A peptide dataset for target analysis of human complement system proteins [PDF]
Data in BriefThe targeted LC-MS/MS method has been widely applied for peptide quantification, offering sensibility, specificity, and reproducibility to the analysis. However, it requires the prior selection of targets, including the construction of a spectral library.
Thais Cristina Tirado +4 more
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Factor H Family Proteins in Complement Evasion of Microorganisms [PDF]
Frontiers in Immunology, 2017 Human-pathogenic microbes possess various means to avoid destruction by our immune system. These include interactions with the host complement system that may facilitate pathogen entry into cells and tissues, expression of molecules that defuse the ...
Mihály Józsi
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Dysregulation of complement system in neuropsychiatric disorders: A mini review [PDF]
Biomarkers in Neuropsychiatry, 2022 Complement system is one of the most important defense mechanisms of the innate immune system. In addition to their roles in immune regulation, complement proteins are also involved in neurodevelopment and adult brain plasticity. Complement dysregulation
Danny Perez Sierra +2 more
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Role of the complement system in the tumor microenvironment
Cancer Cell International, 2019 The complement system has traditionally been considered a component of innate immunity against invading pathogens and “nonself” cells. Recent studies have demonstrated the immunoregulatory functions of complement activation in the tumor microenvironment (
Ronghua Zhang +4 more
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Biomarkers of the Complement System in Cancer [PDF]
Medeniyet Medical JournalObjective: Cancer is a disease characterized by an unregulated division of abnormal cells in the body. The discovery of oncogenes and tumor suppressor genes has paved the way for the targeted use of individual biomarkers and proteins in cancer therapy ...
Elif KUBAT OKTEM
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Modic type 2 changes are fibroinflammatory changes with complement system involvement adjacent to degenerated vertebral endplates [PDF]
JOR Spine, 2023 Background Vertebral endplate signal intensity changes visualized by magnetic resonance imaging termed Modic changes (MC) are highly prevalent in low back pain patients. Interconvertibility between the three MC subtypes (MC1, MC2, MC3) suggests different
Irina Heggli +15 more
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Plasmid-encoded toxin of Escherichia coli cleaves complement system proteins and inhibits complement-mediated lysis in vitro [PDF]
Frontiers in Cellular and Infection MicrobiologyPlasmid-encoded toxin (Pet) is an autotransporter protein of the serine protease autotransporters of Enterobacteriaceae (SPATE) family, important in the pathogenicity of Escherichia coli. The pet gene was initially found in the enteroaggregative E. coli (
Gabriel B. Correa +7 more
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The Complement System: A Prey of Trypanosoma cruzi
Frontiers in Microbiology, 2017 Trypanosoma cruzi is a protozoan parasite known to cause Chagas disease (CD), a neglected sickness that affects around 6–8 million people worldwide. Originally, CD was mainly found in Latin America but more recently, it has been spread to countries in ...
Kárita C. F. Lidani +3 more
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Low serum complement level is associated with higher mortality in tuberculous meningitis: a retrospective cohort study [PDF]
Encephalitis, 2023 Purpose We evaluated the associations between serum complement levels and tuberculous meningitis (TBM), bacterial meningitis (BM), and viral meningitis (VM), as well as the association between serum complement levels and mortality in TBM.
Hansol Im +7 more
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Comprehensive review of membranoproliferative glomerulonephritis: spotlighting the latest advances in revised classification and treatment [PDF]
Childhood Kidney Diseases, 2023 Membranoproliferative glomerulonephritis (MPGN) is a complex group of renal diseases characterized by a specific pattern of glomerular injury that includes thickening of the capillary wall and mesangial expansion, leading to a heterogeneous group of ...
Jeong Yeon Kim
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