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Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis
Advanced Science, EarlyView.Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang +9 more
wiley +1 more source
Advanced Science, EarlyView.Potential‐controlled NH4+‐assisted reversible electrodeposition of molecular metal oxide clusters enables dynamic solution‐to‐solid electron storage. Leveraging this deposition/dissolution reaction chemistry, polyoxometalate‐based hybrid flow batteries are demonstrated as a new platform for deposition‐based electrochemical energy storage.
Ke Wang +3 more
wiley +1 more source
The XCL1-Mediated DNA Vaccine Targeting Type 1 Conventional Dendritic Cells Combined with Gemcitabine and Anti-PD1 Antibody Induces Potent Antitumor Immunity in a Mouse Lung Cancer Model. [PDF]
Int J Mol SciZhang K +10 more
europepmc +1 more source
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The Conventional Dendritic Cell Lineage Is Born
Nature Reviews Immunology, 2021Martin Guilliams and Charlotte Scott summarize some of the key studies that led to a refined dendritic cell nomenclature system based on ontogeny.
Martin Guilliams, Charlotte Scott
exaly +3 more sources
Merocytic dendritic cell: a new subset of conventional dendritic cells
The Journal of Immunology, 2019Abstract Conventional dendritic cells (cDC) are potent antigen-presenting cells that induce the activation of naïve T cells in response to pathogens. cDC activity is mediated primarily by two cDC subsets, namely cDC1 and cDC2, each bearing unique properties.
Cindy Audiger, Sylvie Lesage
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Isolation of Conventional Murine Lung Dendritic Cell Subsets
2022In the lungs, immune cells make contact with different antigens every day. This requires an adequate immune response. Dendritic cells (DCs) form a dense network in the respiratory mucosa and continuously sample inhaled allergens. They play an important role in bridging innate and adaptive immunity.
Elisabeth, De Leeuw +3 more
openaire +2 more sources
The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity [PDF]
Trends in Cancer, 2018 Dendritic cells (DCs) are key orchestrators of immune responses. A specific DC subset, conventional type 1 DCs (cDC1s), has been recently associated with human cancer patient survival and, in preclinical models, is critical for the spontaneous rejection of immunogenic cancers and for the success of T cell-based immunotherapies.
Caetano Reis e Sousa, Jan P Böttcher
exaly +3 more sources
Isolation of Conventional Murine Lung Dendritic Cell Subsets
Current Protocols in Immunology, 2018AbstractThe lungs are continuously exposed to environmental threats, requiring an adequate and stringent immune response of a heterogeneous set of effector cells. Dendritic cells (DCs) form a dense network in the respiratory mucosa and act as the central regulators of the different components of this response, both sensing the nature of the threats and
Cédric, Bosteels +2 more
openaire +2 more sources
Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells
Nature Immunology, 2009Little is known of how and where bacterial recognition triggers the induction of type I interferon. Whether the type of recognition receptor used in these responses is determined by the subcellular location of bacteria is not understood. Here we show that phagosomal bacteria such as group B streptococcus, but not cytosolic bacteria, potently induced ...
MANCUSO, Giuseppe +7 more
openaire +3 more sources