Results 71 to 80 of about 11,073 (199)
Frontiers in Molecular Neuroscience, 2023 Nerve terminals release neuronal transmitters at morphological specializations known as active zones (AZs). Synaptic vesicle fusion at individual AZs is probabilistic, and this property is fundamental for the neuronal information transfer. Until recently,
Maria Bykhovskaia
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Epigenetic regulation of Mash1 expression [PDF]
, 2010 Mash1 is a proneural gene important for specifying the neural fate. The Mash1 locus undergoes specific epigenetic changes in ES cells following neural induction.
Beretta, Chiara, Beretta, Chiara
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NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin
eLife, 2018 SNARE complex disassembly by the ATPase NSF is essential for neurotransmitter release and other membrane trafficking processes. We developed a single-molecule FRET assay to monitor repeated rounds of NSF-mediated disassembly and reassembly of individual ...
Ucheor B Choi +6 more
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Disentangling the rationale of deforestation to understand better the partial effectiveness of protected areas. A case study for Madagascar's eastern rainforest corridor (2001-12) [PDF]
, 2015 Madagascar's notoriously high level of biodiversity is currently threaten by deforestation. Protected Areas (hereafter “PAs”) remain until now the central instrument to protect it whilst little is known about their environmental effectiveness in the ...
Aubert, Sigrid +7 more
core
Real-time visualization of complexin during single exocytic events [PDF]
Nature Neuroscience, 2010 Understanding the fundamental role of soluble NSF attachment protein receptor (SNARE) complexes in membrane fusion requires knowledge of the spatiotemporal dynamics of their assembly. We visualized complexin (cplx), a cytosolic protein that binds assembled SNARE complexes, during single exocytic events in live cells. We found that cplx appeared briefly
An, Seong J. +2 more
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Stabilization of the SNARE Core by Complexin-1 Facilitates Fusion Pore Expansion
Frontiers in Molecular Biosciences, 2021 In the neuron, neurotransmitter release is an essential function that must be both consistent and tightly regulated. The continuity of neurotransmitter release is dependent in large part on vesicle recycling. However, the protein factors that dictate the
Josh Pierson, Yeon-Kyun Shin
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Transmission, Development, and Plasticity of Synapses [PDF]
, 2015 Chemical synapses are sites of contact and information transfer between a neuron and its partner cell. Each synapse is a specialized junction, where the presynaptic cell assembles machinery for the release of neurotransmitter, and the postsynaptic cell ...
Harris, Kathryn, Littleton, J. Troy
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Hippocampal Complexin Proteins and Cognitive Dysfunction in Schizophrenia [PDF]
Archives of General Psychiatry, 2005 Converging neuroimaging and postmortem evidence indicates synaptic terminals are abnormal in schizophrenia. A putative molecular mechanism implicates abnormalities of proteins involved in the presynaptic secretory machinery, including the modulator proteins complexin I and complexin II.To determine the amount and distribution of complexin proteins in ...
Ken, Sawada +8 more
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Cell Reports, 2023 Summary: Neurotransmitter release requires assembly of the SNARE complex fusion machinery, with multiple SNARE-binding proteins regulating when and where synaptic vesicle fusion occurs.
Elizabeth A. Brija +3 more
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