Results 81 to 90 of about 4,686 (201)
Functional classification of protein toxins as a basis for bioinformatic screening [PDF]
, 2017 Proteins are fundamental to life and exhibit a wide diversity of activities, some of which are toxic. Therefore, assessing whether a specific protein is safe for consumption in foods and feeds is critical.
Braun, Werner +11 more
core +3 more sources
Cancer Reports, Volume 8, Issue 11, November 2025.ABSTRACT Background The prevalence of cancer poses significant challenges to treatment, largely because of drug resistance along with other side effects. Current studies have been investigating the growth factors more than other biologic tumor features, such as neurobiologic features.
Mohammad Hossein Azadi +3 more
wiley +1 more source
Three-Dimensional Structure of Conotoxin tx3a: A m-1 Branch Peptide of the M-Superfamily [PDF]
, 2008 The M-superfamily, one of eight major conotoxin superfamilies found in the venom of the cone snail, contains a Cys framework with disulfide-linked loops labeled 1, 2, and 3 (- CC1C2C3CC-). M-superfamily conotoxins can be divided into the m-1, -2, -3 and -
McDougal, Owen M. +3 more
core +1 more source
Ecology and Evolution, Volume 15, Issue 11, November 2025.We examined patterns of dietary and genetic variation of a broadly distributed, Indo‐West Pacific cone snail at four sites in French Polynesia and compared them to populations at Guam, American Samoa, and Rapa Nui. Our results indicate that populations at French Polynesia possess broad and overlapping diets that are most similar to those of Rapa Nui ...
Thomas F. Duda Jr +1 more
wiley +1 more source
Constrained De Novo Sequencing of Conotoxins [PDF]
Journal of Proteome Research, 2012 De novo peptide sequencing by mass spectrometry (MS) can determine the amino acid sequence of an unknown peptide without reference to a protein database. MS-based de novo sequencing assumes special importance in focused studies of families of biologically active peptides and proteins, such as hormones, toxins, and antibodies, for which amino acid ...
Swapnil, Bhatia +8 more
openaire +2 more sources
Marine Drugs, 2018 α-Conotoxins from Conus snails are capable of distinguishing muscle and neuronal nicotinic acetylcholine receptors (nAChRs). α-Conotoxin RgIA and αO-conotoxin GeXIVA, blocking neuronal α9α10 nAChR, are potential analgesics ...
Elena V. Kryukova +8 more
doaj +1 more source
Molecular Phylogeny, Classification and Evolution of Conopeptides [PDF]
, 2018 Conopeptides are toxins expressed in the venom duct of cone snails (Conoidea, Conus). These are mostly well-structured peptides and mini-proteins with high potency and selectivity for a broad range of cellular targets.
Favreau, P. +4 more
core
Pharmacological Inhibition of Voltage-gated Ca2+ Channels for Chronic Pain Relief [PDF]
, 2014 Chronic pain is a major therapeutic problem as the current treatment options are unsatisfactory with low efficacy and deleterious side effects. Voltage-gated Ca2+ channels (VGCCs), which are multi-complex proteins consisting of α1, β, γ, and α2δ subunits,
Lee, Seungkyu
core +1 more source
Acta Physiologica, Volume 241, Issue 11, November 2025.ABSTRACT Aim To elucidate the molecular mechanism of cold sensing by visceral sensory endings, a side‐by‐side characterization of cold‐sensitive (CS) neurons in adult mouse trigeminal (TG) and vagal ganglia (VG) was performed. Methods A combination of physiological, pharmacological, molecular, and genetic tools was employed on trigeminal and vagal ...
Katharina Gers‐Barlag +4 more
wiley +1 more source
Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery
Toxins, 2017 Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than 700 species, have always been one of the focuses for new drug discovery.
Bingmiao Gao +5 more
doaj +1 more source