Results 51 to 60 of about 4,686 (201)

α-Conotoxins

The International Journal of Biochemistry & Cell Biology, 2000
Fil: Blanton, Michael P.
Arias, Hugo Rubén, Blanton, Michael P
openaire   +2 more sources

Residues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRs

Marine Drugs, 2016
Nicotinic acetylcholine receptors (nAChRs) are targets for developing new drugs to treat severe pain, nicotine addiction, Alzheimer disease, epilepsy, etc. α-Conotoxins are biologically and chemically diverse. With 12–19 residues and two disulfides, they
Bo Lin, Shihua Xiang, Mengsen Li
doaj   +1 more source

ω-Conotoxin GVIA mimetics that bind and inhibit neuronal Cav2.2 ion channels [PDF]

, 2012
The neuronal voltage-gated N-type calcium channel (Cav2.2) is a validated target for the treatment of neuropathic pain. A small library of anthranilamide-derived ω-Conotoxin GVIA mimetics bearing the diphenylmethylpiperazine moiety were prepared ...
Baell, Jonathan B., Duggan, Peter J., Lewis, Richard J., McArthur, Jeffrey R., Tranberg, Charlotte Elisabet, Tuck, Kellie L., Vetter, Irina, Yang, Aijun   +7 more
core   +3 more sources

Synthetic α-Conotoxin Mutants as Probes for Studying Nicotinic Acetylcholine Receptors and in the Development of Novel Drug Leads

Toxins, 2010
α-Conotoxins are peptide neurotoxins isolated from venomous marine cone snails that are potent and selective antagonists for different subtypes of nicotinic acetylcholine receptors (nAChRs).
Christopher J. Armishaw
doaj   +1 more source

Identification and Characterization of a Novel Family of Cysteine-Rich Peptides (MgCRP-I) from Mytilus galloprovincialis [PDF]

, 2015
We report the identification of a novel gene family (named MgCRP-I) encoding short secreted cysteine-rich peptides in the Mediterranean mussel Mytilus galloprovincialis.
Benincasa, Monica, Gerdol, Marco, Giulianini, Piero Giulio, Guarnaccia, Corrado, Lucaf\uf2, Marianna, Manfrin, Chiara, Moro, Gianluca De, Pallavicini, Alberto, Puillandre, Nicolas, Sava, Gianni, Torboli, Valentina, Venier, Paola, Zlatev, Ventislav   +12 more
core   +2 more sources

Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1

British Journal of Pharmacology, EarlyView.
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim, Junhyuk Woo, Sungmin Pak, Joonho Paik, Gyu‐Sang Hong, Ji Hun Wi, Sanghee Lee, Cristina Fenollar‐Ferrer, Kyungreem Han, Young Kee Shin, Uhtaek Oh   +10 more
wiley   +1 more source

Conotoxins Targeting Neuronal Voltage-Gated Sodium Channel Subtypes: Potential Analgesics?

Toxins, 2012
Voltage-gated sodium channels (VGSC) are the primary mediators of electrical signal amplification and propagation in excitable cells. VGSC subtypes are diverse, with different biophysical and pharmacological properties, and varied tissue distribution ...
Jeffrey R. McArthur, Oliver Knapp, David J. Adams   +2 more
doaj   +1 more source

Pathophysiological Responses to Conotoxin Modulation of Voltage-Gated Ion Currents

Marine Drugs, 2022
Voltage-gated ion channels are plasma membrane proteins that generate electrical signals following a change in the membrane voltage. Since they are involved in several physiological processes, their dysfunction may be responsible for a series of diseases
Elisabetta Tosti, Raffaele Boni, Alessandra Gallo   +2 more
doaj   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, EarlyView.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae. [PDF]

PLoS ONE, 2014
Animal venoms represent a vast library of bioactive peptides and proteins with proven potential, not only as research tools but also as drug leads and therapeutics.
Samuel D Robinson, Helena Safavi-Hemami, Lachlan D McIntosh, Anthony W Purcell, Raymond S Norton, Anthony T Papenfuss   +5 more
doaj   +1 more source