Connexin 43 is Involved in Aldosterone-Induced Podocyte Injury
Cellular Physiology and Biochemistry, 2014 Background/Aims: Connexin43 (Cx43) belongs to a family of transmembrane proteins that build cell-to-cell channels in gap junctions, which play an essential role in intercellular communication, cell proliferation, differentiation and apoptosis. The aim of
Min Yang, Bin Wang, Min Li, Bo Jiang
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A Central Role of Connexin 43 in Hypoxic Preconditioning [PDF]
The Journal of Neuroscience, 2008 Preconditioning is an endogenous mechanism in which a nonlethal exposure increases cellular resistance to subsequent additional severe injury. Here we show that connexin 43 (Cx43) plays a key role in protection afforded by preconditioning. Cx43 null mice were insensitive to hypoxic preconditioning, whereas wild-type littermate mice exhibited a ...
Jane H-C, Lin +12 more
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Single and fractionated ionizing radiation induce alterations in endothelial connexin expression and channel function [PDF]
, 2019 Radiotherapy is an effective treatment for most tumor types. However, emerging evidence indicates an increased risk for atherosclerosis after ionizing radiation exposure, initiated by endothelial cell dysfunction. Interestingly, endothelial cells express
Aerts, An +8 more
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Antidepressants impact connexin 43 channel functions in astrocytes
Frontiers in Cellular Neuroscience, 2016 Glial cells, and in particular astrocytes, are crucial to maintain neuronal microenvironment by regulating energy metabolism, neurotransmitter uptake, gliotransmission and synaptic development.
Tiffany eJeanson +6 more
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Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration
Cells, 2021 Astrocytes are intimately involved in the response to neurodegenerative stress and have become an attractive target for the development of neuroprotective therapies. However, studies often focus on astrocytes as single-cell units.
Andrew M. Boal +4 more
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Osteoinductivity of calcium phosphate mediated by connexin 43 [PDF]
Biomaterials, 2013 Recent reports have alluded to the osteoinductive properties of calcium phosphate, yet the cellular processes behind this are not well understood. To gain insight into the molecular mechanisms of this phenomenon, we have conducted a series of in vitro and in vivo experiments using a scaffoldless three dimensional (3D) dental pulp cell (DPC) construct ...
Thottala Jayaraman +4 more
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Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease
Theranostics, 2019 Rational: Myelin loss is a characteristic feature of both ischemic white matter disease and its associated vascular dementia, and is a hallmark of chronic cerebral hypoperfusion due to carotid artery stenosis.
Minghuan Wang +11 more
semanticscholar +1 more source
Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma : a preclinical F98 glioblastoma rat model study [PDF]
, 2019 Purpose Even with an optimal treatment protocol, the median survival of glioblastoma (GB) patients is only 12-15 months. Hence, there is need for novel effective therapies that improve survival outcomes.
Bonte, Ellen +11 more
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Expression of Connexin 43 in Granular Cell Tumors of the Skin, Tongue and Esophagus
Dermatopathology, 2023 Background: Granular cell tumors (GCT) are rare neoplasms of Schwann cell origin occurring in the skin and in other organs. The etiopathogenesis of GCT is yet poorly understood.
Hermann Kneitz +3 more
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Integrin-α7 signaling regulates connexin 43, M-cadherin, and myoblast fusion.
American Journal of Physiology - Cell Physiology, 2019 Regenerative medicine treatments for severe skeletal muscle injuries are limited, resulting in persistent functional deficits. Clinical options include neglecting the wound with the expectation that fibrosis will develop or using an autologous muscle ...
M. J. McClure +4 more
semanticscholar +1 more source