Diversity of Conopeptides and Their Precursor Genes of Conus Litteratus. [PDF]
Mar Drugs, 2020 The venom of various Conus species is composed of a rich variety of unique bioactive peptides, commonly referred to as conotoxins (conopeptides). Most conopeptides have specific receptors or ion channels as physiologically relevant targets. In this paper,
Li X, Chen W, Zhangsun D, Luo S.
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Proteomic analysis of the venom of Conus flavidus from Red Sea reveals potential pharmacological applications. [PDF]
J Genet Eng BiotechnolBackground: Venomous marine cone snails produce unique neurotoxins called conopeptides or conotoxins, which are valuable for research and drug discovery.
Germoush MO +9 more
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Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human α3β4 Nicotinic Acetylcholine Receptor. [PDF]
Mar Drugs, 2022 Conopeptides are peptides in the venom of marine cone snails that are used for capturing prey or as a defense against predators. A new cysteine-poor conopeptide, Czon1107, has exhibited non-competitive inhibition with an undefined allosteric mechanism in
Ma Y +9 more
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Peptide Toxins from Marine <i>Conus</i> Snails with Activity on Potassium Channels and/or Currents. [PDF]
Toxins (Basel)Toxins from Conus snails are peptides characterized by a great structural and functional diversity. They have a high affinity for a wide range of membrane proteins such as ion channels, neurotransmitter transporters, and G protein-coupled receptors ...
Martínez-Hernández L +2 more
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The first Conus genome assembly reveals a primary genetic central dogma of conopeptides in C. betulinus. [PDF]
Cell Discov, 2021 Although there are various Conus species with publicly available transcriptome and proteome data, no genome assembly has been reported yet. Here, using Chinese tubular cone snail (C.
Peng C +24 more
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The ATP-mediated cytokine release by macrophages is down-modulated by unconventional α9* nicotinic acetylcholine receptors. [PDF]
Front ImmunolObjectiveThe clinical interest in mechanisms controlling the biosynthesis and release of the pro-inflammatory cytokine interleukin (IL)-1β is outstanding, as IL-1β is associated with life-threatening inflammatory diseases including hyperinflammation ...
Wolf PMK +16 more
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Molecular Phylogeny, Classification and Evolution of Conopeptides [PDF]
Journal of Molecular Evolution, 2018 Conopeptides are toxins expressed in the venom duct of cone snails (Conoidea, Conus). These are mostly well-structured peptides and mini-proteins with high potency and selectivity for a broad range of cellular targets.
Favreau, P. +4 more
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Biomedical Potential of the Neglected Molluscivorous and Vermivorous Conus Species. [PDF]
Mar Drugs, 2022 Within the Conidae family, the piscivorous Conus species have been a hotspot target for drug discovery. Here, we assess the relevance of Conus and their other feeding habits, and thus under distinctive evolutionary constraints, to highlight the potential
Zhao Y, Antunes A.
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Anti-Ovarian Cancer Conotoxins Identified from Conus Venom. [PDF]
Molecules, 2022 Conotoxins constitute a treasury of drug resources and have attracted widespread attention. In order to explore biological candidates from the marine cone snail, we isolated and identified three novel conopeptides named as Vi14b, Vi002, Vi003, three ...
Ju S +9 more
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Diversity of Conopeptides and Conoenzymes from the Venom Duct of the Marine Cone Snail Conus bayani as Determined from Transcriptomic and Proteomic Analyses. [PDF]
Mar Drugs, 2021 Marine cone snails are predatory gastropods characterized by a well-developed venom apparatus and highly evolved hunting strategies that utilize toxins to paralyze prey and defend against predators.
Rajaian Pushpabai R +4 more
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