Results 41 to 50 of about 11,073 (199)
CaMKIIalpha interacts with multi-PDZ domain protein MUPP1 in spermatozoa and prevents spontaneous acrosomal exocytosis [PDF]
, 2009 The success of acrosomal exocytosis, a complex process with a variety of inter-related steps, relies on the coordinated interaction of participating signaling molecules.
Ackermann, Frauke +5 more
core +1 more source
Aberrant function and structure of retinal ribbon synapses in the absence of complexin 3 and complexin 4 [PDF]
Journal of Cell Science, 2009 Complexins regulate the speed and Ca2+ sensitivity of SNARE-mediated synaptic vesicle fusion at conventional synapses. Two of the vertebrate complexins, Cplx3 and Cplx4, are specifically localized to retinal ribbon synapses. To test whether Cplx3 and Cplx4 contribute to the highly efficient transmitter release at ribbon synapses, we studied retina ...
Reim, K. +7 more
openaire +4 more sources
Re-visiting the trans insertion model for complexin clamping
eLife, 2015 We have previously proposed that complexin cross-links multiple pre-fusion SNARE complexes via a trans interaction to function as a clamp on SNARE-mediated neurotransmitter release.
Shyam S Krishnakumar +7 more
doaj +1 more source
Ring-like Oligomers of Synaptotagmins and Related C2 Domain Proteins [PDF]
, 2016 We recently reported that the C2AB portion of Synaptotagmin 1 (Syt1) could self-assemble into Ca2+-sensitive ring-like oligomers on membranes, which could potentially regulate neurotransmitter release.
Bello, OD +7 more
core +1 more source
Complexin: Does It Deserve Its Name? [PDF]
Neuron, 2010 Knockout and other perturbations of complexins have provided important insights and elicited controversies about their role in neurotransmitter release. New work by Yang et al. in this issue of Neuron adds important detail and complexity to existing concepts-particularly on the nature of a Ca(2+)-dependent complexin-synaptotagmin switch for the ...
openaire +4 more sources
Ein Indikator der Reifung synaptischer Vesikel [PDF]
, 1999 Titlepage, Contents 1\. Introduction 1.1 Synaptic transmission and plasticity 1.2 Proteins involved in exocytotic membrane fusion > 1.2.1 Synaptobrevin > > 1.2.2 Syntaxin > > 1.2.3 SNAP 25 1.3 Characterisation of the assembled fusion complex 1 ...
Becher, Anja
core +1 more source
Synaptic Vesicles Position Complexin to Block Spontaneous Fusion [PDF]
Neuron, 2013 Synapses continually replenish their synaptic vesicle (SV) pools while suppressing spontaneous fusion events, thus maintaining a high dynamic range in response to physiological stimuli. The presynaptic protein complexin can both promote and inhibit fusion through interactions between its α-helical domain and the SNARE complex.
Wragg, Rachel T. +7 more
openaire +2 more sources
Activity-dependence of synaptic vesicle dynamics [PDF]
, 2017 The proper function of synapses relies on efficient recycling of synaptic vesicles. The small size of synaptic boutons has hampered efforts to define the dynamical states of vesicles during recycling.
Forte, Luca A +2 more
core +2 more sources
Early motor development is abnormal in complexin 1 knockout mice
Neurobiology of Disease, 2007 Complexin I expression is dysregulated in a number of neurological diseases including schizophrenia and depression. Adult complexin 1 knockout (Cplx1−/−) mice are severely ataxic and show deficits in exploration and emotional reactivity.
Dervila Glynn +2 more
doaj +1 more source
Evolutionary conservation of complexins: from choanoflagellates to mice [PDF]
EMBO reports, 2015 Complexins are synaptic SNARE complex-binding proteins that cooperate with synaptotagmins in activating Ca(2+)-stimulated, synaptotagmin-dependent synaptic vesicle exocytosis and in clamping spontaneous, synaptotagmin-independent synaptic vesicle exocytosis. Here, we show that complexin sequences are conserved in some non-metazoan unicellular organisms
Xiaofei, Yang +5 more
openaire +2 more sources