Results 11 to 20 of about 18,612 (160)

Conotoxin Gene Superfamilies [PDF]

Marine Drugs, 2014
Conotoxins are the peptidic components of the venoms of marine cone snails (genus Conus). They are remarkably diverse in terms of structure and function. Unique potency and selectivity profiles for a range of neuronal targets have made several conotoxins
Samuel D. Robinson, Raymond S. Norton
doaj   +4 more sources

Structural and Functional Characterization of Conotoxins from Conus achatinus Targeting NMDAR

Marine Drugs, 2020
Conotoxin-Ac1 and its variant conotoxin-Ac1-O6P, were isolated from the venom duct of Conus achatinus, a fish-hunting cone snail species collected in the Sea of Hainan, China. Conotoxin-Ac1 is linear peptide that contain 15 amino acids.
Xiujie Liu, Ge Yao, Kang Wang, Yanli Liu, Xiukun Wan, Hui Jiang   +5 more
doaj   +1 more source

Molecular evolution and diversity of Conus peptide toxins, as revealed by gene structure and intron sequence analyses. [PDF]

PLoS ONE, 2013
Cone snails, which are predatory marine gastropods, produce a cocktail of venoms used for predation, defense and competition. The major venom component, conotoxin, has received significant attention because it is useful in neuroscience research, drug ...
Yun Wu, Lei Wang, Maojun Zhou, Yuwen You, Xiaoyan Zhu, Yuanyuan Qiang, Mengying Qin, Shaonan Luo, Zhenghua Ren, Anlong Xu   +9 more
doaj   +1 more source

Diversity of Conopeptides and Conoenzymes from the Venom Duct of the Marine Cone Snail Conus bayani as Determined from Transcriptomic and Proteomic Analyses

Marine Drugs, 2021
Marine cone snails are predatory gastropods characterized by a well-developed venom apparatus and highly evolved hunting strategies that utilize toxins to paralyze prey and defend against predators.
Rajesh Rajaian Pushpabai, Carlton Ranjith Wilson Alphonse, Rajasekar Mani, Deepak Arun Apte, Jayaseelan Benjamin Franklin   +4 more
doaj   +1 more source

A novel proline-rich M-superfamily conotoxin that can simultaneously affect sodium, potassium and calcium currents

Journal of Venomous Animals and Toxins including Tropical Diseases, 2021
Background Conotoxins have become a research hotspot in the neuropharmacology field for their high activity and specificity in targeting ion channels and neurotransmitter receptors.
Manyi Yang, Yubin Li, Longfei Liu, Maojun Zhou   +3 more
doaj   +1 more source

Systematic dissection of genomic features determining the vast diversity of conotoxins

BMC Genomics, 2023
Background Conus, a highly diverse species of venomous predators, has attracted significant attention in neuroscience and new drug development due to their rich collection of neuroactive peptides called conotoxins.
Jian-Wei Zheng, Yang Lu, Yu-Feng Yang, Dan Huang, Da-Wei Li, Xiang Wang, Yang Gao, Wei-Dong Yang, Yuanfang Guan, Hong-Ye Li   +9 more
doaj   +1 more source

High conopeptide diversity in Conus striatus: Revealed by integration of two transcriptome sequencing platforms

Frontiers in Marine Science, 2022
Marine cone snail venoms represent a vast library of bioactive peptides with proven potential as research tools, drug leads, and therapeutics. In this study, a transcriptome library of four different organs, namely radular sheath, venom duct, venom gland,
Yanling Liao, Chao Peng, Chao Peng, Yabing Zhu, Jinxing Fu, Zhiqiang Ruan, Qiong Shi, Qiong Shi, Bingmiao Gao   +8 more
doaj   +1 more source

Graph-Directed Approach for Downselecting Toxins for Experimental Structure Determination

Marine Drugs, 2020
Conotoxins are short, cysteine-rich peptides of great interest as novel therapeutic leads and of great concern as lethal biological agents due to their high affinity and specificity for various receptors involved in neuromuscular transmission. Currently,
Rachael A. Mansbach, Srirupa Chakraborty, Timothy Travers, S. Gnanakaran   +3 more
doaj   +1 more source

A novel ω-conotoxin Bu8 inhibiting N-type voltage-gated calcium channels displays potent analgesic activity

Acta Pharmaceutica Sinica B, 2021
ω-Conotoxins inhibit N-type voltage-gated calcium (CaV2.2) channels and exhibit efficacy in attenuating neuropathic pain but have a low therapeutic index. Here, we synthesized and characterized a novel ω-conotoxin, Bu8 from Conus bullatus, which consists
Jinqin Chen, Xinhong Liu, Shuo Yu, Jia Liu, Rongfang Chen, Yunxiao Zhang, Ling Jiang, Qiuyun Dai   +7 more
doaj   +1 more source

Structural studies of conotoxins [PDF]

IUBMB Life, 2009
AbstractConotoxins are small disulfide‐rich peptides from the venoms of marine cone snails. They target a variety of ion channels, transporters, and receptors besides the interest in their natural functions in venoms and they are of much interest as drug leads.
Daly, Norelle L., Craik, David J.
openaire   +3 more sources