Results 51 to 60 of about 225,321 (188)

Changing climates and environments within the complex Middle to Late Pleistocene fill of an overdeepened valley at Niederweningen, Switzerland

Boreas, EarlyView.
Glacially overdeepened valleys in the northern Alpine Foreland preserve Middle to Late Pleistocene sedimentary sequences that may serve as valuable archives for reconstructing past environmental changes in response to shifts in climate. This study presents a multidisciplinary analysis of two sediment cores from the overdeepened Wehntal Valley at ...
Johannes M. Miocic, Nigel Thew, Ruth Drescher‐Schneider, Hans Rudolf Graf, Marlu Kühn, Frank Preusser, Werner H. Schoch, Lucia Wick, Heinz Furrer   +8 more
wiley   +1 more source

The complete mitochondrial DNA genome of a cone snail, Conus betulinus (Neogastropoda: Conidae), from the South China sea

Mitochondrial DNA. Part B. Resources, 2021
The complete mitochondrial genome of the tubular cone snail Conus betulinus is presented in this study. The C. betulinus mitochondrial genome was 16,240 bp with 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA) genes, 2 ribosomal RNA (rRNA) genes ...
Yanling Liao, Jinxing Fu, Bingmiao Gao, Tianle Tang   +3 more
doaj   +1 more source

Holocene shoreline displacement and the impact of the Storegga tsunami on Hinnøya, northern Norway

Boreas, EarlyView.
The Holocene relative sea‐level (RSL) history of Norway's largest island, Hinnøya, has been investigated in detail, using sediment records from 25 isolation basins. The sediments were analysed for macrofossil and phytoplankton content, which served as the basis for identifying marine–lacustrine transitions, that is isolation contacts. Terrestrial plant
Anders Romundset, Kristian Vasskog, Martin Buran, Svein Olaf Dahl, Fredrik Høgaas, Mara Sternberg   +5 more
wiley   +1 more source

The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea

Marine Drugs, 2017
The marine cone snail Conus gloriamaris is an iconic species. For over two centuries, its shell was one of the most prized and valuable natural history objects in the world.
Samuel D. Robinson, Qing Li, Aiping Lu, Pradip K. Bandyopadhyay, Mark Yandell, Baldomero M. Olivera, Helena Safavi-Hemami   +6 more
doaj   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Schistosomes and snails: A molecular encounter [PDF]

, 2014
Copyright © 2014 Knight, Arican-Goktas, Ittiprasert, Odoemelam, Miller and Bridger. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Knight, M, Arican-Goktas, Halime D., Ittiprasert, Wannaporn, Bridger, JM, Ittiprasert, W, Odoemelam, Edwin C., Odoemelam, EC, Halime eArican-Goktas, Miller, AN, Joanna eBridger, Miller, Andre N., Matty eKnight, Bridger, Joanna M., Arican-Goktas, HD, Edwin eOdeomelam, Knight, Matty, Wannaporn eIttiprasert   +16 more
core   +1 more source

Conotoxins: Therapeutic Potential and Application

Marine Drugs, 2006
The pharmacological variety of conotoxins, diverse peptides found in the venoms of marine cone snails, is well recognized. Venoms from each of the estimated 500 species of cone snails contain 50 to 200 distinct biologically active peptides.
Richard T. Layer, J. Michael McIntosh
doaj   +1 more source

Selective modulation of NaV channel gating counteracts aberrant hyperexcitability and rescues motor function and survival in a model of spinal muscular atrophy

British Journal of Pharmacology, EarlyView.
Background and Purpose Spinal muscular atrophy (SMA) is a motor neuron disease caused by SMN1 gene loss, leading to reduced survival motor neuron (SMN) protein and progressive motor neuron degeneration. Although SMN‐restoring therapies improve outcomes, residual disease burden and non‐curative efficacy underscore the need for complementary treatments ...
Fernanda C. Cardoso, Jessica A. I. Muller, Yougang Zhang, Jean Giacomotto   +3 more
wiley   +1 more source

The E‐cadherin‐Wnt‐mir‐994 Axis Repurposes a Cadherin Switch for Niche Robustness and Germline Stem Cell Maintenance

Cell Proliferation, EarlyView.
In the Drosophila ovarian niche, an E‐cadherin‐to‐N‐cadherin switch, mediated by Wnt‐mir‐994 signalling, is repurposed to ensure niche resilience. This compensatory mechanism maintains niche integrity and stem cell support upon E‐cadherin loss, revealing a robustness circuit.
Renjun Tu, Hiu Laam Yau, Runzhi Deng, Sarah E. Webb, Shiyuan Chen, Jianquan Ni, Ting Xie   +6 more
wiley   +1 more source

Transcriptomic-Proteomic Correlation in the Predation-Evoked Venom of the Cone Snail, Conus imperialis

Marine Drugs, 2019
Individual variation in animal venom has been linked to geographical location, feeding habit, season, size, and gender. Uniquely, cone snails possess the remarkable ability to change venom composition in response to predatory or defensive stimuli.
Ai-Hua Jin, Sébastien Dutertre, Mriga Dutt, Vincent Lavergne, Alun Jones, Richard J. Lewis, Paul F. Alewood   +6 more
doaj   +1 more source