Results 91 to 100 of about 5,562,313 (185)

Advances in Cytosolic dsRNA Sensing of Viral Infections

Immunology &Cell Biology, EarlyView.
Activation of cytosolic dsRNA sensors by viral infection generates multiple outcomes. dsRNA generated during viral infection, either of viral origin or from endogenous sources, can activate multiple cytosolic dsRNA sensors. Activation of PKR critically induces protein translation shutdown via phosphorylation of eukaryotic translation initiation factor ...
Sofia Maceratessi, Natalia G. Sampaio
wiley   +1 more source

Significance of connexion genes in non-syndromic deafness in Africans [PDF]

, 2013
Includes abstract.
Bosch, Jason
core   +1 more source

Dietary effects of black soldier fly oil, soybean oil, and tallow on performance, egg traits, hormones, and oviductal connexins in laying hens

Animal
The increasing demand for sustainable and energy-dense feed in poultry nutrition has prompted the exploration of alternative dietary fat sources. The objective of this study was to evaluate how three fat sources, including black soldier fly oil (BSFO ...
H. Tajudeen, A. Hosseindoust, J.Y. Mun, S.H. Ha, J.S. Kim   +4 more
doaj   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Influence of Connexin 43 Gene Knockout on the Analgesic Effect of Acupuncture in Visceral Pain Mice

针刺研究, 2008
Objective To explore the possible central and peripheral mechanisms of connexin 43 gene knockout in acupuncture analgesia.Methods Fifty-four wide type(WT) mice and 54 connexin 43 gene knockout(heterozygote,HT) mice were randomly divided into WT control ...
YU Wei-chang, HUANG Guang-ying, ZHANG Ming-min, WANG Wei1   +3 more
doaj   +2 more sources

A new approach to an old disease: Ageing, arrhythmogenic substrate and the role of risk‐factor modification in atrial fibrillation

Experimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) prevalence rises sharply with age due to two independent mechanisms. Ageing produces irreversible arrhythmogenic substrate changes through progressive fibrosis, cellular senescence and mitochondrial dysfunction, while modifiable risk factors such as obesity, hypertension, sleep apnoea, diabetes and alcohol use promote ...
Udit Thakur, Jonathan M. Kalman
wiley   +1 more source

Targeting Cx43 and N-cadherin, which are abnormally upregulated in venous leg ulcers, influences migration, adhesion and activation of Rho GTPases. [PDF]

, 2012
Venous leg ulcers can be very hard to heal and represent a significant medical need with no effective therapeutic treatment currently ...
Thrasivoulou, C, Serena Thomas, Becker, DL, Christopher Thrasivoulou (165615), Serrano, AE, Serrano Antonio E., White Alexis, Cormie Peter, Becker David L., Thomas Serena, Cormie, P, Peter Cormie (165594), Thrasivoulou Christopher, Anthony R. J. Phillips (165633), Alexis White, Wang Chiuhui Mary, Shay O'Neill (165605), Kieran T Power, Christopher Thrasivoulou, Rebecca Hu, Shay O'Neill, David L Becker, David L. Becker (165638), Anthony R J Phillips, Kieran T. Power (165618), White, A, Alexis White (165623), O'Neill Shay, Serena, T, Antonio E. Serrano (165597), Power Kieran T., Peter Cormie, Chiuhui Mary Wang (165610), Thomas Serena (165628), Rebecca Hu (165601), Mendoza-Naranjo, A, Wang, CM, Antonio E Serrano, Hu Rebecca, Phillips Anthony R. J., Ariadna Mendoza-Naranjo (165592), Hu, R, O'Neill, S, Power, KT, Ariadna Mendoza-Naranjo, Chiuhui Mary Wang, Mendoza-Naranjo Ariadna, Phillips, AR   +47 more
core   +2 more sources

Connexin 30 Deficiency Ameliorates Disease Progression at the Early Phase in a Mouse Model of Amyotrophic Lateral Sclerosis by Suppressing Glial Inflammation. [PDF]

Int J Mol Sci, 2022
Hashimoto Y, Yamasaki R, Ko S, Matsuo E, Kobayakawa Y, Masaki K, Matsuse D, Isobe N.   +7 more
europepmc   +1 more source

TMEM16A Ca2+‐activated Cl− channel: Functional interactions with cytoskeletal and membrane‐associated proteins

The Journal of Physiology, EarlyView.
Abstract figure legend The calcium‐activated chloride (ClCa) channel TMEM16A (also known as ANO1) plays critical roles in ion transport, neurotransmission and smooth muscle contraction. Dysregulation of TMEM16A channel activity contributes to the development and progression of various diseases.
Hisao Yamamura, Rubii Kondo, Yoshiaki Suzuki, Yuji Imaizumi, Aya Yamamura   +4 more
wiley   +1 more source

Connexin hemichannel blockade improves survival of striatal GABA-ergic neurons after global cerebral ischaemia in term-equivalent fetal sheep

Scientific Reports, 2017
Basal ganglia injury at term remains a major cause of disability, such as cerebral palsy. In this study we tested the hypotheses that blockade of astrocytic connexin hemichannels with a mimetic peptide would improve survival of striatal phenotypic ...
Robert Galinsky, Joanne O. Davidson, Christopher A. Lear, Laura Bennet, Colin R. Green, Alistair J. Gunn   +5 more
doaj   +1 more source