Results 91 to 100 of about 1,281 (179)
A novel inhibitor of α9α10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily. [PDF]
PLoS ONE, 2013 Conotoxins (CTxs) selectively target a range of ion channels and receptors, making them widely used tools for probing nervous system function. Conotoxins have been previously grouped into superfamilies according to signal sequence and into families based
Sulan Luo +8 more
doaj +1 more source
Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods
Marine Drugs, 2018 A diverse range of predatory marine gastropods produce toxins, yet most of these molecules remain uncharacterized. Conus species have received the most attention from researchers, leading to several conopeptides reaching clinical trials. This review aims
Ashlin H. Turner +3 more
doaj +1 more source
Calcium channel modulation as a target in chronic pain control [PDF]
, 2017 Neuropathic pain remains poorly treated for large numbers of patients and little progress has been made in developing novel classes of analgesics. To redress this issue, ziconotide (PrialtTM ) was developed and approved as a first in class synthetic ...
Dickenson, AH +2 more
core +1 more source
A vasopressin/oxytocin-related conopeptide with γ-carboxyglutamate at position 8 [PDF]
Biochemical Journal, 2007 Vasopressins and oxytocins are homologous, ubiquitous and multifunctional peptides present in animals. Conopressins are vasopressin/oxytocin-related peptides that have been found in the venom of cone snails, a genus of marine predatory molluscs that envenom their prey with a complex mixture of neuroactive peptides.
Carolina, Möller, Frank, Marí
openaire +2 more sources
Marine Drugs, 2013 Conotoxins are small peptides present in the venom of cone snails. The snail uses this venom to paralyze and capture prey. The constituent conopeptides display a high level of chemical diversity and are of particular interest for scientists as tools ...
Rolf Boelens +4 more
doaj +1 more source
Marine Drugs, 2014 A novel conotoxin (conopeptide) was biochemically characterized from the crude venom of the molluscivorous marine snail, Conus bandanus (Hwass in Bruguière, 1792), collected in the south-central coast of Vietnam.
Bao Nguyen +7 more
doaj +1 more source
Stabilization of a-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization [PDF]
, 2011 a-Conotoxins are peptides isolated from the venom ducts of cone snails that target nicotinic acetylcholine receptors (nAChRs). They are valuable pharmacological tools and have potential applications for treating a range of conditions in humans, including
Adams, DJ +8 more
core
Analgesic treatment of ciguatoxin-induced cold allodynia [PDF]
, 2013 Ciguatera, the most common form of nonbacterial ichthyosarcotoxism, is caused by consumption of fish that have bioaccumulated the polyether sodium channel activator ciguatoxin.
Cabot, Peter J. +8 more
core +1 more source
Recombinant Expression and Characterization of α-Conotoxin LvIA in Escherichia coli
Marine Drugs, 2016 α-Conotoxin LvIA is derived from Conus lividus, native to Hainan, and is the most selective inhibitor of α3β2 nicotinic acetylcholine receptors (nAChRs) known to date.
Xiaopeng Zhu +6 more
doaj +1 more source
‘Messy’ Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency
Marine Drugs, 2019 Integrated venomics techniques have shown that variable processing of conotoxins from Conus marmoreus resulted in a dramatic expansion in the number of expressed conotoxins. One conotoxin from C.
Rebekah Ziegman +5 more
doaj +1 more source