Results 61 to 70 of about 2,235 (121)

Discovery of Novel Conotoxin Candidates Using Machine Learning

Toxins, 2018
Cone snails (genus Conus) are venomous marine snails that inject prey with a lethal cocktail of conotoxins, small, secreted, and cysteine-rich peptides.
Qing Li, Maren Watkins, Samuel D. Robinson, Helena Safavi-Hemami, Mark Yandell   +4 more
doaj   +1 more source

Cell Mechanics in Cancer: Integrating Mechanotransduction Pathways Within the Tumor Microenvironment

Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.
ABSTRACT Single‐cell mechanical properties such as stiffness, elasticity, and viscosity, are crucial in governing biological processes like migration, proliferation, and differentiation. In cancer, the mechanical properties of cells undergo significant alterations, which contribute to tumor growth, metastasis, and resistance to therapy.
Merve Sevgi, Yağmur Işık, Caner Karaca, Esmahan Çağlar, Hasan Berkay Abdioğlu, Ferican Zendel, Yasemin Başbınar, Hüseyin Üvet   +7 more
wiley   +1 more source

Comparing non‐staining methods with Mutvei's solution to visualize growth increments in short‐lived intertidal marine gastropod shells

Limnology and Oceanography: Methods, Volume 24, Issue 5, May 2026.
Abstract Mutvei's solution is a widely utilized standard staining method for revealing growth increments in biogenic carbonates; however, it is a slightly toxic, destructive approach with varying success across species groups. Therefore, there has been growing interest in finding non‐toxic, less destructive, and straightforward alternative techniques ...
Mahsa Alidoostsalimi, Amy L. Prendergast, Sean Ulm, Ariana B. J. Lambrides, Ian J. McNiven, Russell N. Drysdale, Nguurruumungu Indigenous Corporation, Walmbaar Aboriginal Corporation RNTBC   +7 more
wiley   +1 more source

Olive Waste as Feed Supplement: Morphometrical Effects on the Ansa spiralis coli in Lambs

Anatomia, Histologia, Embryologia, Volume 55, Issue 3, May 2026.
ABSTRACT Feedlot systems for small ruminants require nutritionally adequate and viable diets, and the incorporation of olive residues can offer a sustainable and economically advantageous alternative. This study evaluated the effects of including olive waste at 7.5%, 15%, 22.5% and 30% in the diets of Texel × Ile‐de‐France lambs, assessing the ...
Gabriel Soares Tosatto Pellenz, Gabriel Navarrina Soares, Marcelo José Böck, Vitor Pires Pereira, William Soares Teixeira, Sérgio Carvalho, Sokol Duro, William Pérez, Luciano de Morais‐Pinto   +8 more
wiley   +1 more source

δ‐Conotoxin Structure Prediction and Analysis through Large‐Scale Comparative and Deep Learning Modeling Approaches

Advanced Science
The δ‐conotoxins, a class of peptides produced in the venom of cone snails, are of interest due to their ability to inhibit the inactivation of voltage‐gated sodium channels causing paralysis and other neurological responses, but difficulties in their ...
Stephen McCarthy, Shane Gonen
doaj   +1 more source

Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1

British Journal of Pharmacology, Volume 183, Issue 9, Page 1845-1859, May 2026.
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim, Junhyuk Woo, Sungmin Pak, Joonho Paik, Gyu‐Sang Hong, Ji Hun Wi, Sanghee Lee, Cristina Fenollar‐Ferrer, Kyungreem Han, Young Kee Shin, Uhtaek Oh   +10 more
wiley   +1 more source

Morphotypes of cone snails (Conus mustelinus), Conidae: a phenetic analysis [PDF]

Computational Ecology and Software, 2018
This study describes phenotypic differentiation of Conus mustelinus, a gastropod species belonging to Family Conidae through phenetic analysis. There exist a number of morphotypes for this species.
S. R. M. Tabugo, S.R. Boco, S.I.G Masangcay, et al.   +2 more
doaj  

Toxinology of Marine Venomous Snails

Iranian South Medical Journal, 2021
A surprisingly large number of sea snail species are venomous. Cone snail venoms are produced in a lengthy tubular duct from a complex venom gland and form a cocktail of many toxins, particularly conotoxins which have high potency and specificity for ...
Gholam Hossein Mohebbi, Iraj Nabipour
doaj  

Venomous Secretions from Marine Snails of the Terebridae Family Target Acetylcholine Receptors

Toxins, 2013
Venoms from cone snails (Conidae) have been extensively studied during the last decades, but those from other members of the suborder Toxoglossa, such as of Terebridae and Turridae superfamilies attracted less interest so far. Here, we report the effects
Cora Wunder, Dietrich Mebs, Jan Tytgat, Steve Peigneur, Annette Nicke, Alexander Kurz, Christian Melaun, Yvonne Kendel, Silke Kauferstein   +8 more
doaj   +1 more source

Discovery Methodology of Novel Conotoxins from Conus Species

Marine Drugs, 2018
Cone snail venoms provide an ideal resource for neuropharmacological tools and drug candidates discovery, which have become a research hotspot in neuroscience and new drug development. More than 1,000,000 natural peptides are produced by cone snails, but
Ying Fu, Cheng Li, Shuai Dong, Yong Wu, Dongting Zhangsun, Sulan Luo   +5 more
doaj   +1 more source