Results 41 to 50 of about 1,281 (179)

Synthesis and evaluation of a novel analgesic conotoxin Lt7b that inhibits calcium currents and increases sodium currents

Journal of Cellular and Molecular Medicine, Volume 26, Issue 20, Page 5330-5334, October 2022., 2022
Abstract Conotoxins are promising neuropharmacological tools and drug candidates due to their high efficiency and specificity in targeting ion channels or neurotransmitter receptors. In this study, a novel O2‐superfamily conotoxin, Lt7b, was synthesized and its pharmacological functions were evaluated.
Yun Wu, Manyi Yang, Yubin Li, Wei Zhang, Maojun Zhou   +4 more
wiley   +1 more source

Discovery of KV1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges

Medicinal Research Reviews, Volume 41, Issue 4, Page 2423-2473, July 2021., 2021
Abstract The KV1.3 voltage‐gated potassium ion channel is involved in many physiological processes both at the plasma membrane and in the mitochondria, chiefly in the immune and nervous systems. Therapeutic targeting KV1.3 with specific peptides and small molecule inhibitors shows great potential for treating cancers and autoimmune diseases, such as ...
Špela Gubič, Louise A. Hendrickx, Žan Toplak, Maša Sterle, Steve Peigneur, Tihomir Tomašič, Luis A. Pardo, Jan Tytgat, Anamarija Zega, Lucija P. Mašič   +9 more
wiley   +1 more source

ConoDictor: a tool for prediction of conopeptide superfamilies [PDF]

Nucleic Acids Research, 2012
ConoDictor is a tool that enables fast and accurate classification of conopeptides into superfamilies based on their amino acid sequence. ConoDictor combines predictions from two complementary approaches-profile hidden Markov models and generalized profiles. Results appear in a browser as tables that can be downloaded in various formats.
Koua, Dominique, Brauer, Age, Laht, Silja, Kaplinski, Lauris, Favreau, Philippe, Remm, Maido, Lisacek, Frédérique, Stöcklin, Reto   +7 more
openaire   +2 more sources

Conus : First comprehensive conservation red list assessment of a marine gastropod mollusc genus [PDF]

, 2013
Marine molluscs represent an estimated 23% of all extant marine taxa, but research into their conservation status has so far failed to reflect this importance, with minimal inclusion on the authoritative Red List of the International Union for the ...
Carpenter, Kent E., Hawkins, Julie P., O'Leary, Bethan C., Peters, Howard, Roberts, Callum M.   +4 more
core   +6 more sources

ConoMode, a database for conopeptide binding modes

Database, 2020
Abstract ConoMode is a database for complex three-dimensional (3D) structures of conopeptides binding with their target proteins. Conopeptides, a large family of peptides from the venom of marine snails of the Conus genus, have exceptionally diverse sequences, and their high specificity to block ion channels makes them crucial as drug ...
Li, Xiao, Liu, Hao, Gao, Chunxiao, Li, Yangyang, Jia, Dongning, Yang, Yanbo, Yang, Jinbo, Wei, Zhiqiang, Jiang, Tao, Yu, Rilei   +9 more
openaire   +2 more sources

Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors [PDF]

, 2013
Venoms from cone snails (Conidae) have been extensively studied during the last decades, but those from other members of the suborder Toxoglossa, such as of Terebridae and Turridae superfamilies attracted less interest so far. Here, we report the effects
Kauferstein, Silke, Kendel, Yvonne, Kurz, Alexander, Mebs, Dietrich, Melaun, Christian, Nicke, Annette, Peigneur, Steve, Tytgat, Jan, Wunder, Cora   +8 more
core   +3 more sources

Characterization of the Conus bullatus genome and its venom-duct transcriptome

BMC Genomics, 2011
Background The venomous marine gastropods, cone snails (genus Conus), inject prey with a lethal cocktail of conopeptides, small cysteine-rich peptides, each with a high affinity for its molecular target, generally an ion channel, receptor or transporter.
Olivera Baldomero M, Bandyopadhyay Pradip K, Hu Hao, Yandell Mark   +3 more
doaj   +1 more source

Conopeptides promote itch through human itch receptor hMgprX1 [PDF]

Toxicon, 2018
Members of Mas related G-protein coupled receptors (Mrgpr) are known to mediate itch. To date, several compounds have been shown to activate these receptors, including chloroquine, a common antimalarial drug, and peptides of the RF-amide family. However, specific ligands for these receptors are still lacking and there is a need for novel compounds that
Espino, Samuel S., Robinson, Samuel D., Safavi-Hemami, Helena, Gajewiak, Joanna, Yang, Weishan, Olivera, Baldomero M., Liu, Qin   +6 more
openaire   +3 more sources

Mechanisms for Evolving Hypervariability: The Case of Conopeptides [PDF]

Molecular Biology and Evolution, 2001
Hypervariability is a prominent feature of large gene families that mediate interactions between organisms, such as venom-derived toxins or immunoglobulins. In order to study mechanisms for evolution of hypervariability, we examined an EST-generated assemblage of 170 distinct conopeptide sequences from the venoms of five species of marine Conus snails.
S G, Conticello, Y, Gilad, N, Avidan, E, Ben-Asher, Z, Levy, M, Fainzilber   +5 more
openaire   +2 more sources

Novel conopeptides of the I-superfamily occur in several clades of cone snails [PDF]

, 2004
The I-superfamily of conotoxins represents a new class of peptides in the venom of some Conus species. These toxins are characterized by four disulfide bridges and inhibit or modify ion channels of nerve cells.
Huys, I., Kauferstein, S., Kuch, U., Mebs, D., Melaun, C., Tytgat, J.   +5 more
core   +1 more source