Results 91 to 100 of about 4,686 (201)

Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible Na_V Channel Inhibitor

Biomedicines, 2020
Voltage-gated sodium (NaV) channel subtypes, including NaV1.7, are promising targets for the treatment of neurological diseases, such as chronic pain. Cone snail-derived µ-conotoxins are small, potent NaV channel inhibitors which represent potential drug
Kirsten L. McMahon, Hue N.T. Tran, Jennifer R. Deuis, Richard J. Lewis, Irina Vetter, Christina I. Schroeder   +5 more
doaj   +1 more source

Microwave-assisted RCM for the synthesis of carbocyclic peptides [PDF]

, 2015
Microwave irradiation dramatically improves the efficiency of ring closing metathesis (RCM) reactions of resin-attached peptides and the technology is illustrated by the highly selective synthesis of dicarba analogues of α-conotoxin IMI.
Elaridi, Jomana, Jackson, W. Roy, Mujcinovic, Selma, Robinson, Andrea J., Van Lierop, Bianca J.   +4 more
core   +1 more source

DiPTH‐Cystine and PTH‐Cysteine in Disulfide Bond Analysis Using Automated Edman Degradation

Journal of Peptide Science, Volume 31, Issue 10, October 2025.
The mystery of PTH‐cysteine and diPTH‐cystine in the analysis of disulfide bonds is solved. Both derivatives were synthesized and applied to Edman sequencing. A time‐efficient combined workflow applying Edman and MS/MS sequencing for a comprehensive analysis of the complex disulfide connectivity in peptides and proteins was developed.
Toni Kühl, Yomnah Y. Elsayed, Alexander Terekhov, Diana Imhof   +3 more
wiley   +1 more source

Solution structure of α‐conotoxin SI [PDF]

FEBS Letters, 2000
The nuclear magnetic resonance solution structure of α‐conotoxin SI has been determined at pH 4.2. The 36 lowest energy structures show that α‐conotoxin SI exists in a single major solution conformation and is stabilized by six hydrogen bonds. Comparisons are made between the SI solution structure and the solution and crystal structures of α‐conotoxin ...
Benie, Andrew J., Whitford, David, Hargittai, Balazs, Barany, George, Janes, Robert W.   +4 more
openaire   +1 more source

Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails

Marine Drugs, 2018
Marine cone snails are a large family of gastropods that have evolved highly potent venoms for predation and defense. The cone snail venom has exceptional molecular diversity in neuropharmacologically active compounds, targeting a range of receptors, ion
Nikita Abraham, Richard J. Lewis
doaj   +1 more source

Beyond Conus: Phylogenetic relationships of Conidae based on complete mitochondrial genomes [PDF]

, 2017
Understanding how the extraordinary taxonomic and ecological diversity of cone snails (Caenogastropoda: Conidae) evolved requires a statistically robust phylogenetic framework, which thus far is not available. While recent molecular phylogenies have been
Puillandre, Nicolas, Uribe, Juan E., Zardoya, Rafael   +2 more
core   +2 more sources

Calcium regulation of muscle spindle mechanosensory afferent function

Experimental Physiology, Volume 110, Issue 10, Page 1457-1472, October 1, 2025.
Abstract Extracellular calcium is crucial for the normal function of muscle spindle sensory afferents. They express multiple calcium buffering proteins. Extracellular calcium is essential for recycling of synaptic‐like vesicles (SLVs) in the terminals and for the stretch‐evoked inward calcium current of the receptor potential.
Anna Simon, Richard A. Lofthouse, Philip Miti, Claudiu V. Giuraniuc, Robert W. Banks, Guy S. Bewick   +5 more
wiley   +1 more source

Ageing‐induced weakness of mouse NMJs is associated with reduced active zone density, synaptic event kinetics and presynaptic calcium entry

The Journal of Physiology, Volume 603, Issue 20, Page 6445-6465, October 15, 2025.
Abstract figure legend A summary of age‐related changes contributing to reduced neurotransmission in mouse neuromuscular junctions (NMJ). At 26 months, NMJs showed potentiation in short‐term plasticity compared to 4‐ or 30‐month‐old synapses, which is a proxy for reduced probability of release within individual AZs (dashed arrow). Compared to NMJs from
Yizhi Li, Elinor H. Case, Christopher Blanchard, Anna Monteleone, Meera Gandhi, Anousha Jaie, Yomna Badawi, Stephen D. Meriney   +7 more
wiley   +1 more source

Degradation kinetics of α‐conotoxin TxID [PDF]

FEBS Open Bio, 2019
α‐Conotoxin (CTx) TxID is a potent α3β4 nicotinic acetylcholine receptor (nAChR) antagonist that has been suggested as a potential drug candidate to treat addiction and small cell lung cancer. The function and structure of TxID have been well‐studied, but analyses of its stability have not previously been reported.
Pan Xu, Yang Xiong, Yiqiao Liu, Shurun Yu, Dongting Zhangsun, Yong Wu, Sulan Luo   +6 more
openaire   +3 more sources

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Na(v)1.6 in peripheral pain pathways [PDF]

, 2013
Cold allodynia, pain in response to cooling, occurs during or within hours of oxaliplatin infusion and is thought to arise from a direct effect of oxaliplatin on peripheral sensory neurons.
Abrahamsen, Adelsberger, Alloui, Almeida, Argyriou, Attal, Bautista, Benoit, Burgess, Caldwell, Carr, Cersosimo, Colburn, Cox, de la Pena, Descoeur, Dhaka, Ehrsson, Fischer, Frankenhaeuser, Gauchan, Graham, Grolleau, Hensel, Jong, Kagiava, Krishnan, Leo, Ling, Liu, Luo, Madrid, Maingret, Nassini, Park, Peier, Rasband, Reid, Renn, Rush, Sakurai, Schafer, Schiavon, Shields, Sittl, Sittl, Story, Takeshita, Teichert, Vetter, Vetter, Viana, Wilson, Xiao, Yu, Zamudio, Zhang, Zhao, Zimmermann, Zimmermann   +59 more
core   +1 more source