Results 181 to 190 of about 11,327 (216)
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The TSG101 protein binds to connexins and is involved in connexin degradation
Experimental Cell Research, 2009Gap junctions mediate electrical and metabolic communication between cells in almost all tissues and are proposed to play important roles in cellular growth control, differentiation and embryonic development. Gap junctional communication and channel assembly were suggested to be regulated by interaction of connexins with different proteins including ...
Tanja, Auth +8 more
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Connexin-30 Deletion Analysis in Connexin-26 Heterozygotes
Genetic Testing, 2003Mutations in the Connexin-26 gene (Cx 26, GJB2) are the most common cause of hereditary nonsyndromic sensorineural hearing loss (SNHL). DNA analysis of the Cx 26 gene in deaf or hard-of-hearing individuals frequently demonstrates heterozygosity despite the fact that most mutations are known to be recessive. A 342-kb deletion in a gene adjacent to Cx 26,
Victoria A, Stevenson +2 more
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The vertebrate connexin family
Cellular and Molecular Life Sciences, 2006Connexins are chordate-specific transmembrane proteins that can form gap junctional channels between adjacent cells. With the progress in vertebrate genome sequencing, it is now possible to reconstruct the main lines in the evolution of the connexin family from fishes to mammals. Four connexin groups are only found in fishes. Otherwise, the differences
V, Cruciani, S-O, Mikalsen
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2010
Non-healing cutaneous wounds such as leg ulcers are a major cause of morbidity and mortality, especially in diabetes. Currently 67% of ulcers fail to respond to treatment after 20 weeks of care, and are a substantial time and cost burden. Recent studies suggest significant increases in skin wound healing rates occur by reduction of connexin (Cx ...
Wright, Catherine, Martin, Patricia
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Non-healing cutaneous wounds such as leg ulcers are a major cause of morbidity and mortality, especially in diabetes. Currently 67% of ulcers fail to respond to treatment after 20 weeks of care, and are a substantial time and cost burden. Recent studies suggest significant increases in skin wound healing rates occur by reduction of connexin (Cx ...
Wright, Catherine, Martin, Patricia
openaire +1 more source
Life Cycle of Connexins: Regulation of Connexin Synthesis and Degradation
2006Gap-junction-forming connexins (Cx) exhibit a complex life cycle which is regulated at various levels. First, the promoter regions and binding of transcription factors to them control the transcription of the connexin genes. Translation of Cx-mRNA seems to be enabled by internal ribosome entry site elements allowing translation even under stress ...
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The many ways astroglial connexins regulate neurotransmission and behavior
Glia, 2021, Anna Capano, David Mazaud
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Therapeutic strategies targeting connexins
Nature Reviews Drug Discovery, 2018Paul D Lampe, Dale W Laird, Laird Dale W
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