Results 71 to 80 of about 2,943 (163)
Strategies for the Development of Conotoxins as New Therapeutic Leads
Marine Drugs, 2013 Peptide toxins typically bind to their target ion channels or receptors with high potency and selectivity, making them attractive leads for therapeutic development. In some cases the native peptide as it is found in the venom from which it originates can
Jonathan B. Baell +2 more
doaj +1 more source
Wearable Sensors Fabricated by 3D‐Printed Composite Hydrogel with 2D Fillers
Small Methods, Volume 10, Issue 4, 23 February 2026.This review explores how 3D printing integrates 2D conductive fillers into hydrogel matrices to fabricate high‐performance flexible sensors. By tailoring microstructures and nanomaterial interactions, these devices achieve enhanced sensitivity, durability, and environmental adaptability for healthcare monitoring, human‐machine interfaces, and robotic ...
Yaxuan Li +5 more
wiley +1 more source
Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery
Toxins, 2017 Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than 700 species, have always been one of the focuses for new drug discovery.
Bingmiao Gao +5 more
doaj +1 more source
Small Structures, Volume 7, Issue 2, February 2026.Biological models in nature reveal remarkable friction‐adhesion mechanisms, driven by intermolecular forces and suction. Researchers leverage these principles to design advanced materials with enhanced adhesion properties. By optimizing these materials under stimuli like light and electricity, new solutions emerge for regulating interface interactions ...
Yunfang Sun +9 more
wiley +1 more source
Journal of Venomous Animals and Toxins including Tropical Diseases, 2014 Background:Calcium channel blockers such as conotoxins have shown a great potential to reduce brain and spinal cord injury. MVIIC neuroprotective effects analyzed in in vitromodels of brain and spinal cord ischemia suggest a potential role of this toxin ...
Karen M Oliveira +11 more
doaj +1 more source
Cone snail genome sheds light on venom evolution
, 2021 <strong> This week in <em> GigaScience </em> we published the genome of the mediterranean cone snail, <em> Lautoconus ventricosus </em> . Cone snails produce a wide variety of powerful toxins and the new chromosome-scale genome assembly opens the door for detailed investigations of their diversity and evolution.
openaire +1 more source
Discovery Methodology of Novel Conotoxins from Conus Species
Marine Drugs, 2018 Cone snail venoms provide an ideal resource for neuropharmacological tools and drug candidates discovery, which have become a research hotspot in neuroscience and new drug development. More than 1,000,000 natural peptides are produced by cone snails, but
Ying Fu +5 more
doaj +1 more source
Bioactive Mimetics of Conotoxins and other Venom Peptides
Toxins, 2015 Ziconotide (Prialt®), a synthetic version of the peptide ω-conotoxin MVIIA found in the venom of a fish-hunting marine cone snail Conus magnus, is one of very few drugs effective in the treatment of intractable chronic pain. However, its intrathecal mode
Peter J. Duggan, Kellie L. Tuck
doaj +1 more source
In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds
Journal of Venomous Animals and Toxins including Tropical Diseases, 2016 During evolution, nature has embraced different strategies for species to survive. One strategy, applied by predators as diverse as snakes, scorpions, sea anemones and cone snails, is using venom to immobilize or kill a prey.
Eline K. M. Lebbe, Jan Tytgat
doaj +1 more source
Scientific Reports, 2018 Cone snail venoms have separately evolved for predation and defense. Despite remarkable inter- and intra-species variability, defined sets of synergistic venom peptides (cabals) are considered essential for prey capture by cone snails.
S. W. A. Himaya +2 more
doaj +1 more source