Results 61 to 70 of about 4,686 (201)
Structural Basis for α-Conotoxin Potency and Selectivity [PDF]
, 2009 Parkinson\u27s disease is a debilitating movement disorder characterized by altered levels of α6β2* nicotinic acetylcholine receptors (nAChRs) localized on presynaptic striatal catecholaminergic neurons.
Cornell, Kenneth A. +8 more
core +2 more sources
The Journal of Physiology, EarlyView.Abstract figure legend Left: the spontaneous quantal release of dopamine (DA) occurs at very low frequency in control conditions. Right: exogenous α‐synuclein potentiates Cav2.2 currents and DA release but drastically reduces the spontaneous firing rate of substantia nigra DA neurons.
Giulia Tomagra +12 more
wiley +1 more source
Marine Drugs, 2019 Conus ateralbus is a cone snail endemic to the west side of the island of Sal, in the Cabo Verde Archipelago off West Africa. We describe the isolation and characterization of the first bioactive peptide from the venom of this species.
Jorge L. B. Neves +10 more
doaj +1 more source
Stabilization of a-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization [PDF]
, 2011 a-Conotoxins are peptides isolated from the venom ducts of cone snails that target nicotinic acetylcholine receptors (nAChRs). They are valuable pharmacological tools and have potential applications for treating a range of conditions in humans, including
Adams, DJ +8 more
core
The synthesis and structure of an n-terminal dodecanoic acid conjugate of a-conotoxin MII [PDF]
, 2001 The alpha-conotoxin MII is a 16 amino acid long peptide toxin isolated from the marine snail, Conus magus. This toxin has been found to be a highly selective and potent inhibitor of neuronal nicotinic acetylcholine receptors of the subtype alpha3beta2 ...
Adams, D. J. +7 more
core +1 more source
Neurogastroenterology &Motility, Volume 38, Issue 3, March 2026.Mechanisms of Acetylcholine release, including typical and atypical release under neuronal blockade. Left panel illustrates the classical (quantal) cholinergic transmission and the right panel the mechanism described in the present study. High‐Affinity Choline Transporter (HCT), Acetylcholine (ACh), Acetylcholinesterase (ACE), and Tetrodotoxin (TTX ...
A. Martinez‐Daunis +4 more
wiley +1 more source
Design of New α-Conotoxins: From Computer Modeling to Synthesis of Potent Cholinergic Compounds
Marine Drugs, 2011 A series of 14 new analogs of α-conotoxin PnIA Conus pennaceus was synthesized and tested for binding to the human α7 nicotinic acetylcholine receptor (nAChR) and acetylcholine-binding proteins (AChBP) Lymnaea stagnalis and Aplysia californica.
Alexey Y. Khruschov +3 more
doaj +1 more source
Biomedicines, 2021 The FDA’s approval of peptide drugs such as Ziconotide or Exendin for pain relief and diabetes treatment, respectively, enhanced the interest to explore novel conotoxins from Conus species venom.
Pavel H. Lugo-Fabres +14 more
doaj +1 more source
Plant Biotechnology Journal, Volume 24, Issue 1, Page 31-43, January 2026.Summary In plant molecular farming, recombinant products include traditional protein targets, such as antibodies, antigens, and enzymes, but also increasingly refers to high‐value peptides, and small molecules produced by heterologous enzymatic pathways.
Maxim D. Harding, Frank Sainsbury
wiley +1 more source
Systematic dissection of genomic features determining the vast diversity of conotoxins
BMC Genomics, 2023 Background Conus, a highly diverse species of venomous predators, has attracted significant attention in neuroscience and new drug development due to their rich collection of neuroactive peptides called conotoxins.
Jian-Wei Zheng +9 more
doaj +1 more source