the classical pathway complement protein, C4. 16 of 21 (76%) patients had one or more C4 null (ie, non-productive) alleles compared with 35 of 82 normal subjects
Speirs, C +4 more
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Synovial fibroblast‐like cells synthesize seven proteins of the complement system [PDF]
Arthritis & Rheumatism, 1988 AbstractFibroblast‐like cells from synovial tissue obtained during arthroscopy in 4 young adults with recent knee trauma were biosynthetically labeled with 35S‐methionine, and protein production was quantitated by immunoprecipitation and sodium dodecyl sulfate—polyacrylamide gel electrophoresis.
Y, Katz, R C, Strunk
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The Kaposi's Sarcoma-associated Herpesvirus Complement Control Protein Mimics Human Molecular Mechanisms for Inhibition of the Complement System [PDF]
Journal of Biological Chemistry, 2004 Kaposi's sarcoma-associated human herpesvirus (KSHV) is thought to cause Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Previously, we reported that the KSHV complement control protein (KCP) encoded within the viral genome is a potent regulator of the complement system; it acts both as a cofactor for factor I and ...
Linda, Mark +6 more
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