Results 61 to 70 of about 15,951 (206)

Calcium Binding and Transport by Coenzyme Q [PDF]

, 2011
Coenzyme Q10 (CoQ10) is one of the essential components of the mitochondrial electron-transport chain (ETC) with the primary function to transfer electrons along and protons across the inner mitochondrial membrane (IMM).
Bogeski, Ivan, Gulaboski, Rubin, Kappl, Reinhard, Mirceski, Valentin, Stefova, Marina, Petreska, Jasmina, Hoth, Markus   +6 more
core   +2 more sources

Rescuing Mitochondrial Dysfunction in Macrophages Prevents Osteonecrosis of the Jaw in Anti‐Resorptive Therapy

Advanced Science, EarlyView.
Schematic model showing the suggested mechanism that ZA induces classical activation of macrophages by impairing mitochondrial biofunction and inhibiting mitochondrial clearance to contribute to the pathological process of BRONJ. RAPA‐loaded nanoparticles ZDPR has shown potential in alleviating BRONJ lesions as well as treating osteoporosis or ...
Hang Zhang, Xin Shen, Haiyang Liu, Xinxi Yuan, Mumin Cao, Xuepeng Lv, Ziji Ling, Songsong Guo, Rongyao Xu, Xiang Li, Hongbing Jiang   +10 more
wiley   +1 more source

Coenzyme Q10 and embryonic development: a potential role in reproductive medicine

Акушерство, гинекология и репродукция
Maternal mitochondria provide energy to the embryo through oxidative phosphorylation before blastocyst implantation, where intracellular energy is mainly supplied by glycolysis.
A. U. Khamadyanova, R. M. Mannanov, D. M. Smakova, F. I. Musaeva, D. G. Bedelov, A. E. Ibragimov, A. A. Rusinova, M. M. Salikhova, S. V. Shtukaturova, T. V. Doroshenko, M. V. Fattakhova, M. K. Rakhimova, L. R. Marinova   +12 more
doaj   +1 more source

The Effect of Coenzyme Q10 on Liver Injury Induced by Valproic Acid and Its Antiepileptic Activity in Rats

Biomedicines, 2022
Valproic acid (VPA) has toxic metabolites that can elevate oxidative stress markers, and the hepatotoxicity of VPA has been reported. Coenzyme Q10 (CoQ10) is one of the most widely used antioxidants.
Fahad Alqarni, Hala S. Eweis, Ahmed Ali, Aziza Alrafiah, Mohammed Alsieni, Shahid Karim, Mosleh Ayed Alkathyri   +6 more
doaj   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia? [PDF]

, 2013
Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Both mitochondrial dysfunction and inflammation have been implicated in the pathophysiology of FM.
Alfonsi, Simona, Bullon, Pedro, Carrión, Ángel Manuel, Cordero, Mario D., Díaz-Parrado, Eduardo, Sánchez Alcázar, José Antonio   +5 more
core  

The Mitochondrial Ca(2+) Uniporter: Structure, Function, and Pharmacology. [PDF]

, 2017
Mitochondrial Ca(2+) uptake is crucial for an array of cellular functions while an imbalance can elicit cell death. In this chapter, we briefly reviewed the various modes of mitochondrial Ca(2+) uptake and our current understanding of mitochondrial Ca(2+)
A Quintana, A Raffaello, A Rasola, A Tosatto, A Varadi, AA Rowland, AI Tarasov, AN Antony, AR Marks, B Chance, B Glancy, B Moreau, C Giorgi, C Petrungaro, CC Mendes, CD Lobaton, CV Logan, CV Nicchitta, D Chaudhuri, D Chaudhuri, D De Stefani, D Jiang, D Lewis-Smith, D Tomar, D Vecellio Reane, DA Cox, DD Hall, DG Nicholls, DJ Pagliarini, E Carafoli, E Carafoli, E Kovacs-Bogdan, E Murphy, E Noack, E Rapizzi, F Fieni, F Fieni, F Perocchi, FD Vasington, G Bathori, G Beutner, G Beutner, G Csordas, G Csordas, G Csordas, G Csordas, G Csordas, G Csordas, G Csordas, G Czirjak, G Giannini, G Hajnoczky, G Hajnoczky, G Huang, G Michels, G Munch, G Szabadkai, G Szalai, G Szanda, G Szanda, GA Rutter, GC Sparagna, GD Schellenberg, GL Becker, H Vais, HF Deluca, I Bogeski, I Drago, I Zimanyi, J Matesanz-Isabel, J Nakai, J O-Uchi, J O-Uchi, J O-Uchi, J Qiu, J Santo-Domingo, J Schwartz, JD Martell, JG McCormack, JL Harrington, JM Baughman, JQ Kwong, JS Marchant, JT Lanner, JW Putney Jr, K Mallilankaraman, K Mallilankaraman, K Oxenoid, KJ Kamer, KM Holmstrom, L Buntinas, L Hymel, L Mela, L Wang, LH Jeyakumar, LK Seidlmayer, LS Jouaville, M Boerries, M Crompton, M Crompton, M Giacomello, M Giacomello, M Hoth, M Hoth, M Montero, M Montero, M Murgia, M Patron, M Plovanich, M Salvi, M Sastrasinh, MA Matlib, MF Tsai, MK Park, ML Joiner, ML Joiner, ML Litsky, ML Olson, MR Alam, MR Duchen, N MacQuaide, NE Hoffman, NJ Dolman, P Bernardi, P Koncz, P Pinton, PJ Doonan, PS Brookes, R Amann, R Jakob, R Malli, R Malli, R Perez-Campo, R Rizzuto, R Rizzuto, R Rizzuto, R Rizzuto, RM Denton, RM Denton, RM Denton, RS Sohal, S Feng, S Fuente de la, S Grimm, S Marchi, S Shanmughapriya, S Xu, SA Thayer, SS Lam, SY Ryu, T Pozzan, T Rharass, T Yamamoto, TE Gunter, TE Gunter, TE Gunter, TS Luongo, V Hung, V Paupe, VK Sharma, W Tan, WL Ying, X Pan, X Quan, Y Kirichok, Y Lee, Y Sancak, Y Wu   +167 more
core   +2 more sources

Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases

Advanced Science, EarlyView.
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh, Amir Tahavvori, Cyrus E. Kuschner, Blanca B. Espin, Jacob Kazmi, Sofhia V. Ramos, Tai Yin, Kei Hayashida, Kanako Ito‐Hagiwara, Yusuke Endo, Keitaro Yoshioka, Jun Hagiwara, Avijot Sohi, Alisha Oropallo, Ghania Haddad, Timmy Li, Lance B. Becker, Junhwan Kim   +17 more
wiley   +1 more source

Primary Coenzyme Q10 Deficiency [PDF]

, 2017
open4siCLINICAL CHARACTERISTICS: Primary coenzyme Q10 (CoQ10) deficiency is usually associated with multisystem involvement, including neurologic manifestations such as fatal neonatal encephalopathy with hypotonia; a late-onset slowly progressive ...
Doimo, Mara, Navas, P., Salviati, Leonardo, Trevisson, Eva   +3 more
core  

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source