Conopeptides from Cape Verde Conus crotchii [PDF]
Marine Drugs, 2013 Marine Cone snails of the genus Conus contain complex peptide toxins in their venom. Living in tropical habitats, they usually use the powerful venom for self-defense and prey capture.
Agostinho Antunes +4 more
doaj +6 more sources
Diversity and Novelty of Venom Peptides in Vermivorous Cone Snails, Subgenus <i>Rhizoconus</i> (Gastropoda: Mollusca). [PDF]
Mar DrugsA large majority of cone snails (a species in the genus Conus) are vermivorous (worm-hunting), but the diversity and bioactivity of their venom peptides remain largely unexplored.
Florece CMC +3 more
europepmc +5 more sources
Usage of Cell-Free Protein Synthesis in Post-Translational Modification of μ-Conopeptide PIIIA. [PDF]
Mar Drugs, 2023 The post-translational modifications of conopeptides are the most complicated modifications to date and are well-known and closely related to the activity of conopeptides.
Liu Y +5 more
europepmc +2 more sources
Bibliometric Review of the Literature on Cone Snail Peptide Toxins from 2000 to 2022. [PDF]
Mar Drugs, 2023 The venom of marine cone snails is mainly composed of peptide toxins called conopeptides, among which conotoxins represent those that are disulfide-rich.
Nguyen LTT, Craik DJ, Kaas Q.
europepmc +2 more sources
Cone snail species off the Brazilian coast and their venoms: a review and update. [PDF]
J Venom Anim Toxins Incl Trop Dis, 2023 The genus Conus includes over 900 species of marine invertebrates known as cone snails, whose venoms are among the most powerful described so far.
Fiorotti HB +3 more
europepmc +2 more sources
Proteomic analysis of Red Sea Conus taeniatus venom reveals potential biological applications. [PDF]
J Venom Anim Toxins Incl Trop Dis, 2021 Background: Diverse and unique bioactive neurotoxins known as conopeptides or conotoxins are produced by venomous marine cone snails. Currently, these small and stable molecules are of great importance as research tools and platforms for discovering new ...
Fouda MMA +4 more
europepmc +2 more sources
High-Throughput Prediction and Design of Novel Conopeptides for Biomedical Research and Development. [PDF]
Biodes Res, 2022 Cone snail venoms have been considered a valuable treasure for international scientists and businessmen, mainly due to their pharmacological applications in development of marine drugs for treatment of various human diseases.
Gao B +7 more
europepmc +2 more sources
Marine Origin Ligands of Nicotinic Receptors: Low Molecular Compounds, Peptides and Proteins for Fundamental Research and Practical Applications. [PDF]
Biomolecules, 2022 The purpose of our review is to briefly show what different compounds of marine origin, from low molecular weight ones to peptides and proteins, offer for understanding the structure and mechanism of action of nicotinic acetylcholine receptors (nAChRs ...
Kasheverov I +5 more
europepmc +2 more sources
δ-Conotoxin Structure Prediction and Analysis through Large-Scale Comparative and Deep Learning Modeling Approaches. [PDF]
Adv Sci (Weinh)δ‐Conotoxins are a diverse class of peptides that inhibit the inactivation of voltage‐gated sodium channels – proteins implicated in many human diseases – but which remain poorly characterized. Computational modeling of 18 different δ‐conotoxins using traditional and deep learning techniques uncovers structural features underlying the varying ...
McCarthy S, Gonen S.
europepmc +2 more sources
Identification of Novel Conotoxin Precursors from the Cone Snail Conus spurius by High-Throughput RNA Sequencing. [PDF]
Mar Drugs, 2021 Marine gastropods of the genus Conus, comprising more than 800 species, have the characteristic of injecting worms and other prey with venom. These conopeptide toxins, highly diverse in structure and action, are highly potent and specific for their ...
Zamora-Bustillos R +4 more
europepmc +2 more sources