Results 71 to 80 of about 18,612 (160)

The Chemistry and Biology of the Tetrodotoxin Natural Product Family

Angewandte Chemie International Edition, Volume 64, Issue 35, August 25, 2025.
Tetrodotoxin is best known as the poison of the pufferfish, which is a delicacy in Japanese cuisine. Its toxicity arises from the selective blockage of NaV channels, which is depicted for the NaV1.7 pore, highlighting the DEKA motif, which permeates sodium ions.
Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B. Konrad   +6 more
wiley   +1 more source

Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery

Toxins, 2017
Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than 700 species, have always been one of the focuses for new drug discovery.
Bingmiao Gao, Chao Peng, Jiaan Yang, Yunhai Yi, Junqing Zhang, Qiong Shi   +5 more
doaj   +1 more source

‘Messy’ Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency

Marine Drugs, 2019
Integrated venomics techniques have shown that variable processing of conotoxins from Conus marmoreus resulted in a dramatic expansion in the number of expressed conotoxins. One conotoxin from C.
Rebekah Ziegman, Andreas Brust, Prerna Jha, Fernanda C. Cardoso, Richard J. Lewis, Paul F. Alewood   +5 more
doaj   +1 more source

Effects of Predator-Prey Interactions on Predator Traits: Differentiation of Diets and Venoms of a Marine Snail

Toxins, 2019
Species interactions are fundamental ecological forces that can have significant impacts on the evolutionary trajectories of species. Nonetheless, the contribution of predator-prey interactions to genetic and phenotypic divergence remains largely unknown.
David A. Weese, Thomas F. Duda
doaj   +1 more source

Antimycobacterial Activity: A New Pharmacological Target for Conotoxins Found in the First Reported Conotoxin from Conasprella ximenes

Toxins, 2018
Mycobacterium tuberculosis is the etiological agent of tuberculosis, an airborne infectious disease that is a leading cause of human morbidity and mortality worldwide.
Andrea Figueroa-Montiel, Johanna Bernáldez, Samanta Jiménez, Beatrix Ueberhide, Luis Javier González, Alexei Licea-Navarro   +5 more
doaj   +1 more source

Residues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRs

Marine Drugs, 2016
Nicotinic acetylcholine receptors (nAChRs) are targets for developing new drugs to treat severe pain, nicotine addiction, Alzheimer disease, epilepsy, etc. α-Conotoxins are biologically and chemically diverse. With 12–19 residues and two disulfides, they
Bo Lin, Shihua Xiang, Mengsen Li
doaj   +1 more source

Identification of “alpha-conotoxin-like” Peptide in Conus pennaceus Born, 1778, Venom [PDF]

بوم‌شناسی آبزیان, 2018
Conic snails are slow-moving carnivorous that use a very powerful venom to hunt. This venom is a combination of different toxins from the family of conototoxins.
Hadi Dehghani, Mehdi Fazeli, Hamid Rajaeian, Saeid Hosseinzadeh, Mahboobeh Ashrafi   +4 more
doaj  

Conotoxins.

Journal of Biological Chemistry, 1991
B M, Olivera, J, Rivier, J K, Scott, D R, Hillyard, L J, Cruz   +4 more
openaire   +2 more sources

A deep learning framework (CreoPep) for target-specific design and optimization of conotoxin peptides. [PDF]

Commun Chem
Ge C, Tae HS, Lu L, Zhang Z, Huang Z, An B, Wang Y, Jiang T, Cai W, Chang S, Adams DJ, Yu R.   +11 more
europepmc   +1 more source

Gene expression, purification, and functional characterization of recombinant conotoxin μ-TIIIA and TIIIAlaMut in Escherichia coli with clinical evaluation of antiwrinkle efficacy. [PDF]

BioTechnologia (Pozn)
Mikiewicz D, Mazurkiewicz-Pisarek A, Janczewska M, De Waele J, Mazurkiewicz A, Stefanek A, Bosmans F, Lew-Mirska A, Styczeń P, Ciach T.   +9 more
europepmc   +1 more source