In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2016 During evolution, nature has embraced different strategies for species to survive. One strategy, applied by predators as diverse as snakes, scorpions, sea anemones and cone snails, is using venom to immobilize or kill a prey.
Eline K. M. Lebbe, Jan Tytgat
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Snails In Silico: A Review of Computational Studies on the Conopeptides [PDF]
Marine Drugs, 2019 Marine cone snails are carnivorous gastropods that use peptide toxins called conopeptides both as a defense mechanism and as a means to immobilize and kill their prey.
Rachael A. Mansbach +4 more
doaj +3 more sources
Transcriptomic Analysis of Marine Gastropod Hemifusus tuba Provides Novel Insights into Conotoxin Genes [PDF]
Marine Drugs, 2019 The marine gastropod Hemifusus tuba is served as a luxury food in Asian countries and used in traditional Chinese medicine to treat lumbago and deafness. The lack of genomic data on H.
Ronghua Li +6 more
doaj +4 more sources
Conotoxin Patenting Trends in Academia and Industry. [PDF]
Mar Drugs, 2022 Sea snails of the genus Conus produce toxins that have been the subjects of numerous studies, projects, publications, and patents over the years. Since Conus toxins were discovered in the 1960s, their biological activity has been thought to have high ...
Sanchez-Campos N +2 more
europepmc +2 more sources
Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp. [PDF]
Marine Drugs, 2016 Cone snails are predatory creatures using venom as a weapon for prey capture and defense. Since this venom is neurotoxic, the venom gland is considered as an enormous collection of pharmacologically interesting compounds having a broad spectrum of ...
Eline K. M. Lebbe +9 more
doaj +3 more sources
Conotoxins as Tools to Understand the Physiological Function of Voltage-Gated Calcium (CaV) Channels [PDF]
Marine Drugs, 2017 Voltage-gated calcium (CaV) channels are widely expressed and are essential for the completion of multiple physiological processes. Close regulation of their activity by specific inhibitors and agonists become fundamental to understand their role in ...
David Ramírez +3 more
doaj +3 more sources
Predatory and Defensive Strategies in Cone Snails. [PDF]
Toxins (Basel)Cone snails are carnivorous marine animals that prey on fish (piscivorous), worms (vermivorous), or other mollusks (molluscivorous). They produce a complex venom mostly made of disulfide-rich conotoxins and conopeptides in a compartmentalized venom gland.
Ratibou Z, Inguimbert N, Dutertre S.
europepmc +2 more sources
ConoServer: updated content, knowledge, and discovery tools in the conopeptide database [PDF]
Nucleic Acids Research, 2011 International audienceConoServer (http://www.conoserver.org) is a database specializing in the sequences and structures of conopeptides, which are toxins expressed by marine cone snails. Cone snails are carnivorous gastropods, which hunt their prey using
Kaas, Quentin +4 more
core +4 more sources
Improved prediction of conopeptide superfamilies with ConoDictor 2.0. [PDF]
Bioinform Adv, 2021 Abstract Motivation Cone snails are among the richest sources of natural peptides with promising pharmacological and therapeutic applications. With the reduced costs of RNAseq, scientists now heavily rely on venom gland transcriptomes for the mining of novel bioactive conopeptides, but the ...
Koua D, Ebou A, Dutertre S.
europepmc +3 more sources
A Chemoenzymatic Approach To Produce a Cyclic Analogue of the Analgesic Drug MVIIA (Ziconotide)
Angewandte Chemie, Volume 135, Issue 29, July 17, 2023., 2023 A chemoenzymatic method has been developed to prepare backbone cyclic analogues of the ω‐conotoxin MVIIA. The most potent cyclic analogue, cM‐7, shows highly improved stability and maintains the activity of the native peptide. Abstract Ziconotide (ω‐conotoxin MVIIA) is an approved analgesic for the treatment of chronic pain.
Yan Zhou +8 more
wiley +2 more sources