Complexin in ivermectin resistance in body lice. [PDF]
PLoS Genetics, 2018 Ivermectin has emerged as very promising pediculicide, particularly in cases of resistance to commonly used pediculicides. Recently, however, the first field-evolved ivermectin-resistance in lice was reported.
Nadia Amanzougaghene +9 more
doaj +5 more sources
Re-examining how complexin inhibits neurotransmitter release
eLife, 2014 Complexins play activating and inhibitory functions in neurotransmitter release. The complexin accessory helix inhibits release and was proposed to insert into SNARE complexes to prevent their full assembly.
Thorsten Trimbuch +5 more
doaj +4 more sources
Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate Complexins [PDF]
Frontiers in Molecular Neuroscience, 2017 Complexin is a critical presynaptic protein that regulates both spontaneous and calcium-triggered neurotransmitter release in all synapses. Although the SNARE-binding central helix of complexin is highly conserved and required for all known complexin ...
Rachel T. Wragg +9 more
doaj +3 more sources
Acute Complexin Knockout Abates Spontaneous and Evoked Transmitter Release [PDF]
Cell Reports, 2019 Summary: SNARE-mediated synaptic vesicle (SV) fusion is controlled by multiple regulatory proteins that determine neurotransmitter release efficiency.
Francisco José López-Murcia +4 more
doaj +6 more sources
The interplay between synaptic integrity and age at menopause on Alzheimer's disease risk in women [PDF]
Alzheimers DementAbstract Background Early menopause increases Alzheimer's disease (AD) risk in women. Synaptic dysfunction incites and exacerbates AD progression. We investigated whether synergism between age at menopause and synaptic integrity influence AD neuropathology and cognitive trajectories in women.
Alexander M +6 more
europepmc +2 more sources
Exploring Synaptic Vesicle Glycoprotein 2A (SV2A) Alterations in Alzheimer's Disease Using Targeted Mass Spectrometry [PDF]
Alzheimers DementAbstract Background SV2A levels are decreased in Alzheimer's disease (AD) brains, as revealed by Positron Emission Tomography (PET). Whether this decrease is due to synapse loss or SV2A protein loss remains unclear, hindering treatment development and interpretation of SV2A PET as a biomarker for neurodegenerative diseases. To address this, we examined
Zetterberg H.
europepmc +2 more sources
Complexins: small but capable [PDF]
Cellular and Molecular Life Sciences, 2015 Despite intensive research, it is still unclear how an immediate and profound acceleration of exocytosis is triggered by appropriate Ca(2+)-stimuli in presynaptic terminals. This is due to the fact that the molecular mechanisms of "docking" and "priming" reactions, which set up secretory vesicles to fuse at millisecond time scale, are extremely hard to
Mohrmann, Ralf +2 more
openaire +2 more sources
Synaptic Biomarkers in Alzheimer's Dementia: A Meta‐Analysis [PDF]
Alzheimers DementAbstract Background Alzheimer's dementia (AD) is a neurodegenerative condition characterized by progressive cognitive decline. Synaptopathy—defined as loss and dysfunction of existing synapses—is a hallmark pathological feature of AD and can directly contribute to underlying cognitive deficits.
Gaur A +7 more
europepmc +2 more sources
Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release [PDF]
, 2020 Release of neurotransmitters relies on submillisecond coupling of synaptic vesicle fusion to the triggering signal: AP-evoked presynaptic Ca2+ influx.
Bello, Oscar D. +9 more
core +3 more sources
Cell Types and Synapses Expressing the SNARE Complex Regulating Proteins Complexin 1 and Complexin 2 in Mammalian Retina [PDF]
International Journal of Molecular Sciences, 2021 Complexins (Cplxs) 1 to 4 are components of the presynaptic compartment of chemical synapses where they regulate important steps in synaptic vesicle exocytosis. In the retina, all four Cplxs are present, and while we know a lot about Cplxs 3 and 4, little is known about Cplxs 1 and 2.
Uwe Thorsten Lux +8 more
openaire +2 more sources