Results 61 to 70 of about 18,612 (160)

Solution structure of α‐conotoxin SI [PDF]

FEBS Letters, 2000
The nuclear magnetic resonance solution structure of α‐conotoxin SI has been determined at pH 4.2. The 36 lowest energy structures show that α‐conotoxin SI exists in a single major solution conformation and is stabilized by six hydrogen bonds. Comparisons are made between the SI solution structure and the solution and crystal structures of α‐conotoxin ...
Benie, Andrew J., Whitford, David, Hargittai, Balazs, Barany, George, Janes, Robert W.   +4 more
openaire   +1 more source

The introduction of marine cone snail species from the coast of the Qeshm Island, contains conotoxin palliative pain in mice [PDF]

بوم‌شناسی آبزیان, 2019
Conotoxins are small toxic peptides that are synthesized in cone snail venom ducts. Conotoxins have analgesic effects in models animal. In this study, the analgesic effects with no toxicity of Persian Gulf cone snails, Conus coronatus, and Conus frigidus
Halimeh Rajabi, Hossein Zolgharnen, Mohammad Taghi Ronagh, Ahmad Savari, Mohammad Sharif Ranjbar   +4 more
doaj  

Ageing‐induced weakness of mouse NMJs is associated with reduced active zone density, synaptic event kinetics and presynaptic calcium entry

The Journal of Physiology, Volume 603, Issue 20, Page 6445-6465, October 15, 2025.
Abstract figure legend A summary of age‐related changes contributing to reduced neurotransmission in mouse neuromuscular junctions (NMJ). At 26 months, NMJs showed potentiation in short‐term plasticity compared to 4‐ or 30‐month‐old synapses, which is a proxy for reduced probability of release within individual AZs (dashed arrow). Compared to NMJs from
Yizhi Li, Elinor H. Case, Christopher Blanchard, Anna Monteleone, Meera Gandhi, Anousha Jaie, Yomna Badawi, Stephen D. Meriney   +7 more
wiley   +1 more source

Degradation kinetics of α‐conotoxin TxID [PDF]

FEBS Open Bio, 2019
α‐Conotoxin (CTx) TxID is a potent α3β4 nicotinic acetylcholine receptor (nAChR) antagonist that has been suggested as a potential drug candidate to treat addiction and small cell lung cancer. The function and structure of TxID have been well‐studied, but analyses of its stability have not previously been reported.
Pan Xu, Yang Xiong, Yiqiao Liu, Shurun Yu, Dongting Zhangsun, Yong Wu, Sulan Luo   +6 more
openaire   +3 more sources

The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea

Marine Drugs, 2017
The marine cone snail Conus gloriamaris is an iconic species. For over two centuries, its shell was one of the most prized and valuable natural history objects in the world.
Samuel D. Robinson, Qing Li, Aiping Lu, Pradip K. Bandyopadhyay, Mark Yandell, Baldomero M. Olivera, Helena Safavi-Hemami   +6 more
doaj   +1 more source

High-Throughput Identification and Analysis of Novel Conotoxins from Three Vermivorous Cone Snails by Transcriptome Sequencing

Marine Drugs, 2019
The venom of each Conus species consists of a diverse array of neurophysiologically active peptides, which are mostly unique to the examined species. In this study, we performed high-throughput transcriptome sequencing to extract and analyze putative ...
Ge Yao, Chao Peng, Yabing Zhu, Chongxu Fan, Hui Jiang, Jisheng Chen, Ying Cao, Qiong Shi   +7 more
doaj   +1 more source

Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule‐based mitochondrial transport disorder to morphine tolerance

British Journal of Pharmacology, Volume 182, Issue 17, Page 4058-4079, September 2025.
Abstract Background and Purpose Morphine is among the most powerful analgesic, but its long‐term use can cause tolerance. Synaptic ATP supply is critical for maintaining synaptic transmission. Microtubule‐based mitochondrial transport ensures synaptic energy supply.
Zheng Li, Jie Liu, Jie Ju, Xiaoling Peng, Wei Zhao, Jihao Ren, Xiaoqian Jia, Jihong Wang, Ye Tu, Feng Gao   +9 more
wiley   +1 more source

In Vitro Effect of the Synthetic cal14.1a Conotoxin, Derived from Conus californicus, on the Human Parasite Toxoplasma gondii

Marine Drugs, 2016
Toxins that are secreted by cone snails are small peptides that are used to treat several diseases. However, their effects on parasites with human and veterinary significance are unknown.
Marco A. De León-Nava, Eunice Romero-Núñez, Angélica Luna-Nophal, Johanna Bernáldez-Sarabia, Liliana N. Sánchez-Campos, Alexei F. Licea-Navarro, Jorge Morales-Montor, Saé Muñiz-Hernández   +7 more
doaj   +1 more source

Die Chemie und Biologie der Tetrodotoxin Naturstofffamilie

Angewandte Chemie, Volume 137, Issue 35, August 25, 2025.
Tetrodotoxin ist vor allem als das Gift des Kugelfisches bekannt, einer Delikatesse in der japanischen Küche. Seine Toxizität beruht auf der selektiven Blockade von NaV Kanälen, wie am Beispiel der NaV1.7 Pore dargestellt, wobei das DEKA Motiv hervorgehoben ist, das für die Durchlässigkeit von Natriumionen verantwortlich ist.
Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B. Konrad   +6 more
wiley   +1 more source

A Transcriptomic Survey of Ion Channel-Based Conotoxins in the Chinese Tubular Cone Snail (Conus betulinus)

Marine Drugs, 2017
Conotoxins in the venom of cone snails (Conus spp.) are a mixture of active peptides that work as blockers, agonists, antagonists, or inactivators of various ion channels.
Yu Huang, Chao Peng, Yunhai Yi, Bingmiao Gao, Qiong Shi   +4 more
doaj   +1 more source